FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213302629> ?p ?o ?g. }

• W3213302629 abstract "<h3>Introduction and Objectives</h3> Idiopathic Pulmonary Fibrosis (IPF) has a median survival of ~ 2–3 years, but there is significant variability and hence difficulty in advising patients at a personal level. The full blood count (FBC) is readily accessible and gives a Red Cell Distribution Width (RDW), which describes the percentage variation in red cell size. The neutrophil and lymphocyte count can be used to calculate a ratio (NLR). Limited published work has evaluated the prognostic significance of these markers in IPF. Our aim was to assess longitudinal changes in RDW and NLR as potential prognosticators in IPF. <h3>Methods</h3> Patients with IPF were identified from the Royal Devon and Exeter Hospital (2005–2019). Data collected: baseline characteristics, survival, PFTs and FBC <6 months from diagnosis and 6–18 months during follow-up. Patients with insufficient data were excluded. Blood parameters were stratified into quartiles for subsequent Kaplan-Meier survival analyses, Mann-Whitney U-test and Spearman’s rank correlation. <h3>Results</h3> 131 patients were included in analysis. Median change/month for NLR (deltaNLR) and RDW (deltaRDW) were 0.17 and 0.02 respectively, indicating minimal longitudinal variation. Anti-fibrotic treatment did not modify deltaRDW or deltaNLR. However, stratifying by median deltaRDW significantly impacted on survival (median 33 months with deltaRDW>0.02 vs 59 months; P = 0.04). Median survival stratified on baseline RDW was 35 months (highest quartile) vs 47 months (1st-3rd quartiles) although this did not reach significance (P =0.1439). Median survival based on follow-up RDW was 25 months (highest quartile) vs 59 months (1st-3rd quartiles; P=0.0021) and this was negatively correlated with FVC (P=0.0056). Both baseline and follow-up NLR had significantly shorter median survival in the highest quartile (28 months; p<0.05) compared with 47 months (baseline 1st-3rd quartile) or 59 months (follow-up 1st-3rd quartile). FVC was negatively correlated to baseline NLR (P=0.0282). <h3>Conclusions</h3> RDW and NLR demonstrated significant relationships with survival and correlations with FVC. Increasing RDW resulted in poorer outcomes. Although limited by the small retrospective cohort, this data indicates that readily available FBC may have utility in prognostication and progression monitoring in IPF, independent of antifibrotic treatment. RDW may be confounded by co-morbidities; further work to assess this is warranted." @default.
• W3213302629 created "2021-11-22" @default.
• W3213302629 creator A5012996578 @default.
• W3213302629 creator A5036346717 @default.
• W3213302629 creator A5039771226 @default.
• W3213302629 creator A5063420958 @default.
• W3213302629 creator A5073445474 @default.
• W3213302629 creator A5073954288 @default.
• W3213302629 creator A5074581565 @default.
• W3213302629 creator A5074628390 @default.
• W3213302629 creator A5076198914 @default.
• W3213302629 creator A5086719422 @default.
• W3213302629 date "2021-11-01" @default.
• W3213302629 modified "2023-09-26" @default.
• W3213302629 title "P144 Red cell distribution width (RDW) and neutrophil lymphocyte ratio (NLR) as prognostic markers in idiopathic pulmonary fibrosis (IPF)" @default.
• W3213302629 doi "https://doi.org/10.1136/thorax-2021-btsabstracts.253" @default.
• W3213302629 hasPublicationYear "2021" @default.
• W3213302629 type Work @default.
• W3213302629 sameAs 3213302629 @default.
• W3213302629 citedByCount "0" @default.
• W3213302629 crossrefType "proceedings-article" @default.
• W3213302629 hasAuthorship W3213302629A5012996578 @default.
• W3213302629 hasAuthorship W3213302629A5036346717 @default.
• W3213302629 hasAuthorship W3213302629A5039771226 @default.
• W3213302629 hasAuthorship W3213302629A5063420958 @default.
• W3213302629 hasAuthorship W3213302629A5073445474 @default.
• W3213302629 hasAuthorship W3213302629A5073954288 @default.
• W3213302629 hasAuthorship W3213302629A5074581565 @default.
• W3213302629 hasAuthorship W3213302629A5074628390 @default.
• W3213302629 hasAuthorship W3213302629A5076198914 @default.
• W3213302629 hasAuthorship W3213302629A5086719422 @default.
• W3213302629 hasBestOaLocation W32133026291 @default.
• W3213302629 hasConcept C10515644 @default.
• W3213302629 hasConcept C126322002 @default.
• W3213302629 hasConcept C2777714996 @default.
• W3213302629 hasConcept C2777761686 @default.
• W3213302629 hasConcept C2778341716 @default.
• W3213302629 hasConcept C2778963024 @default.
• W3213302629 hasConcept C44249647 @default.
• W3213302629 hasConcept C68443243 @default.
• W3213302629 hasConcept C71924100 @default.
• W3213302629 hasConcept C78529466 @default.
• W3213302629 hasConcept C90924648 @default.
• W3213302629 hasConceptScore W3213302629C10515644 @default.
• W3213302629 hasConceptScore W3213302629C126322002 @default.
• W3213302629 hasConceptScore W3213302629C2777714996 @default.
• W3213302629 hasConceptScore W3213302629C2777761686 @default.
• W3213302629 hasConceptScore W3213302629C2778341716 @default.
• W3213302629 hasConceptScore W3213302629C2778963024 @default.
• W3213302629 hasConceptScore W3213302629C44249647 @default.
• W3213302629 hasConceptScore W3213302629C68443243 @default.
• W3213302629 hasConceptScore W3213302629C71924100 @default.
• W3213302629 hasConceptScore W3213302629C78529466 @default.
• W3213302629 hasConceptScore W3213302629C90924648 @default.
• W3213302629 hasLocation W32133026291 @default.
• W3213302629 hasOpenAccess W3213302629 @default.
• W3213302629 hasPrimaryLocation W32133026291 @default.
• W3213302629 hasRelatedWork W2167396905 @default.
• W3213302629 hasRelatedWork W2508592054 @default.
• W3213302629 hasRelatedWork W2659070212 @default.
• W3213302629 hasRelatedWork W2731056808 @default.
• W3213302629 hasRelatedWork W2896153255 @default.
• W3213302629 hasRelatedWork W2962831438 @default.
• W3213302629 hasRelatedWork W3087103618 @default.
• W3213302629 hasRelatedWork W3161446648 @default.
• W3213302629 hasRelatedWork W3200508748 @default.
• W3213302629 hasRelatedWork W3213302629 @default.
• W3213302629 isParatext "false" @default.
• W3213302629 isRetracted "false" @default.
• W3213302629 magId "3213302629" @default.
• W3213302629 workType "article" @default.