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- W3213360805 abstract "Accumulating studies suggest an interaction between presbycusis (PC) and cognitive impairment, which may be explained by the cognitive-ear link to a large extent. However, the neurophysiological mechanisms underlying this link are largely unknown. Here, 51 PC patients and 51 well-matched healthy controls were recruited. We combined resting-state functional MRI and edited magnetic resonance spectroscopy to investigate changes of intra- and inter-network functional connectivity and their relationships with auditory gamma-aminobutyric acid (GABA) and glutamate (Glu) levels and cognitive impairment in PC. Our study confirmed the plastic model of cognitive-ear link at the level of the large-scale brain network, including the dysconnectivity within high-order cognitive networks and between the auditory-cognitive network and overactivation between cognitive networks dependent on hearing loss, which was closely related to the cognitive impairment of PC patients. Moreover, GABA and Glu levels in the central auditory processing were abnormal in patients with PC. Importantly, reduction of GABA-mediated inhibition plays a crucial role in a dysconnectivity between the auditory-cognitive network, which may be neurochemical underpinnings of functional remodeling of cognitive-ear link in PC. Modulation of GABA neurotransmission may enable the development of new therapeutic strategies for the cognitive impairment of PC patients. Keywords: presbycusis, cognitive impairment, cognitive-ear link, GABA, resting-state networks." @default.
- W3213360805 created "2021-11-22" @default.
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- W3213360805 date "2021-11-03" @default.
- W3213360805 modified "2023-09-30" @default.
- W3213360805 title "Dysconnectivity between auditory-cognitive network associated with auditory GABA and glutamate levels in presbycusis patients" @default.
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- W3213360805 doi "https://doi.org/10.1101/2021.10.31.466279" @default.
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