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• W3212966732 abstract "Ocular adverse effects associated with various types of vaccine, mainly including optic neuropathy and uveitis have been widely reported for several decades.1 The commonly reported include vaccines for hepatitis B virus (HBV; 40.5%), human papillomavirus (HPV; 15.6%), and influenza virus (9.7%).2 Probable mechanisms include direct infection of the attenuated pathogen, molecular mimicry resulting hypersensitivity, and adjuvants-induced inflammation.2 Here, we present a case who developed optic disc edema in one eye and central serous chorioretinopathy (CSC) in the other eye shortly after receiving COVID-19 vaccine. A 41-year-old Asian female without systemic disease presented to our hospital with foggy vision in the right eye and inferior visual field defect in the left eye after receiving her first COVID-19 vaccine (Vaxzevria, AstraZeneca) 2 days previous. The vision on presentation was 20/20 oculus dexter (OD) and 20/30 oculus sinister (OS). Intraocular pressure was normal and the pupillary light reflex was equally reactive in both eyes. Anterior segment examination was unremarkable in both eyes. Dilated fundus examination revealed disc edema (OD) (Figure 1A) and a dome-shape serous detachment over the upper arcade (OS) (Figure 1B). Fluorescein angiography showed disc edema with dye leakage (OD; Figure 1C) and a single point of hyperfluorescence with focal area of retinal pigment epithelium (RPE) decompensation over the temporal superior vessel arcade (OS; Figure 1D). Brain imaging revealed no optic nerve inflammation or compression. She denied using any medications currently. Review of systems and laboratory studies including inflammatory and infectious markers reported unremarkable findings. Under the impression of idiopathic optic disc edema (OD) and CSC (OS), she was under regular follow-up at the clinic without invasive treatment. During follow-up, disc edema (OD) and serous retinal detachment (OS) gradually resolved spontaneously. At the visit of six-week follow-up, the disc edema (OD) and the serous detachment (OS) were both reduced (Figure 1E,F) with best corrected visual acuity (BCVA) restored to 20/20 (OD) and 20/25 (OS). At the visit of three-month follow-up, there were no disc edema (OD; Figure 1G) or serous detachment (OS; Figure 1H). BCVA was 20/20 in both eyes and the patient had no ocular symptoms remaining. Various types of vaccine against COVID-19 with different mechanisms are now available. Of these, viral vector vaccine against COVID-19 from AstraZeneca recently confirmed that it may induce inflammatory disease, such as immune thrombotic thrombocytopenia.3 We present a case of disc edema in the right eye and CSC in the left eye shortly after the first dose of AstraZeneca COVID-19 vaccine. To the best of our knowledge, this is the first case report of different intraocular complications associated with COVID-19 vaccine that simultaneously occurred in both eyes. From literature review, Benedikt et al. reported a case with bilateral acute macular neuroretinopathy 3 days after first COVID-19 vaccine (Vaxzevria, AstraZeneca]).4 Mallika et al. also reported a case of bilateral multifocal choroiditis following COVID-19 vaccination in India.5 With the increasing coverage rate of COVID-19 vaccine, ophthalmologists should consider various inflammatory ocular problems which may be an adverse effect following COVID-19 vaccination. All authors declare no conflict of interest." @default.
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• W3212966732 date "2021-11-16" @default.
• W3212966732 modified "2023-10-17" @default.
• W3212966732 title "Disc edema in one eye and central serous chorioretinopathy in the other eye shortly after <scp>AstraZeneca COVID</scp> ‐19 vaccination" @default.
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• W3212966732 doi "https://doi.org/10.1002/kjm2.12473" @default.
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