Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213294857> ?p ?o ?g. }
- W3213294857 abstract "With the eye as a window to the brain, non-invasive fast screening of retinal nerve fibre layer thickness poses the opportunity for early detection of cognitive decline leading to dementia. Our objective is to determine whether performance in various neurocognitive tests has an association with itemized retinal nerve fibre layer thickness. Detailed investigation of associations factored in sex and eye-side. The large population-based LIFE-Adult study (Leipzig Research Centre for Civilization Diseases) was conducted at Leipzig University, Germany from 2011 to 2014. Randomly selected participants (N = 10 000) were drawn from population registry in an age- and gender-stratified manner, focusing on 40-80 years. Cognitive function was examined with the CERAD-NP Plus test-battery (Consortium to Establish a Registry for Alzheimer's Disease), Stroop-Test, Reading the Mind in the Eyes-Test and Multiple-Choice Vocabulary Intelligence Test. Circumpapillary retinal nerve fibre layer thickness was measured with Optical Coherence Tomography. Subjects with reliable measurements (≥50 B-scan repetitions, signal-to-noise-ratio ≥20 dB, ≤5% missing A-scans) and without clinical eye pathology (sample A) and additional exclusion due to conditions of the central nervous system (sample B) were evaluated. The relationship between cognitive function and retinal nerve fibre layer thickness was investigated for six segments: temporal, temporal-superior, temporal-inferior, nasal, nasal-superior and nasal-inferior. For comparison with other studies, global mean is given. Brain-side projection analysis links results to the corresponding brain hemisphere. We analysed 11 124 eyes of 6471 subjects [55.5 years of age (19.1-79.8 years), 46.9% male]. Low cognitive performance was predominantly associated with thinner retinal nerve fibre layer thickness. Correlation analysis indicated emphasis on global and temporally located effects. Multivariable regression analysis with adjustments (age, sex and scan radius) presented individual results for each test, differentiating between sex and eye-side. For instance, verbal fluency tests and Trail Making Test-B show stronger association in females; Trail Making Test-A shows right-eye dominance. Findings in Trail-Making-Test-A projected to left brain hemisphere, and the ratio incongruent to neutral in the Stroop test projected to right brain-hemisphere. Separate assessment for sex and eye-side is presented for the first time in a population-based study. Location-specific sectorial retinal nerve fibre layer thickness was found to be an indicator for cognitive performance, giving an option for early detection of cognitive decline and the potential of early treatment. The eye as a window to the brain was studied with optical coherence tomography and connected to cognition. Girbardt et al. report that thinner retinal nerve fibre layer thickness was found to be a meaningful index for poorer cognitive performance which presents the potential for prediction of future cognitive decline." @default.
- W3213294857 created "2021-11-22" @default.
- W3213294857 creator A5003871697 @default.
- W3213294857 creator A5011068135 @default.
- W3213294857 creator A5016092761 @default.
- W3213294857 creator A5019233149 @default.
- W3213294857 creator A5020270555 @default.
- W3213294857 creator A5025964385 @default.
- W3213294857 creator A5027776523 @default.
- W3213294857 creator A5033292535 @default.
- W3213294857 creator A5039738060 @default.
- W3213294857 creator A5045258788 @default.
- W3213294857 creator A5047341378 @default.
- W3213294857 creator A5047837989 @default.
- W3213294857 creator A5053891938 @default.
- W3213294857 creator A5057665448 @default.
- W3213294857 creator A5061869037 @default.
- W3213294857 creator A5066801947 @default.
- W3213294857 creator A5090849357 @default.
- W3213294857 date "2021-11-08" @default.
- W3213294857 modified "2023-09-23" @default.
- W3213294857 title "Reading cognition from the eyes—association of retinal nerve fiber layer thickness with cognitive performance in a population-based study" @default.
- W3213294857 cites W1507123469 @default.
- W3213294857 cites W1925629371 @default.
- W3213294857 cites W1989482166 @default.
- W3213294857 cites W1998128125 @default.
- W3213294857 cites W2000567681 @default.
- W3213294857 cites W2010674189 @default.
- W3213294857 cites W2017213597 @default.
- W3213294857 cites W2018784944 @default.
- W3213294857 cites W2024080336 @default.
- W3213294857 cites W2031047184 @default.
- W3213294857 cites W2032846091 @default.
- W3213294857 cites W2052978590 @default.
- W3213294857 cites W2056570486 @default.
- W3213294857 cites W2057177646 @default.
- W3213294857 cites W2064963539 @default.
- W3213294857 cites W2066225757 @default.
- W3213294857 cites W2067975928 @default.
- W3213294857 cites W2069658515 @default.
- W3213294857 cites W2070812752 @default.
- W3213294857 cites W2081463022 @default.
- W3213294857 cites W2085125680 @default.
- W3213294857 cites W2086338720 @default.
- W3213294857 cites W2093690346 @default.
- W3213294857 cites W2096337635 @default.
- W3213294857 cites W2096753835 @default.
- W3213294857 cites W2103738834 @default.
- W3213294857 cites W2106755343 @default.
- W3213294857 cites W2115427066 @default.
- W3213294857 cites W2134822928 @default.
- W3213294857 cites W2158106097 @default.
- W3213294857 cites W2158766477 @default.
- W3213294857 cites W2222563817 @default.
- W3213294857 cites W2290717151 @default.
- W3213294857 cites W2339231197 @default.
- W3213294857 cites W2516036889 @default.
- W3213294857 cites W2581573924 @default.
- W3213294857 cites W2590511362 @default.
- W3213294857 cites W2597079365 @default.
- W3213294857 cites W2750510345 @default.
- W3213294857 cites W2753321395 @default.
- W3213294857 cites W2755106885 @default.
- W3213294857 cites W2780037777 @default.
- W3213294857 cites W2791568464 @default.
- W3213294857 cites W2799450676 @default.
- W3213294857 cites W2810823800 @default.
- W3213294857 cites W2810823899 @default.
- W3213294857 cites W2898639674 @default.
- W3213294857 cites W2903546628 @default.
- W3213294857 cites W2943527878 @default.
- W3213294857 cites W2970399509 @default.
- W3213294857 cites W2976387010 @default.
- W3213294857 cites W2996421099 @default.
- W3213294857 cites W3014567250 @default.
- W3213294857 cites W3035333047 @default.
- W3213294857 cites W3037469088 @default.
- W3213294857 cites W3037998470 @default.
- W3213294857 cites W3046824724 @default.
- W3213294857 cites W3048464709 @default.
- W3213294857 cites W3134120952 @default.
- W3213294857 cites W6335717 @default.
- W3213294857 doi "https://doi.org/10.1093/braincomms/fcab258" @default.
- W3213294857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35350710" @default.
- W3213294857 hasPublicationYear "2021" @default.
- W3213294857 type Work @default.
- W3213294857 sameAs 3213294857 @default.
- W3213294857 citedByCount "6" @default.
- W3213294857 countsByYear W32132948572022 @default.
- W3213294857 countsByYear W32132948572023 @default.
- W3213294857 crossrefType "journal-article" @default.
- W3213294857 hasAuthorship W3213294857A5003871697 @default.
- W3213294857 hasAuthorship W3213294857A5011068135 @default.
- W3213294857 hasAuthorship W3213294857A5016092761 @default.
- W3213294857 hasAuthorship W3213294857A5019233149 @default.
- W3213294857 hasAuthorship W3213294857A5020270555 @default.
- W3213294857 hasAuthorship W3213294857A5025964385 @default.
- W3213294857 hasAuthorship W3213294857A5027776523 @default.
- W3213294857 hasAuthorship W3213294857A5033292535 @default.
- W3213294857 hasAuthorship W3213294857A5039738060 @default.