FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213237876> ?p ?o ?g. }

• W3213237876 endingPage "12291" @default.
• W3213237876 startingPage "12291" @default.
• W3213237876 abstract "As major components of spider venoms, neurotoxic peptides exhibit structural diversity, target specificity, and have great pharmaceutical potential. Deep learning may be an alternative to the laborious and time-consuming methods for identifying these peptides. However, the major hurdle in developing a deep learning model is the limited data on neurotoxic peptides. Here, we present a peptide data augmentation method that improves the recognition of neurotoxic peptides via a convolutional neural network model. The neurotoxic peptides were augmented with the known neurotoxic peptides from UniProt database, and the models were trained using a training set with or without the generated sequences to verify the augmented data. The model trained with the augmented dataset outperformed the one with the unaugmented dataset, achieving accuracy of 0.9953, precision of 0.9922, recall of 0.9984, and F1 score of 0.9953 in simulation dataset. From the set of all RNA transcripts of Callobius koreanus spider, we discovered neurotoxic peptides via the model, resulting in 275 putative peptides of which 252 novel sequences and only 23 sequences showing homology with the known peptides by Basic Local Alignment Search Tool. Among these 275 peptides, four were selected and shown to have neuromodulatory effects on the human neuroblastoma cell line SH-SY5Y. The augmentation method presented here may be applied to the identification of other functional peptides from biological resources with insufficient data." @default.
• W3213237876 created "2021-11-22" @default.
• W3213237876 creator A5016265803 @default.
• W3213237876 creator A5026351538 @default.
• W3213237876 creator A5036928861 @default.
• W3213237876 creator A5041456684 @default.
• W3213237876 creator A5057588480 @default.
• W3213237876 creator A5064187568 @default.
• W3213237876 creator A5070786021 @default.
• W3213237876 creator A5073631855 @default.
• W3213237876 creator A5088555849 @default.
• W3213237876 date "2021-11-13" @default.
• W3213237876 modified "2023-10-10" @default.
• W3213237876 title "A Deep Learning Approach with Data Augmentation to Predict Novel Spider Neurotoxic Peptides" @default.
• W3213237876 cites W1505191356 @default.
• W3213237876 cites W1788555922 @default.
• W3213237876 cites W1938099677 @default.
• W3213237876 cites W1966479384 @default.
• W3213237876 cites W1969344024 @default.
• W3213237876 cites W1989299599 @default.
• W3213237876 cites W1999574084 @default.
• W3213237876 cites W2006266675 @default.
• W3213237876 cites W2007366692 @default.
• W3213237876 cites W2010493890 @default.
• W3213237876 cites W2011657487 @default.
• W3213237876 cites W2021863863 @default.
• W3213237876 cites W2023303116 @default.
• W3213237876 cites W2036769084 @default.
• W3213237876 cites W2050559962 @default.
• W3213237876 cites W2075307204 @default.
• W3213237876 cites W2079141278 @default.
• W3213237876 cites W2100200388 @default.
• W3213237876 cites W2111734406 @default.
• W3213237876 cites W2124985265 @default.
• W3213237876 cites W2126419817 @default.
• W3213237876 cites W2142678478 @default.
• W3213237876 cites W2148992281 @default.
• W3213237876 cites W2159128192 @default.
• W3213237876 cites W2166992704 @default.
• W3213237876 cites W2168521460 @default.
• W3213237876 cites W2179438025 @default.
• W3213237876 cites W2549751681 @default.
• W3213237876 cites W2767170939 @default.
• W3213237876 cites W2789559913 @default.
• W3213237876 cites W2805627121 @default.
• W3213237876 cites W2806925460 @default.
• W3213237876 cites W2886149300 @default.
• W3213237876 cites W2906946803 @default.
• W3213237876 cites W2912990441 @default.
• W3213237876 cites W2922701384 @default.
• W3213237876 cites W2923909143 @default.
• W3213237876 cites W2935703330 @default.
• W3213237876 cites W2949841808 @default.
• W3213237876 cites W2954345736 @default.
• W3213237876 cites W2971658572 @default.
• W3213237876 cites W2979588939 @default.
• W3213237876 cites W2980183989 @default.
• W3213237876 cites W3025501158 @default.
• W3213237876 cites W3082096568 @default.
• W3213237876 cites W3136918052 @default.
• W3213237876 cites W3202393418 @default.
• W3213237876 doi "https://doi.org/10.3390/ijms222212291" @default.
• W3213237876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8619404" @default.
• W3213237876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34830173" @default.
• W3213237876 hasPublicationYear "2021" @default.
• W3213237876 type Work @default.
• W3213237876 sameAs 3213237876 @default.
• W3213237876 citedByCount "8" @default.
• W3213237876 countsByYear W32132378762022 @default.
• W3213237876 countsByYear W32132378762023 @default.
• W3213237876 crossrefType "journal-article" @default.
• W3213237876 hasAuthorship W3213237876A5016265803 @default.
• W3213237876 hasAuthorship W3213237876A5026351538 @default.
• W3213237876 hasAuthorship W3213237876A5036928861 @default.
• W3213237876 hasAuthorship W3213237876A5041456684 @default.
• W3213237876 hasAuthorship W3213237876A5057588480 @default.
• W3213237876 hasAuthorship W3213237876A5064187568 @default.
• W3213237876 hasAuthorship W3213237876A5070786021 @default.
• W3213237876 hasAuthorship W3213237876A5073631855 @default.
• W3213237876 hasAuthorship W3213237876A5088555849 @default.
• W3213237876 hasBestOaLocation W32132378761 @default.
• W3213237876 hasConcept C104317684 @default.
• W3213237876 hasConcept C108583219 @default.
• W3213237876 hasConcept C116834253 @default.
• W3213237876 hasConcept C119857082 @default.
• W3213237876 hasConcept C154945302 @default.
• W3213237876 hasConcept C202264299 @default.
• W3213237876 hasConcept C2779281246 @default.
• W3213237876 hasConcept C41008148 @default.
• W3213237876 hasConcept C51632099 @default.
• W3213237876 hasConcept C55493867 @default.
• W3213237876 hasConcept C59822182 @default.
• W3213237876 hasConcept C70721500 @default.
• W3213237876 hasConcept C81363708 @default.
• W3213237876 hasConcept C86803240 @default.
• W3213237876 hasConceptScore W3213237876C104317684 @default.
• W3213237876 hasConceptScore W3213237876C108583219 @default.
• W3213237876 hasConceptScore W3213237876C116834253 @default.

• next