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- W3213006045 abstract "Natural nanomachines like the F1/F0-ATPase contain protein components that undergo rotation relative to each other. Designing such mechanically constrained nanoscale protein architectures with internal degrees of freedom is an outstanding challenge for computational protein design. Here we explore the de novo construction of protein rotary machinery from designed axle and ring components. Using cryoelectron microscopy, we find that axle-ring systems assemble as designed and populate diverse rotational states depending on symmetry match or mismatch and the designed interface energy landscape. These mechanical systems with internal rotational degrees of freedom are a step towards the systematic design of genetically encodable nanomachines." @default.
- W3213006045 created "2021-11-22" @default.
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- W3213006045 date "2021-11-12" @default.
- W3213006045 modified "2023-10-10" @default.
- W3213006045 title "Computational design of nanoscale rotational mechanics in de novo protein assemblies" @default.
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- W3213006045 doi "https://doi.org/10.1101/2021.11.11.468255" @default.
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