FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213152864> ?p ?o ?g. }

• W3213152864 abstract "Rationale: Influenza A virus (IAV) and SARS-CoV-2 are both acute respiratory viruses currently circulating in the human population. Prior IAV infection enhances SARS-CoV-2 infectivity and lung pathogenesis in mice; however, underlying mechanisms and the extent that co-infection leads to involvement of other organs in disease severity remains unknown.Objective: Herein, we investigated the impact of prior IAV infection on SARS-CoV-2 pathogenesis and cardiomyocyte function.Methods and Results: IAV infection in human primary lung epithelial cells, lung fibroblasts, macrophages, cardiac fibroblasts, and hiPSC-Cardiomyocytes enhances the expression of, the SARS-CoV-2 receptor ACE2. Also, we found that IAV infection enhances levels of ACE2 in the lungs of mice and humans. Interestingly, we detected poorly glycosylated ACE2 in A549 lung cells, primary lung epithelial cells, and cardiac fibroblasts. In contrast, expression of a heavily glycosylated form of ACE2 is induced by IAV infection in cardiomyocytes. In all cell types, IAV infection enhances SARS-CoV-2 spike protein binding and viral entry. However, efficient SARS-CoV-2 replication was uniquely inhibited in cardiomyocytes. Glycosylation of ACE2 correlated with enzymatic conversion of its substrate Ang II, induction of eNOS and nitric oxide production, providing a mechanistic underpinning for restricted viral replication in cardiomyocytes.Conclusions: Our results indicate that IAV-mediated induction of ACE2 is double-edged, providing increased risk for SARS-CoV-2 coinfection in human  lung epithelial cells and cardiac fibroblasts , while limiting SARS-CoV-2 replication in cardiomyocytes. We conclude that differential glycosylation of ACE2 may be a molecular determinant- not of SARS-CoV-2 infection, but of replication.Funding: The work was supported by NIH grants AI 146252 and AI 146690.Declaration of Interests: The authors declare that they have no conflict of interest.Ethics Approval Statement: All procedures were approved by the OSU IACUC.We have obtained ethics approval from the Ohio State University, The Institutional Animal Care and Use Committee (#20160100-R1), Institutional Biosafety Committee (#20200135) for animal work and Institutional Review Board (#2020H0222) for human subjects." @default.
• W3213152864 created "2021-11-22" @default.
• W3213152864 creator A5009709203 @default.
• W3213152864 creator A5013773943 @default.
• W3213152864 creator A5017664556 @default.
• W3213152864 creator A5020155400 @default.
• W3213152864 creator A5043420038 @default.
• W3213152864 creator A5051805578 @default.
• W3213152864 creator A5083888976 @default.
• W3213152864 creator A5085477439 @default.
• W3213152864 creator A5090657616 @default.
• W3213152864 date "2021-01-01" @default.
• W3213152864 modified "2023-09-27" @default.
• W3213152864 title "Influenza A Virus Modulates ACE2 Expression and SARS-CoV-2 Infectivity in Human Cardiomyocytes" @default.
• W3213152864 cites W1997001042 @default.
• W3213152864 cites W1998964868 @default.
• W3213152864 cites W2015093606 @default.
• W3213152864 cites W2025750116 @default.
• W3213152864 cites W2064163159 @default.
• W3213152864 cites W2072011260 @default.
• W3213152864 cites W2087540023 @default.
• W3213152864 cites W2163107668 @default.
• W3213152864 cites W2169328873 @default.
• W3213152864 cites W2411823338 @default.
• W3213152864 cites W2760970111 @default.
• W3213152864 cites W2968155130 @default.
• W3213152864 cites W2970299008 @default.
• W3213152864 cites W3014027512 @default.
• W3213152864 cites W3014622337 @default.
• W3213152864 cites W3015336926 @default.
• W3213152864 cites W3015726950 @default.
• W3213152864 cites W3015772943 @default.
• W3213152864 cites W3016808868 @default.
• W3213152864 cites W3024126428 @default.
• W3213152864 cites W3036500399 @default.
• W3213152864 cites W3043975336 @default.
• W3213152864 cites W3045195423 @default.
• W3213152864 cites W3047895079 @default.
• W3213152864 cites W3087106210 @default.
• W3213152864 cites W3088401235 @default.
• W3213152864 cites W3093210439 @default.
• W3213152864 cites W3095150813 @default.
• W3213152864 cites W3118995069 @default.
• W3213152864 cites W3120417857 @default.
• W3213152864 cites W3121601491 @default.
• W3213152864 cites W3131708313 @default.
• W3213152864 doi "https://doi.org/10.2139/ssrn.3952087" @default.
• W3213152864 hasPublicationYear "2021" @default.
• W3213152864 type Work @default.
• W3213152864 sameAs 3213152864 @default.
• W3213152864 citedByCount "0" @default.
• W3213152864 crossrefType "journal-article" @default.
• W3213152864 hasAuthorship W3213152864A5009709203 @default.
• W3213152864 hasAuthorship W3213152864A5013773943 @default.
• W3213152864 hasAuthorship W3213152864A5017664556 @default.
• W3213152864 hasAuthorship W3213152864A5020155400 @default.
• W3213152864 hasAuthorship W3213152864A5043420038 @default.
• W3213152864 hasAuthorship W3213152864A5051805578 @default.
• W3213152864 hasAuthorship W3213152864A5083888976 @default.
• W3213152864 hasAuthorship W3213152864A5085477439 @default.
• W3213152864 hasAuthorship W3213152864A5090657616 @default.
• W3213152864 hasConcept C106358424 @default.
• W3213152864 hasConcept C142724271 @default.
• W3213152864 hasConcept C159047783 @default.
• W3213152864 hasConcept C2522874641 @default.
• W3213152864 hasConcept C2777546802 @default.
• W3213152864 hasConcept C2779134260 @default.
• W3213152864 hasConcept C3007834351 @default.
• W3213152864 hasConcept C3008058167 @default.
• W3213152864 hasConcept C3020799909 @default.
• W3213152864 hasConcept C524204448 @default.
• W3213152864 hasConcept C71924100 @default.
• W3213152864 hasConcept C86803240 @default.
• W3213152864 hasConcept C89423630 @default.
• W3213152864 hasConceptScore W3213152864C106358424 @default.
• W3213152864 hasConceptScore W3213152864C142724271 @default.
• W3213152864 hasConceptScore W3213152864C159047783 @default.
• W3213152864 hasConceptScore W3213152864C2522874641 @default.
• W3213152864 hasConceptScore W3213152864C2777546802 @default.
• W3213152864 hasConceptScore W3213152864C2779134260 @default.
• W3213152864 hasConceptScore W3213152864C3007834351 @default.
• W3213152864 hasConceptScore W3213152864C3008058167 @default.
• W3213152864 hasConceptScore W3213152864C3020799909 @default.
• W3213152864 hasConceptScore W3213152864C524204448 @default.
• W3213152864 hasConceptScore W3213152864C71924100 @default.
• W3213152864 hasConceptScore W3213152864C86803240 @default.
• W3213152864 hasConceptScore W3213152864C89423630 @default.
• W3213152864 hasLocation W32131528641 @default.
• W3213152864 hasOpenAccess W3213152864 @default.
• W3213152864 hasPrimaryLocation W32131528641 @default.
• W3213152864 hasRelatedWork W1953426278 @default.
• W3213152864 hasRelatedWork W2027511035 @default.
• W3213152864 hasRelatedWork W2053245798 @default.
• W3213152864 hasRelatedWork W2076100628 @default.
• W3213152864 hasRelatedWork W2088644387 @default.
• W3213152864 hasRelatedWork W2139087689 @default.
• W3213152864 hasRelatedWork W2169137691 @default.
• W3213152864 hasRelatedWork W3118214743 @default.
• W3213152864 hasRelatedWork W3127693599 @default.
• W3213152864 hasRelatedWork W4210401150 @default.

• next