FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213357186> ?p ?o ?g. }

• W3213357186 abstract "Background: Available in-vitro and animal studies indicate that inflammation impacts cytochromes P450 (CYP) activity via multiple and complex transcriptional and post-transcriptional mechanisms, depending on the specific CYP isoforms and the nature of inflammation mediators. It is essential to review the current published data on the impact of inflammation on CYP activities in adults to support drug individualization based on comorbidities and diseases in clinical practice. Methods: This systematic review was conducted in PubMed through 7th January 2021 looking for articles that investigated the consequences of inflammation on CYP activities in adults. Information on the source of inflammation, victim drugs (and CYPs involved), effect of disease-drug interaction, number of subjects, and study design were extracted. Results: The search strategy identified 218 studies and case reports that met our inclusion criteria. These articles were divided into fourteen different sources of inflammation (such as infection, autoimmune diseases, cancer, therapies with immunomodulator…). The impact of inflammation on CYP activities appeared to be isoform-specific and dependent on the nature and severity of the underlying disease causing the inflammation. Some of these drug-disease interactions had a significant influence on drug pharmacokinetic parameters and on clinical management. For example, clozapine levels doubled with signs of toxicity during infections and the concentration ratio between clopidogrel's active metabolite and clopidogrel is 48-fold lower in critically ill patients. Infection and CYP3A were the most cited perpetrator of inflammation and the most studied CYP, respectively. Moreover, some data suggest that resolution of inflammation results in a return to baseline CYP activities. Conclusion: Convincing evidence shows that inflammation is a major factor to be taken into account in drug development and in clinical practice to avoid any efficacy or safety issues because inflammation modulates CYP activities and thus drug pharmacokinetics. The impact is different depending on the CYP isoform and the inflammatory disease considered. Moreover, resolution of inflammation appears to result in a normalization of CYP activity. However, some results are still equivocal and further investigations are thus needed." @default.
• W3213357186 created "2021-11-22" @default.
• W3213357186 creator A5000011411 @default.
• W3213357186 creator A5011807009 @default.
• W3213357186 creator A5020492385 @default.
• W3213357186 creator A5067282623 @default.
• W3213357186 date "2021-11-16" @default.
• W3213357186 modified "2023-10-13" @default.
• W3213357186 title "Influence of Inflammation on Cytochromes P450 Activity in Adults: A Systematic Review of the Literature" @default.
• W3213357186 cites W1034530389 @default.
• W3213357186 cites W1218506839 @default.
• W3213357186 cites W1229245056 @default.
• W3213357186 cites W1487051334 @default.
• W3213357186 cites W1510242026 @default.
• W3213357186 cites W1516841118 @default.
• W3213357186 cites W1524941586 @default.
• W3213357186 cites W1525228591 @default.
• W3213357186 cites W1530019754 @default.
• W3213357186 cites W1564161931 @default.
• W3213357186 cites W1567879611 @default.
• W3213357186 cites W1575402562 @default.
• W3213357186 cites W1593542864 @default.
• W3213357186 cites W1600994878 @default.
• W3213357186 cites W1605482820 @default.
• W3213357186 cites W1666079001 @default.
• W3213357186 cites W1750258501 @default.
• W3213357186 cites W1759188384 @default.
• W3213357186 cites W1784102749 @default.
• W3213357186 cites W1794497984 @default.
• W3213357186 cites W187320919 @default.
• W3213357186 cites W1880040018 @default.
• W3213357186 cites W1883056792 @default.
• W3213357186 cites W1943096124 @default.
• W3213357186 cites W1944492097 @default.
• W3213357186 cites W1963633532 @default.
• W3213357186 cites W1964173044 @default.
• W3213357186 cites W1964853277 @default.
• W3213357186 cites W1970017068 @default.
• W3213357186 cites W1971141423 @default.
• W3213357186 cites W1973190276 @default.
• W3213357186 cites W1973524979 @default.
• W3213357186 cites W1977069230 @default.
• W3213357186 cites W1979823763 @default.
• W3213357186 cites W1982165803 @default.
• W3213357186 cites W1982753820 @default.
• W3213357186 cites W1986830576 @default.
• W3213357186 cites W1986951768 @default.
• W3213357186 cites W1988144987 @default.
• W3213357186 cites W1990174203 @default.
• W3213357186 cites W1992475241 @default.
• W3213357186 cites W1992683547 @default.
• W3213357186 cites W1993025511 @default.
• W3213357186 cites W1997682516 @default.
• W3213357186 cites W2000037934 @default.
• W3213357186 cites W2000615749 @default.
• W3213357186 cites W2001377918 @default.
• W3213357186 cites W2003184138 @default.
• W3213357186 cites W2007149752 @default.
• W3213357186 cites W2009035069 @default.
• W3213357186 cites W2009482238 @default.
• W3213357186 cites W2010606080 @default.
• W3213357186 cites W2011520415 @default.
• W3213357186 cites W2012919964 @default.
• W3213357186 cites W2013920928 @default.
• W3213357186 cites W2015244046 @default.
• W3213357186 cites W2015541431 @default.
• W3213357186 cites W2015870178 @default.
• W3213357186 cites W2016670652 @default.
• W3213357186 cites W2017366094 @default.
• W3213357186 cites W2019962899 @default.
• W3213357186 cites W2021789263 @default.
• W3213357186 cites W2021829014 @default.
• W3213357186 cites W2022659978 @default.
• W3213357186 cites W2022729779 @default.
• W3213357186 cites W2023437376 @default.
• W3213357186 cites W2026330543 @default.
• W3213357186 cites W2026494346 @default.
• W3213357186 cites W2027374322 @default.
• W3213357186 cites W2028731404 @default.
• W3213357186 cites W2029711270 @default.
• W3213357186 cites W2032082823 @default.
• W3213357186 cites W2032584618 @default.
• W3213357186 cites W2035088108 @default.
• W3213357186 cites W2039293582 @default.
• W3213357186 cites W2040136554 @default.
• W3213357186 cites W2040571457 @default.
• W3213357186 cites W2043574684 @default.
• W3213357186 cites W2043621582 @default.
• W3213357186 cites W2043666407 @default.
• W3213357186 cites W2045184768 @default.
• W3213357186 cites W2049535135 @default.
• W3213357186 cites W2050347628 @default.
• W3213357186 cites W2051314876 @default.
• W3213357186 cites W2051771615 @default.
• W3213357186 cites W2054565825 @default.
• W3213357186 cites W2056054656 @default.
• W3213357186 cites W2057717414 @default.
• W3213357186 cites W2059707575 @default.
• W3213357186 cites W2061208588 @default.
• W3213357186 cites W2061597100 @default.

• next