Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212967504> ?p ?o ?g. }
- W3212967504 abstract "Mosquito-borne flaviviruses, such as dengue (DENV), Zika (ZIKV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses, threaten a large part of the human populations. In absence of therapeutics and effective vaccines against each flaviviruses, targeting viral metabolic requirements in mosquitoes may hold the key to new intervention strategies. Development of metabolomics in the last decade opened a new field of research: mosquito metabolomics. It is now clear that flaviviruses rely on mosquito lipids, especially phospholipids, for their cellular cycle and propagation. Here, we review the biosyntheses of, biochemical properties of and flaviviral interactions with mosquito phospholipids. Phospholipids are structural lipids with a polar headgroup and apolar acyl chains, enabling the formation of lipid bilayer that form plasma- and endomembranes. Phospholipids are mostly synthesized through the de novo pathway and remodeling cycle. Variations in headgroup and acyl chains influence phospholipid physicochemical properties and consequently the membrane behavior. Flaviviruses interact with cellular membranes at every step of their cellular cycle. Recent evidence demonstrates that flaviviruses reconfigure the phospholipidome in mosquitoes by regulating phospholipid syntheses to increase virus multiplication. Identifying the phospholipids involved and understanding how flaviviruses regulate these in mosquitoes is required to design new interventions." @default.
- W3212967504 created "2021-11-22" @default.
- W3212967504 creator A5007864114 @default.
- W3212967504 creator A5027202045 @default.
- W3212967504 creator A5053677600 @default.
- W3212967504 creator A5090272472 @default.
- W3212967504 date "2021-11-05" @default.
- W3212967504 modified "2023-10-18" @default.
- W3212967504 title "Lipid Interactions Between Flaviviruses and Mosquito Vectors" @default.
- W3212967504 cites W12246812 @default.
- W3212967504 cites W1523414017 @default.
- W3212967504 cites W1544573343 @default.
- W3212967504 cites W1606980308 @default.
- W3212967504 cites W1669771493 @default.
- W3212967504 cites W1931440368 @default.
- W3212967504 cites W1966544875 @default.
- W3212967504 cites W1967534988 @default.
- W3212967504 cites W1967569258 @default.
- W3212967504 cites W1967629384 @default.
- W3212967504 cites W1969622294 @default.
- W3212967504 cites W1969968028 @default.
- W3212967504 cites W1977222014 @default.
- W3212967504 cites W1979039733 @default.
- W3212967504 cites W1980154361 @default.
- W3212967504 cites W1981926613 @default.
- W3212967504 cites W1981955271 @default.
- W3212967504 cites W1984167528 @default.
- W3212967504 cites W1984662248 @default.
- W3212967504 cites W1984747072 @default.
- W3212967504 cites W1986477156 @default.
- W3212967504 cites W1990981363 @default.
- W3212967504 cites W1995456171 @default.
- W3212967504 cites W1998275580 @default.
- W3212967504 cites W2003347868 @default.
- W3212967504 cites W2003564623 @default.
- W3212967504 cites W2004936696 @default.
- W3212967504 cites W2006096971 @default.
- W3212967504 cites W2010207445 @default.
- W3212967504 cites W2019725062 @default.
- W3212967504 cites W2021178815 @default.
- W3212967504 cites W2021882008 @default.
- W3212967504 cites W2023422813 @default.
- W3212967504 cites W2024970900 @default.
- W3212967504 cites W2027972205 @default.
- W3212967504 cites W2029052029 @default.
- W3212967504 cites W2037869686 @default.
- W3212967504 cites W2040562690 @default.
- W3212967504 cites W2044073767 @default.
- W3212967504 cites W2045155470 @default.
- W3212967504 cites W2045439832 @default.
- W3212967504 cites W2046189032 @default.
- W3212967504 cites W2048930761 @default.
- W3212967504 cites W2050271125 @default.
- W3212967504 cites W2052214918 @default.
- W3212967504 cites W2052622892 @default.
- W3212967504 cites W2059655994 @default.
- W3212967504 cites W2062378136 @default.
- W3212967504 cites W2065724668 @default.
- W3212967504 cites W2066207556 @default.
- W3212967504 cites W2066725077 @default.
- W3212967504 cites W2068554936 @default.
- W3212967504 cites W2072301714 @default.
- W3212967504 cites W2072696221 @default.
- W3212967504 cites W2073624281 @default.
- W3212967504 cites W2079083056 @default.
- W3212967504 cites W2082261245 @default.
- W3212967504 cites W2083681924 @default.
- W3212967504 cites W2090575626 @default.
- W3212967504 cites W2090941304 @default.
- W3212967504 cites W2091324204 @default.
- W3212967504 cites W2091589417 @default.
- W3212967504 cites W2091884933 @default.
- W3212967504 cites W2092772731 @default.
- W3212967504 cites W2095059919 @default.
- W3212967504 cites W2096474273 @default.
- W3212967504 cites W2098646234 @default.
- W3212967504 cites W2099133435 @default.
- W3212967504 cites W2099558279 @default.
- W3212967504 cites W2100867316 @default.
- W3212967504 cites W2101762911 @default.
- W3212967504 cites W2104306807 @default.
- W3212967504 cites W2104428288 @default.
- W3212967504 cites W2107942229 @default.
- W3212967504 cites W2113317108 @default.
- W3212967504 cites W2115373725 @default.
- W3212967504 cites W2116948062 @default.
- W3212967504 cites W2117672421 @default.
- W3212967504 cites W2125738893 @default.
- W3212967504 cites W2125872855 @default.
- W3212967504 cites W2132611682 @default.
- W3212967504 cites W2133529176 @default.
- W3212967504 cites W2133588441 @default.
- W3212967504 cites W2134814870 @default.
- W3212967504 cites W2135325359 @default.
- W3212967504 cites W2135404101 @default.
- W3212967504 cites W2136414528 @default.
- W3212967504 cites W2137769552 @default.
- W3212967504 cites W2141808811 @default.
- W3212967504 cites W2142337464 @default.
- W3212967504 cites W2147882701 @default.