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- W3213147930 endingPage "100908" @default.
- W3213147930 startingPage "100908" @default.
- W3213147930 abstract "Acute lymphoblastic leukemia (ALL) is a malignancy of lymphoid progenitor cells occurring at an annual incidence rate of approximately 1.1 to 2.1 per 100,000 person-years globally. Approximately 40% of annual ALL cases occur in adults, yet estimated 5-year overall survival rates are about 40% to 50% in adults (and vary broadly by age) compared with 90% in children. Although the addition and/or intensification of asparaginase as a key treatment strategy for pediatric ALL is well recognized, further research is needed to clarify the benefit/risk ratio in adult patients with ALL. This review emphasizes the importance of efficient management of adverse events to increase asparaginase efficacy and explores novel strategies for optimizing asparaginase treatment, including new formulations of asparaginase, pharmacokinetic-based dosing, and pharmacogenetic profiling. Upcoming results of adult ALL trials should further clarify the role of asparaginase, building on the results of the large NOPHO 2008, CALGB 10403, GRAALL-2005, GMALL 07/2003, and UKALL14 trials." @default.
- W3213147930 created "2021-11-22" @default.
- W3213147930 creator A5005939966 @default.
- W3213147930 creator A5021277289 @default.
- W3213147930 creator A5067318724 @default.
- W3213147930 creator A5076973611 @default.
- W3213147930 date "2022-05-01" @default.
- W3213147930 modified "2023-09-30" @default.
- W3213147930 title "Optimizing use of L-asparaginase–based treatment of adults with acute lymphoblastic leukemia" @default.
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