Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213278439> ?p ?o ?g. }
- W3213278439 endingPage "1676" @default.
- W3213278439 startingPage "1676" @default.
- W3213278439 abstract "Homeobox genes encode transcription factors controlling basic developmental processes. The homeodomain is encoded by the homeobox and mediates sequence-specific DNA binding and interaction with cofactors, thus operating as a basic regulatory platform. Similarities in their homeobox sequences serve to arrange these genes in classes and subclasses, including NKL homeobox genes. In accordance with their normal functions, deregulated homeobox genes contribute to carcinogenesis along with hematopoietic malignancies. We have recently described the physiological expression of eleven NKL homeobox genes in the course of hematopoiesis and termed this gene expression pattern NKL-code. Due to the developmental impact of NKL homeobox genes these data suggest a key role for their activity in the normal regulation of hematopoietic cell differentiation including T-cells. On the other hand, aberrant overexpression of NKL-code members or ectopical activation of non-code members has been frequently reported in lymphoid and myeloid leukemia/lymphoma, demonstrating their oncogenic impact in the hematopoietic compartment. Here, we provide an overview of the NKL-code in normal hematopoiesis and discuss the oncogenic role of deregulated NKL homeobox genes in T-cell malignancies." @default.
- W3213278439 created "2021-11-22" @default.
- W3213278439 creator A5088371729 @default.
- W3213278439 date "2021-11-12" @default.
- W3213278439 modified "2023-09-27" @default.
- W3213278439 title "The Role of NKL Homeobox Genes in T-Cell Malignancies" @default.
- W3213278439 cites W1261941413 @default.
- W3213278439 cites W1554993474 @default.
- W3213278439 cites W1602845636 @default.
- W3213278439 cites W1844026860 @default.
- W3213278439 cites W1968235930 @default.
- W3213278439 cites W1970799659 @default.
- W3213278439 cites W1976734515 @default.
- W3213278439 cites W1982151423 @default.
- W3213278439 cites W1983698607 @default.
- W3213278439 cites W1985348819 @default.
- W3213278439 cites W1986232182 @default.
- W3213278439 cites W1988332053 @default.
- W3213278439 cites W1991208922 @default.
- W3213278439 cites W1991615434 @default.
- W3213278439 cites W1994791278 @default.
- W3213278439 cites W1995022717 @default.
- W3213278439 cites W1995601641 @default.
- W3213278439 cites W1995775187 @default.
- W3213278439 cites W2001163176 @default.
- W3213278439 cites W2003565087 @default.
- W3213278439 cites W2005729329 @default.
- W3213278439 cites W2008151377 @default.
- W3213278439 cites W2015840464 @default.
- W3213278439 cites W2016686483 @default.
- W3213278439 cites W2019326157 @default.
- W3213278439 cites W2023132454 @default.
- W3213278439 cites W2024693341 @default.
- W3213278439 cites W2024770693 @default.
- W3213278439 cites W2028682570 @default.
- W3213278439 cites W2028885330 @default.
- W3213278439 cites W2035444281 @default.
- W3213278439 cites W2039690398 @default.
- W3213278439 cites W2040171134 @default.
- W3213278439 cites W2040910893 @default.
- W3213278439 cites W2041360675 @default.
- W3213278439 cites W2043315520 @default.
- W3213278439 cites W2046477359 @default.
- W3213278439 cites W2047284392 @default.
- W3213278439 cites W2049049669 @default.
- W3213278439 cites W2054872825 @default.
- W3213278439 cites W2059215767 @default.
- W3213278439 cites W2067354565 @default.
- W3213278439 cites W2067631969 @default.
- W3213278439 cites W2068001725 @default.
- W3213278439 cites W2068203593 @default.
- W3213278439 cites W2069229152 @default.
- W3213278439 cites W2085479979 @default.
- W3213278439 cites W2087327395 @default.
- W3213278439 cites W2087369559 @default.
- W3213278439 cites W2098412979 @default.
- W3213278439 cites W2098915229 @default.
- W3213278439 cites W2099406248 @default.
- W3213278439 cites W2104090970 @default.
- W3213278439 cites W2105186755 @default.
- W3213278439 cites W2106000284 @default.
- W3213278439 cites W2108663844 @default.
- W3213278439 cites W2111786713 @default.
- W3213278439 cites W2113057585 @default.
- W3213278439 cites W2127184995 @default.
- W3213278439 cites W2127348961 @default.
- W3213278439 cites W2127754056 @default.
- W3213278439 cites W2130197297 @default.
- W3213278439 cites W2138143669 @default.
- W3213278439 cites W2141172480 @default.
- W3213278439 cites W2171056103 @default.
- W3213278439 cites W2231127685 @default.
- W3213278439 cites W2431559618 @default.
- W3213278439 cites W2549518011 @default.
- W3213278439 cites W2582879308 @default.
- W3213278439 cites W2586007098 @default.
- W3213278439 cites W2586380847 @default.
- W3213278439 cites W2622999795 @default.
- W3213278439 cites W2629772863 @default.
- W3213278439 cites W2773314453 @default.
- W3213278439 cites W2782306116 @default.
- W3213278439 cites W2790525055 @default.
- W3213278439 cites W2791502259 @default.
- W3213278439 cites W2796646673 @default.
- W3213278439 cites W2800326618 @default.
- W3213278439 cites W2897079763 @default.
- W3213278439 cites W2946886879 @default.
- W3213278439 cites W2948444256 @default.
- W3213278439 cites W2950429533 @default.
- W3213278439 cites W2954194261 @default.
- W3213278439 cites W2995551073 @default.
- W3213278439 cites W3037753076 @default.
- W3213278439 cites W3080985300 @default.
- W3213278439 cites W3088033748 @default.
- W3213278439 cites W3092523360 @default.
- W3213278439 cites W3127811565 @default.
- W3213278439 cites W3153945052 @default.
- W3213278439 cites W3165321811 @default.