FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213236989> ?p ?o ?g. }

• W3213236989 endingPage "106982" @default.
• W3213236989 startingPage "106982" @default.
• W3213236989 abstract "Perfluoroalkyl substances (PFASs) are synthetic chemicals widely used in industrial and consumer products. The environmental spreading of PFASs raises concerns for their impact on human health. In particular, the bioaccumulation in humans due to environmental exposure has been reported also in total brain samples and PFAS exposure has been associated with neurodevelopmental disorders. In this study we aimed to investigate the specific PFAS bioaccumulation in different brain areas. Our data reported major accumulation in the brainstem region, which is richly populated by dopaminergic neurons (DNs), in brain autopsy samples from people resident in a PFAS-polluted area of Italy. Since DNs are the main source of dopamine (DA) in the mammalian central nervous system (CNS), we evaluated the possible functional consequences of perfluoro-octanoic acid (PFOA) exposure in a human model of DNs obtained by differentiation of human induced pluripotent stem cells (hiPSCs). Particularly, we analyzed the specific effect of the exposure to PFOA for 24 h, at the concentration of 10 ng/ml, at 3 different steps of dopaminergic differentiation: the neuronal commitment phase (DP1), the neuronal precursor phase (DP2) and the mature dopaminergic differentiation phase (DP3). Interestingly, compared to untreated cells, exposure to PFOA was associated with a reduced expression of Tyrosine Hydroxylase (TH) and Neurofilament Heavy (NFH), both markers of dopaminergic maturation at DP2 phase. In addition, cells at DP3 phase exposed to PFOA showed a severe reduction in the expression of the Dopamine Transporter (DAT), functionally involved in pre-synaptic dopamine reuptake. In this proof-of-concept study we show a significant impact of PFOA exposure, mainly on the most sensitive stage of neural dopaminergic differentiation, prompting the way for further investigations more directly relevant to risk assessment of these chemicals." @default.
• W3213236989 created "2021-11-22" @default.
• W3213236989 creator A5000666523 @default.
• W3213236989 creator A5005239262 @default.
• W3213236989 creator A5005998619 @default.
• W3213236989 creator A5014371364 @default.
• W3213236989 creator A5023998370 @default.
• W3213236989 creator A5026484851 @default.
• W3213236989 creator A5050169272 @default.
• W3213236989 creator A5051462118 @default.
• W3213236989 creator A5052133972 @default.
• W3213236989 creator A5064027569 @default.
• W3213236989 creator A5064328155 @default.
• W3213236989 creator A5072833956 @default.
• W3213236989 date "2022-01-01" @default.
• W3213236989 modified "2023-10-14" @default.
• W3213236989 title "Impairment of human dopaminergic neurons at different developmental stages by perfluoro-octanoic acid (PFOA) and differential human brain areas accumulation of perfluoroalkyl chemicals" @default.
• W3213236989 cites W1694693019 @default.
• W3213236989 cites W1972859890 @default.
• W3213236989 cites W1975800091 @default.
• W3213236989 cites W1976770880 @default.
• W3213236989 cites W1985250447 @default.
• W3213236989 cites W1989943714 @default.
• W3213236989 cites W1995048806 @default.
• W3213236989 cites W1996719014 @default.
• W3213236989 cites W2000476420 @default.
• W3213236989 cites W2004809711 @default.
• W3213236989 cites W2008057044 @default.
• W3213236989 cites W2016223385 @default.
• W3213236989 cites W2022879961 @default.
• W3213236989 cites W2029026103 @default.
• W3213236989 cites W2045629032 @default.
• W3213236989 cites W2046694885 @default.
• W3213236989 cites W2063924260 @default.
• W3213236989 cites W2067168283 @default.
• W3213236989 cites W2067561304 @default.
• W3213236989 cites W2068337533 @default.
• W3213236989 cites W2070928735 @default.
• W3213236989 cites W2071411087 @default.
• W3213236989 cites W2071785843 @default.
• W3213236989 cites W2073925793 @default.
• W3213236989 cites W2083002282 @default.
• W3213236989 cites W2083115396 @default.
• W3213236989 cites W2097847411 @default.
• W3213236989 cites W2125049636 @default.
• W3213236989 cites W2127633965 @default.
• W3213236989 cites W2135349334 @default.
• W3213236989 cites W2162113700 @default.
• W3213236989 cites W2186651167 @default.
• W3213236989 cites W2315116887 @default.
• W3213236989 cites W2514378822 @default.
• W3213236989 cites W2521272618 @default.
• W3213236989 cites W2526847091 @default.
• W3213236989 cites W2547964794 @default.
• W3213236989 cites W2560312791 @default.
• W3213236989 cites W2575494223 @default.
• W3213236989 cites W2617249117 @default.
• W3213236989 cites W2746728159 @default.
• W3213236989 cites W2775800635 @default.
• W3213236989 cites W2786608785 @default.
• W3213236989 cites W2791402978 @default.
• W3213236989 cites W2898521203 @default.
• W3213236989 cites W2899631563 @default.
• W3213236989 cites W2913288723 @default.
• W3213236989 cites W2914843779 @default.
• W3213236989 cites W2937003714 @default.
• W3213236989 cites W2947803394 @default.
• W3213236989 cites W2951336142 @default.
• W3213236989 cites W2981772479 @default.
• W3213236989 cites W2990062575 @default.
• W3213236989 cites W2999007637 @default.
• W3213236989 cites W3000325218 @default.
• W3213236989 cites W3003448814 @default.
• W3213236989 cites W3007737736 @default.
• W3213236989 cites W3016803886 @default.
• W3213236989 cites W3087351650 @default.
• W3213236989 cites W3134781194 @default.
• W3213236989 cites W3158865531 @default.
• W3213236989 cites W3183551012 @default.
• W3213236989 cites W3190038158 @default.
• W3213236989 doi "https://doi.org/10.1016/j.envint.2021.106982" @default.
• W3213236989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34781208" @default.
• W3213236989 hasPublicationYear "2022" @default.
• W3213236989 type Work @default.
• W3213236989 sameAs 3213236989 @default.
• W3213236989 citedByCount "23" @default.
• W3213236989 countsByYear W32132369892022 @default.
• W3213236989 countsByYear W32132369892023 @default.
• W3213236989 crossrefType "journal-article" @default.
• W3213236989 hasAuthorship W3213236989A5000666523 @default.
• W3213236989 hasAuthorship W3213236989A5005239262 @default.
• W3213236989 hasAuthorship W3213236989A5005998619 @default.
• W3213236989 hasAuthorship W3213236989A5014371364 @default.
• W3213236989 hasAuthorship W3213236989A5023998370 @default.
• W3213236989 hasAuthorship W3213236989A5026484851 @default.
• W3213236989 hasAuthorship W3213236989A5050169272 @default.
• W3213236989 hasAuthorship W3213236989A5051462118 @default.
• W3213236989 hasAuthorship W3213236989A5052133972 @default.

• next