Matches in SemOpenAlex for { <https://semopenalex.org/work/W3212978239> ?p ?o ?g. }
- W3212978239 abstract "The underlying mechanisms that promote precise spiking in upper motor neurons controlling fine motor skills are not well understood. Here we report that projection neurons in the adult zebra finch song nucleus RA display robust high-frequency firing, ultra-narrow spike waveforms, superfast Na+ current inactivation kinetics, and large resurgent Na+ currents (INaR). These properties of songbird pallial motor neurons closely resemble those of specialized large pyramidal neurons in mammalian primary motor cortex. They emerge during the early phases of song development in males, but not females, coinciding with a complete switch of Na+ channel subunit expression from Navβ3 to Navβ4. Dynamic clamping and dialysis of Navβ4's C-terminal peptide into juvenile RA neurons provide evidence that Navβ4, and its associated INaR, promote neuronal excitability. We thus propose that INaR modulates the excitability of upper motor neurons that are required for the execution of fine motor skills." @default.
- W3212978239 created "2021-11-22" @default.
- W3212978239 creator A5019207063 @default.
- W3212978239 creator A5019320814 @default.
- W3212978239 creator A5026840167 @default.
- W3212978239 creator A5035894095 @default.
- W3212978239 creator A5054896002 @default.
- W3212978239 creator A5068469745 @default.
- W3212978239 date "2021-11-19" @default.
- W3212978239 modified "2023-10-09" @default.
- W3212978239 title "Resurgent Na+ currents promote ultrafast spiking in projection neurons that drive fine motor control" @default.
- W3212978239 cites W1514853979 @default.
- W3212978239 cites W1517796520 @default.
- W3212978239 cites W1537888364 @default.
- W3212978239 cites W1559620581 @default.
- W3212978239 cites W1735491326 @default.
- W3212978239 cites W1902126708 @default.
- W3212978239 cites W1907851660 @default.
- W3212978239 cites W1947753814 @default.
- W3212978239 cites W1963735148 @default.
- W3212978239 cites W1965772573 @default.
- W3212978239 cites W1966176181 @default.
- W3212978239 cites W1967449579 @default.
- W3212978239 cites W1967930676 @default.
- W3212978239 cites W1968495411 @default.
- W3212978239 cites W1969366595 @default.
- W3212978239 cites W1969797865 @default.
- W3212978239 cites W1974804647 @default.
- W3212978239 cites W197620425 @default.
- W3212978239 cites W1977716114 @default.
- W3212978239 cites W1986726759 @default.
- W3212978239 cites W1990850200 @default.
- W3212978239 cites W1993142358 @default.
- W3212978239 cites W1993501461 @default.
- W3212978239 cites W1996739924 @default.
- W3212978239 cites W2004085402 @default.
- W3212978239 cites W2004132309 @default.
- W3212978239 cites W2005039077 @default.
- W3212978239 cites W2005373669 @default.
- W3212978239 cites W2007114612 @default.
- W3212978239 cites W2012041126 @default.
- W3212978239 cites W2018719316 @default.
- W3212978239 cites W2019593726 @default.
- W3212978239 cites W2020698686 @default.
- W3212978239 cites W2022105630 @default.
- W3212978239 cites W2024253734 @default.
- W3212978239 cites W2031404919 @default.
- W3212978239 cites W2031445919 @default.
- W3212978239 cites W2036072557 @default.
- W3212978239 cites W2037156065 @default.
- W3212978239 cites W2039479350 @default.
- W3212978239 cites W2040640404 @default.
- W3212978239 cites W2044364924 @default.
- W3212978239 cites W2047110455 @default.
- W3212978239 cites W2048571561 @default.
- W3212978239 cites W2049476099 @default.
- W3212978239 cites W2051204971 @default.
- W3212978239 cites W2051731737 @default.
- W3212978239 cites W2052407013 @default.
- W3212978239 cites W2052801529 @default.
- W3212978239 cites W2053178428 @default.
- W3212978239 cites W2058495600 @default.
- W3212978239 cites W2058498100 @default.
- W3212978239 cites W2067330717 @default.
- W3212978239 cites W2067392866 @default.
- W3212978239 cites W2069175658 @default.
- W3212978239 cites W2070754581 @default.
- W3212978239 cites W2071876445 @default.
- W3212978239 cites W2073951840 @default.
- W3212978239 cites W2075125238 @default.
- W3212978239 cites W2076903761 @default.
- W3212978239 cites W2077711469 @default.
- W3212978239 cites W2081136489 @default.
- W3212978239 cites W2085647160 @default.
- W3212978239 cites W2087805550 @default.
- W3212978239 cites W2094422723 @default.
- W3212978239 cites W2095478325 @default.
- W3212978239 cites W2096519870 @default.
- W3212978239 cites W2099850531 @default.
- W3212978239 cites W2102922842 @default.
- W3212978239 cites W2104895781 @default.
- W3212978239 cites W2105925739 @default.
- W3212978239 cites W2107781114 @default.
- W3212978239 cites W2114933644 @default.
- W3212978239 cites W2115002538 @default.
- W3212978239 cites W2120843707 @default.
- W3212978239 cites W2123491442 @default.
- W3212978239 cites W2131279491 @default.
- W3212978239 cites W2133147654 @default.
- W3212978239 cites W2137001862 @default.
- W3212978239 cites W2145455464 @default.
- W3212978239 cites W2146841999 @default.
- W3212978239 cites W2153967918 @default.
- W3212978239 cites W2157719421 @default.
- W3212978239 cites W2162185357 @default.
- W3212978239 cites W2163318624 @default.
- W3212978239 cites W2163956293 @default.
- W3212978239 cites W2164189343 @default.
- W3212978239 cites W2164990192 @default.
- W3212978239 cites W2167279371 @default.