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- W3213031683 abstract "Abstract Conjugate vaccine platform is a promising strategy to overcome the poor immunogenicity of bacterial polysaccharide antigens in infants and children. A carrier protein in conjugate vaccines works not only as an immune stimulator to polysaccharide, but also as an immunogen; with the latter generally not considered as a measured outcome in real world. Here, we probed the potential of a conjugate vaccine platform to induce enhanced immunogenicity of a truncated rotavirus spike protein ΔVP8*. ΔVP8* was covalently conjugated to Vi capsular polysaccharide (Vi) of Salmonella Typhi to develop a bivalent vaccine, termed Vi-ΔVP8*. Our results demonstrated that the Vi-ΔVP8* vaccine can induce specific immune responses against both antigens in immunized mice. The conjugate vaccine elicits high antibody titers and functional antibodies against S . Typhi and Rotavirus (RV) when compared to immunization with a single antigen. Together, these results indicate that Vi-ΔVP8* is a potent and immunogenic vaccine candidate, thus strengthening the potential of conjugate vaccine platform with enhanced immune responses to carrier protein, including ΔVP8*." @default.
- W3213031683 created "2021-11-22" @default.
- W3213031683 creator A5019452837 @default.
- W3213031683 creator A5020082088 @default.
- W3213031683 creator A5041512465 @default.
- W3213031683 creator A5056148684 @default.
- W3213031683 creator A5078646276 @default.
- W3213031683 creator A5084358780 @default.
- W3213031683 date "2021-11-11" @default.
- W3213031683 modified "2023-10-16" @default.
- W3213031683 title "Rotavirus spike protein ΔVP8* as a novel carrier protein for conjugate vaccine platform with demonstrated antigenic potential for use as bivalent vaccine" @default.
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- W3213031683 doi "https://doi.org/10.1038/s41598-021-01549-z" @default.