FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213103088> ?p ?o ?g. }

• W3213103088 endingPage "4427" @default.
• W3213103088 startingPage "4416" @default.
• W3213103088 abstract "The discovery of new therapeutic agents for ischemic stroke remains an urgent need. Here, we identified a novel phenyl carboxylic acid derivative, n-pentyl 4-(3,4-dihydroxyphenyl)-4-oxobutanoate (PDPOB), with anti-ischemic activities. The in vitro anti-ischemic neuroprotective and anti-inflammatory capacities of PDPOB were investigated using neuronal cells suffering from oxygen-glucose deprivation/reperfusion (OGD/R) and microglial cells stimulated by lipopolysaccharide (LPS). PDPOB attenuated the OGD/R-evoked cellular damage of SH-SY5Y cells and primary cortical neurons in a concentration-dependent manner. Likewise, PDPOB displayed protective roles against OGD/R-evoked multiaspect neuronal deterioration in SH-SY5Y cells, as evidenced by alleviated mitochondrial dysfunction, oxidative stress, and apoptosis. A further study unveiled the accelerated phosphorylation of protein kinase B (AKT) by PDPOB treatment, while blockade of phosphoinositide 3-kinase (PI3K)/AKT signaling substantially diminished the neuroprotective capacities of PDPOB. Additionally, the PDPOB pretreatment dampened the LPS-evoked neuroinflammation in BV2 cells, characterized by the suppressed secretion of nitric oxide (NO) and proinflammatory cytokines, as well as normalized expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Western blotting further revealed that PDPOB abated the overabundant phosphorylation of the extracellular signal-regulated kinase (ERK), c-Jun-N-terminal kinase (JNK), and p38 in LPS-exposed BV2 cells. The intravenous application of PDPOB (30 mg/kg, single dose) attenuated ipsilateral cerebral infarction in middle cerebral artery occlusion (MCAO) rats, accompanied by recovered neurological behaviors. Collectively, the above observations provided substantial evidence for the favorable properties and mechanistic explanations of PDPOB in the regulation of ischemia-associated neuronal injury and microglial inflammation, which may furnish ideas for the discovery of new therapeutic strategies against cerebral ischemia." @default.
• W3213103088 created "2021-11-22" @default.
• W3213103088 creator A5002274462 @default.
• W3213103088 creator A5003940479 @default.
• W3213103088 creator A5007684366 @default.
• W3213103088 creator A5013215616 @default.
• W3213103088 creator A5016087217 @default.
• W3213103088 creator A5030446424 @default.
• W3213103088 creator A5044750543 @default.
• W3213103088 creator A5046597133 @default.
• W3213103088 creator A5051766913 @default.
• W3213103088 creator A5075477560 @default.
• W3213103088 creator A5075786756 @default.
• W3213103088 creator A5083372778 @default.
• W3213103088 date "2021-11-10" @default.
• W3213103088 modified "2023-10-13" @default.
• W3213103088 title "PDPOB Exerts Multiaspect Anti-Ischemic Effects Associated with the Regulation of PI3K/AKT and MAPK Signaling Pathways" @default.
• W3213103088 cites W1488524129 @default.
• W3213103088 cites W1598408991 @default.
• W3213103088 cites W1784761870 @default.
• W3213103088 cites W1964483580 @default.
• W3213103088 cites W1990233817 @default.
• W3213103088 cites W1997064745 @default.
• W3213103088 cites W2001893593 @default.
• W3213103088 cites W2021715667 @default.
• W3213103088 cites W2028653609 @default.
• W3213103088 cites W2035221144 @default.
• W3213103088 cites W2040831177 @default.
• W3213103088 cites W2042938039 @default.
• W3213103088 cites W2052894007 @default.
• W3213103088 cites W2058138221 @default.
• W3213103088 cites W2067543666 @default.
• W3213103088 cites W2074087753 @default.
• W3213103088 cites W2078861609 @default.
• W3213103088 cites W2103278596 @default.
• W3213103088 cites W2112505121 @default.
• W3213103088 cites W2114918609 @default.
• W3213103088 cites W2125619731 @default.
• W3213103088 cites W2125904354 @default.
• W3213103088 cites W2134128650 @default.
• W3213103088 cites W2136781825 @default.
• W3213103088 cites W2290914621 @default.
• W3213103088 cites W2325707043 @default.
• W3213103088 cites W2351673993 @default.
• W3213103088 cites W2540166269 @default.
• W3213103088 cites W2589680782 @default.
• W3213103088 cites W2590345134 @default.
• W3213103088 cites W2592462728 @default.
• W3213103088 cites W2601018600 @default.
• W3213103088 cites W2612886875 @default.
• W3213103088 cites W2625777374 @default.
• W3213103088 cites W2746951261 @default.
• W3213103088 cites W2790043087 @default.
• W3213103088 cites W2809315273 @default.
• W3213103088 cites W2915514667 @default.
• W3213103088 cites W2916872969 @default.
• W3213103088 cites W2920011597 @default.
• W3213103088 cites W2949122321 @default.
• W3213103088 cites W2959218190 @default.
• W3213103088 cites W2967707167 @default.
• W3213103088 cites W2984328295 @default.
• W3213103088 cites W3032620766 @default.
• W3213103088 cites W3170059866 @default.
• W3213103088 cites W345867142 @default.
• W3213103088 cites W98021116 @default.
• W3213103088 doi "https://doi.org/10.1021/acschemneuro.1c00459" @default.
• W3213103088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34755509" @default.
• W3213103088 hasPublicationYear "2021" @default.
• W3213103088 type Work @default.
• W3213103088 sameAs 3213103088 @default.
• W3213103088 citedByCount "0" @default.
• W3213103088 crossrefType "journal-article" @default.
• W3213103088 hasAuthorship W3213103088A5002274462 @default.
• W3213103088 hasAuthorship W3213103088A5003940479 @default.
• W3213103088 hasAuthorship W3213103088A5007684366 @default.
• W3213103088 hasAuthorship W3213103088A5013215616 @default.
• W3213103088 hasAuthorship W3213103088A5016087217 @default.
• W3213103088 hasAuthorship W3213103088A5030446424 @default.
• W3213103088 hasAuthorship W3213103088A5044750543 @default.
• W3213103088 hasAuthorship W3213103088A5046597133 @default.
• W3213103088 hasAuthorship W3213103088A5051766913 @default.
• W3213103088 hasAuthorship W3213103088A5075477560 @default.
• W3213103088 hasAuthorship W3213103088A5075786756 @default.
• W3213103088 hasAuthorship W3213103088A5083372778 @default.
• W3213103088 hasConcept C126322002 @default.
• W3213103088 hasConcept C164027704 @default.
• W3213103088 hasConcept C184235292 @default.
• W3213103088 hasConcept C185592680 @default.
• W3213103088 hasConcept C25498285 @default.
• W3213103088 hasConcept C2776914184 @default.
• W3213103088 hasConcept C2777622882 @default.
• W3213103088 hasConcept C51551487 @default.
• W3213103088 hasConcept C519581460 @default.
• W3213103088 hasConcept C55493867 @default.
• W3213103088 hasConcept C57074206 @default.
• W3213103088 hasConcept C62478195 @default.
• W3213103088 hasConcept C71924100 @default.
• W3213103088 hasConcept C75217442 @default.

• next