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• W3213167957 endingPage "2100291" @default.
• W3213167957 startingPage "2100291" @default.
• W3213167957 abstract "This study describes the synthesis and evaluation of different imprinted hydrogels using ribavirin as template molecule. Ribavirin serves as a model molecule because it possesses a broad-spectrum antiviral effect against RNA viruses, which are expected as emerging viruses. The choice of monomers enables to stabilize the pre-polymerization complex and to synthesize biocompatible polymers. Predictive studies as well as experimental works conclude similar results on best ribavirin:monomers ratios. Thus, materials exhibit high selective cavities toward ribavirin. These affinities allow to show release profiles drastically different from the non-imprinted ones at two temperatures. The imprinted materials show a sustained profile able to release antiviral for more than 24 h. The hydrogels obtained are biocompatible with model cells retained, human lung epithelial BEAS-2B cells. Cell viability is excellent and pro-inflammatory response is insignificant when imprinted polymers are incubated with cells. Finally, viral tests carried out on Influenza A infected lung cells show that imprinted delivery systems delivering 1 to 3 µg of antiviral have the same efficiency as a medium containing 30 µg mL-1 of active agent. As a very interesting result, the molecularly imprinted polymers as drug delivery systems allow to increase the local concentration of antiviral, to improve their delivery when its bioavailability is low." @default.
• W3213167957 created "2021-11-22" @default.
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• W3213167957 date "2021-11-21" @default.
• W3213167957 modified "2023-09-30" @default.
• W3213167957 title "Molecularly Imprinted Hydrogels Selective to Ribavirin as New Drug Delivery Systems to Improve Efficiency of Antiviral Nucleoside Analogue: A Proof‐of‐Concept Study with Influenza A Virus" @default.
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• W3213167957 doi "https://doi.org/10.1002/mabi.202100291" @default.
• W3213167957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34773718" @default.
• W3213167957 hasPublicationYear "2021" @default.
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