FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213367726> ?p ?o ?g. }

• W3213367726 endingPage "173" @default.
• W3213367726 startingPage "164" @default.
• W3213367726 abstract "Innovations in immuno-oncology for lymphomas have outpaced therapeutic developments in any other cancer histology. In the 1990s, rituximab, a CD20 monoclonal antibody, drastically changed treatment paradigms for B-cell non-Hodgkin lymphomas (B-NHLs). In parallel, the concept that T cells could be genetically reprogrammed and regulated to address tumor cell evasion was developed. Twenty years later, this concept has materialized-3 customized engineered CD19 chimeric antigen receptor T-cell (CART) constructs have been embraced as third-line therapies and beyond for aggressive B-NHL. Responses with CARTs are durable in 30% to 40% of patients, with consistent results in older patients, primary refractory disease, high-grade B-cell lymphoma, and patients with concurrent secondary central nervous system disease, all features historically associated with poorer outcomes. Challenges associated with the administration of CARTs include cumbersome and time-consuming manufacturing processes, toxicities, and cost, not to mention a substantial risk of relapse. Fortunately, as our understanding of how to manipulate the immune system to achieve full antitumor potential has grown, so has the rapid development of off-the-shelf immunotherapies, with CD20/CD3 bispecific antibodies standing out above all others. These agents have shown promising activity in aggressive B-NHL and have the potential to circumvent some of the challenges encountered with customized engineered products. However, toxicities remain substantial, dosing schedules intensive, and experience limited with these agents. Novel customized and off-the-shelf therapeutics as well as rational combinations of these agents are underway. Ultimately, growing experience with both customized engineered and off-the-shelf immunotherapies will provide guidance on optimal methods of delivery and sequencing." @default.
• W3213367726 created "2021-11-22" @default.
• W3213367726 creator A5000227859 @default.
• W3213367726 date "2021-12-10" @default.
• W3213367726 modified "2023-10-18" @default.
• W3213367726 title "Relapsed disease: off-the-shelf immunotherapies vs customized engineered products" @default.
• W3213367726 cites W2029915215 @default.
• W3213367726 cites W2041183804 @default.
• W3213367726 cites W2150587745 @default.
• W3213367726 cites W2179454156 @default.
• W3213367726 cites W2340435799 @default.
• W3213367726 cites W2527615464 @default.
• W3213367726 cites W2539686048 @default.
• W3213367726 cites W2598700764 @default.
• W3213367726 cites W2744261860 @default.
• W3213367726 cites W2773804840 @default.
• W3213367726 cites W2790208206 @default.
• W3213367726 cites W2892758519 @default.
• W3213367726 cites W2899044337 @default.
• W3213367726 cites W2903062212 @default.
• W3213367726 cites W2903225254 @default.
• W3213367726 cites W2909334052 @default.
• W3213367726 cites W2946573760 @default.
• W3213367726 cites W2982996777 @default.
• W3213367726 cites W2984531433 @default.
• W3213367726 cites W2984927918 @default.
• W3213367726 cites W2986196170 @default.
• W3213367726 cites W2991566266 @default.
• W3213367726 cites W2998345757 @default.
• W3213367726 cites W3024978145 @default.
• W3213367726 cites W3029455232 @default.
• W3213367726 cites W3034162969 @default.
• W3213367726 cites W3034513082 @default.
• W3213367726 cites W3037697670 @default.
• W3213367726 cites W3082855561 @default.
• W3213367726 cites W3089727781 @default.
• W3213367726 cites W3092023747 @default.
• W3213367726 cites W3094642003 @default.
• W3213367726 cites W3095414066 @default.
• W3213367726 cites W3095664938 @default.
• W3213367726 cites W3095855647 @default.
• W3213367726 cites W3096470811 @default.
• W3213367726 cites W3096548119 @default.
• W3213367726 cites W3096607082 @default.
• W3213367726 cites W3097017919 @default.
• W3213367726 cites W3097169004 @default.
• W3213367726 cites W3097467929 @default.
• W3213367726 cites W3101826014 @default.
• W3213367726 cites W3110459833 @default.
• W3213367726 cites W3121903308 @default.
• W3213367726 cites W3121917550 @default.
• W3213367726 cites W3137447968 @default.
• W3213367726 cites W3139382474 @default.
• W3213367726 doi "https://doi.org/10.1182/hematology.2021000249" @default.
• W3213367726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34889415" @default.
• W3213367726 hasPublicationYear "2021" @default.
• W3213367726 type Work @default.
• W3213367726 sameAs 3213367726 @default.
• W3213367726 citedByCount "1" @default.
• W3213367726 countsByYear W32133677262022 @default.
• W3213367726 crossrefType "journal-article" @default.
• W3213367726 hasAuthorship W3213367726A5000227859 @default.
• W3213367726 hasBestOaLocation W32133677261 @default.
• W3213367726 hasConcept C115903868 @default.
• W3213367726 hasConcept C126322002 @default.
• W3213367726 hasConcept C143998085 @default.
• W3213367726 hasConcept C147483822 @default.
• W3213367726 hasConcept C18031839 @default.
• W3213367726 hasConcept C203014093 @default.
• W3213367726 hasConcept C2777701055 @default.
• W3213367726 hasConcept C2778957590 @default.
• W3213367726 hasConcept C2779134260 @default.
• W3213367726 hasConcept C2779338263 @default.
• W3213367726 hasConcept C2780653079 @default.
• W3213367726 hasConcept C2982819384 @default.
• W3213367726 hasConcept C3875195 @default.
• W3213367726 hasConcept C41008148 @default.
• W3213367726 hasConcept C502942594 @default.
• W3213367726 hasConcept C71924100 @default.
• W3213367726 hasConcept C8891405 @default.
• W3213367726 hasConceptScore W3213367726C115903868 @default.
• W3213367726 hasConceptScore W3213367726C126322002 @default.
• W3213367726 hasConceptScore W3213367726C143998085 @default.
• W3213367726 hasConceptScore W3213367726C147483822 @default.
• W3213367726 hasConceptScore W3213367726C18031839 @default.
• W3213367726 hasConceptScore W3213367726C203014093 @default.
• W3213367726 hasConceptScore W3213367726C2777701055 @default.
• W3213367726 hasConceptScore W3213367726C2778957590 @default.
• W3213367726 hasConceptScore W3213367726C2779134260 @default.
• W3213367726 hasConceptScore W3213367726C2779338263 @default.
• W3213367726 hasConceptScore W3213367726C2780653079 @default.
• W3213367726 hasConceptScore W3213367726C2982819384 @default.
• W3213367726 hasConceptScore W3213367726C3875195 @default.
• W3213367726 hasConceptScore W3213367726C41008148 @default.
• W3213367726 hasConceptScore W3213367726C502942594 @default.
• W3213367726 hasConceptScore W3213367726C71924100 @default.
• W3213367726 hasConceptScore W3213367726C8891405 @default.
• W3213367726 hasIssue "1" @default.

• next