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- W3213048796 abstract "<h3>Introduction</h3> Endoscopic surveillance for Barrett’s Oesophagus (BE) has been indefinitely postponed due to the COVID-19 pandemic (Rees Clin Med 2020). As well as the potential for missed progression to dysplasia, the negative impact on patients’ quality of life is immeasurable. The Cytosponge® is a minimally invasive cell sampling device which to date has been researched in screening for BE (Ross-Innes Lan Gastr Hep 2017). We describe the first worldwide use of the Cytosponge® outside a clinical trial to triage BE surveillance patients unable to undergo endoscopy due to COVID-19. <h3>Methods</h3> Consecutive patients with non-dysplastic BE (NDBE) who were overdue endoscopy were invited to have the Cytosponge®. The sample was analysed for TFF3 (a marker of intestinal metaplasia), cellular atypia and p53. It was carried using minimal personal protective equipment (PPE) as it was not deemed to be an aerosol generating procedure (AGP). <h3>Results</h3> 60 patients have undergone the Cytosponge® procedure to date. Most patients (58, 97%) swallowed the device and in 4 was a result not possible (2 - unable to swallow the Cytosponge®, 2 - sample not analysable/sponge did not enter stomach). No complications were encountered. 40 patients (71%) had a either a low-risk result (TFF3 positive only – 26) or required a repeat Cytosponge® (TFF3/atypia/p53 negative or equivocal – 14). 16 patients (29%) needed an endoscopy within 3 months (cellular atypia – 12, p53 & cellular atypia – 4). 14 of these patients have since had an endoscopy of which 7 had a new diagnosis of dysplasia (indefinite – 2, low grade dysplasia, LGD – 4, intramucosal adenocarcinoma, 1) (Table 1). <h3>Conclusions</h3> The Cytosponge® has proved to be an acceptable non-endoscopic tool for patients with BE under surveillance where endoscopy is not possible. Preliminary data are promising to detect dysplasia and triage patients to endoscopy early. Further large scale, longitudinal follow-up is needed." @default.
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- W3213048796 date "2021-11-01" @default.
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- W3213048796 title "HFR-1 Cytosponge as a risk stratification tool in patients overdue barrett’s surveillance due to Covid-19" @default.
- W3213048796 doi "https://doi.org/10.1136/gutjnl-2021-bsg.60" @default.
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