Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213304791> ?p ?o ?g. }
- W3213304791 endingPage "112245" @default.
- W3213304791 startingPage "112245" @default.
- W3213304791 abstract "Cathepsin S (CTSS), a lysosomal protease, belongs to a family of cysteine cathepsin proteases that promote degradation of damaged proteins in the endolysosomal pathway. Aberrant CTSS expression and regulation are associated with the pathogenesis of several diseases, including lung diseases. CTSS overexpression causes a variety of pathological processes, including pulmonary fibrosis, with increased CTSS secretion and accelerated extracellular matrix remodeling. Compared to many other cysteine cathepsin family members, CTSS has unique features that it presents limited tissue expression and retains its enzymatic activity at a neutral pH, suggesting its decisive involvement in disease microenvironments. In this review, we investigated the role of CTSS in lung disease, exploring recent studies that have indicated that CTSS mediates fibrosis in unique ways, along with its structure, substrates, and distinct regulation. We also outlined examples of CTSS inhibitors in clinical and preclinical development and proposed CTSS as a potential therapeutic target for pulmonary fibrosis." @default.
- W3213304791 created "2021-11-22" @default.
- W3213304791 creator A5000644910 @default.
- W3213304791 creator A5014085183 @default.
- W3213304791 creator A5024148185 @default.
- W3213304791 creator A5024460134 @default.
- W3213304791 creator A5025050406 @default.
- W3213304791 creator A5059901009 @default.
- W3213304791 creator A5068527459 @default.
- W3213304791 creator A5072392152 @default.
- W3213304791 date "2022-01-01" @default.
- W3213304791 modified "2023-10-01" @default.
- W3213304791 title "Therapeutic potential of targeting cathepsin S in pulmonary fibrosis" @default.
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