FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213303093> ?p ?o ?g. }

• W3213303093 abstract "Infectious dermatological diseases caused by Malassezia furfur are often chronic, recurrent, and recalcitrant. Current therapeutic options are usually tedious, repetitive, and associated with adverse effects. Alternatives that broaden the treatment options and reduce side effects for patients are needed. Antimicrobial photodynamic therapy (aPDT) is an emerging approach that is quite suitable for superficial infections. The aim of this study is to investigate the antimicrobial efficacy and effect of aPDT mediated by haematoporphyrin monomethyl ether (HMME) and aloe emodin (AE) on clinical isolates of M. furfur in vitro. The photodynamic antimicrobial efficacy of HMME and AE against M. furfur was assessed by colony forming unit (CFU) assay. The uptake of HMME and AE by M. furfur cells was investigated by fluorescence microscopy. Reactive oxygen species (ROS) probe and flow cytometry were employed to evaluate the intracellular ROS level. The effect of HMME and AE-mediated aPDT on secreted protease and lipase activity of M. furfur was also investigated. The results showed that HMME and AE in the presence of light effectively inactivated M. furfur cells in a photosensitizer (PS) concentration and light energy dose-dependent manner. AE exhibited higher antimicrobial efficacy against M. furfur than HMME under the same irradiation condition. HMME and AE-mediated aPDT disturbed the fungal cell envelop, significantly increased the intracellular ROS level, and effectively inhibited the activity of secreted protease and lipase of M. furfur cells. The results suggest that HMME and AE have potential to serve as PSs in the photodynamic treatment of dermatological diseases caused by M. furfur, but further ex vivo or in vivo experiments are needed to verify that they can meet the requirements for clinical practice." @default.
• W3213303093 created "2021-11-22" @default.
• W3213303093 creator A5016016857 @default.
• W3213303093 creator A5024917626 @default.
• W3213303093 creator A5045572616 @default.
• W3213303093 creator A5050311492 @default.
• W3213303093 creator A5055362163 @default.
• W3213303093 creator A5057286088 @default.
• W3213303093 creator A5063952694 @default.
• W3213303093 creator A5085651073 @default.
• W3213303093 date "2021-11-16" @default.
• W3213303093 modified "2023-10-14" @default.
• W3213303093 title "Antifungal Effect of Antimicrobial Photodynamic Therapy Mediated by Haematoporphyrin Monomethyl Ether and Aloe Emodin on Malassezia furfur" @default.
• W3213303093 cites W1578038757 @default.
• W3213303093 cites W1965932776 @default.
• W3213303093 cites W1975573119 @default.
• W3213303093 cites W1980326012 @default.
• W3213303093 cites W1980983289 @default.
• W3213303093 cites W1981056157 @default.
• W3213303093 cites W1990198041 @default.
• W3213303093 cites W2015545044 @default.
• W3213303093 cites W2031201987 @default.
• W3213303093 cites W2032075730 @default.
• W3213303093 cites W2054496327 @default.
• W3213303093 cites W2101381164 @default.
• W3213303093 cites W2104283742 @default.
• W3213303093 cites W2116088999 @default.
• W3213303093 cites W2116310519 @default.
• W3213303093 cites W2121117313 @default.
• W3213303093 cites W2121390784 @default.
• W3213303093 cites W2144630525 @default.
• W3213303093 cites W2145213448 @default.
• W3213303093 cites W2147563741 @default.
• W3213303093 cites W2155002081 @default.
• W3213303093 cites W2155908385 @default.
• W3213303093 cites W2163124965 @default.
• W3213303093 cites W2188671013 @default.
• W3213303093 cites W2213355316 @default.
• W3213303093 cites W2292025171 @default.
• W3213303093 cites W2408313511 @default.
• W3213303093 cites W2534577399 @default.
• W3213303093 cites W2589123068 @default.
• W3213303093 cites W2605755700 @default.
• W3213303093 cites W2606018672 @default.
• W3213303093 cites W2612589649 @default.
• W3213303093 cites W2736306625 @default.
• W3213303093 cites W2905039737 @default.
• W3213303093 cites W2954534270 @default.
• W3213303093 cites W2956123706 @default.
• W3213303093 cites W3009978682 @default.
• W3213303093 cites W3012170784 @default.
• W3213303093 cites W3026451067 @default.
• W3213303093 cites W3044308947 @default.
• W3213303093 cites W3048966006 @default.
• W3213303093 cites W3093951995 @default.
• W3213303093 cites W3110343229 @default.
• W3213303093 cites W3158757257 @default.
• W3213303093 cites W3176834066 @default.
• W3213303093 cites W906718541 @default.
• W3213303093 doi "https://doi.org/10.3389/fmicb.2021.749106" @default.
• W3213303093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34867868" @default.
• W3213303093 hasPublicationYear "2021" @default.
• W3213303093 type Work @default.
• W3213303093 sameAs 3213303093 @default.
• W3213303093 citedByCount "2" @default.
• W3213303093 countsByYear W32133030932023 @default.
• W3213303093 crossrefType "journal-article" @default.
• W3213303093 hasAuthorship W3213303093A5016016857 @default.
• W3213303093 hasAuthorship W3213303093A5024917626 @default.
• W3213303093 hasAuthorship W3213303093A5045572616 @default.
• W3213303093 hasAuthorship W3213303093A5050311492 @default.
• W3213303093 hasAuthorship W3213303093A5055362163 @default.
• W3213303093 hasAuthorship W3213303093A5057286088 @default.
• W3213303093 hasAuthorship W3213303093A5063952694 @default.
• W3213303093 hasAuthorship W3213303093A5085651073 @default.
• W3213303093 hasBestOaLocation W32133030931 @default.
• W3213303093 hasConcept C178790620 @default.
• W3213303093 hasConcept C185592680 @default.
• W3213303093 hasConcept C2777472678 @default.
• W3213303093 hasConcept C2778248515 @default.
• W3213303093 hasConcept C2781323092 @default.
• W3213303093 hasConcept C2781469039 @default.
• W3213303093 hasConcept C4937899 @default.
• W3213303093 hasConcept C55493867 @default.
• W3213303093 hasConcept C86803240 @default.
• W3213303093 hasConcept C89423630 @default.
• W3213303093 hasConcept C98274493 @default.
• W3213303093 hasConceptScore W3213303093C178790620 @default.
• W3213303093 hasConceptScore W3213303093C185592680 @default.
• W3213303093 hasConceptScore W3213303093C2777472678 @default.
• W3213303093 hasConceptScore W3213303093C2778248515 @default.
• W3213303093 hasConceptScore W3213303093C2781323092 @default.
• W3213303093 hasConceptScore W3213303093C2781469039 @default.
• W3213303093 hasConceptScore W3213303093C4937899 @default.
• W3213303093 hasConceptScore W3213303093C55493867 @default.
• W3213303093 hasConceptScore W3213303093C86803240 @default.
• W3213303093 hasConceptScore W3213303093C89423630 @default.
• W3213303093 hasConceptScore W3213303093C98274493 @default.
• W3213303093 hasFunder F4320336567 @default.
• W3213303093 hasLocation W32133030931 @default.

• next