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- W3213309739 abstract "Due to the global COVID-19 pandemic, there is a need to screen for novel compounds with antiviral activity against SARS-COV-2. Here we compared chemical composition and the in vitro anti- SARS-COV-2 activity of two different Ulva sp. crude ulvan extracts: one obtained by an HCl-based and another one by ammonium oxalate-based (AOx) extraction protocols. The composition of the crude extracts was analyzed and their antiviral activity was assessed in a cytopathic effect reduction assay using Vero E6 cells. We show that the extraction protocols have a significant impact on the chemical composition, anti- SARS-COV-2 activity, and cytotoxicity of these ulvan extracts. The ulvan extract based on the AOx protocol had a higher average molecular weight, higher charge, and 11.3-fold higher antiviral activity than HCl-based extract. Our results strongly suggest that further bioassay-guided investigation into bioactivity of compounds found in Ulva sp. ulvan extracts could lead to the discovery of novel anti-SARS-CoV-2 antivirals." @default.
- W3213309739 created "2021-11-22" @default.
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- W3213309739 date "2021-11-15" @default.
- W3213309739 modified "2023-10-05" @default.
- W3213309739 title "Fighting SARS-CoV-2 with green seaweed <i>Ulva</i> sp. extract: extraction protocol predetermines crude ulvan extract anti-SARS-CoV-2 inhibition properties in <i>in vitro</i> Vero-E6 cells assay" @default.
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- W3213309739 doi "https://doi.org/10.7717/peerj.12398" @default.
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