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• W3213374906 abstract "Dopamine input to striatum can encode reward prediction error, a critical signal for updating predictions of future rewards. However, it is unclear how this mechanism handles the need to make predictions, and provide feedback, over multiple time horizons: from seconds or less (if singing a song) to potentially hours or more (if hunting for food). Here we report that dopamine pulses in distinct striatal subregions convey reward prediction errors over distinct temporal scales. Dopamine dynamics systematically accelerated from ventral to dorsal-medial to dorsal-lateral striatum, in the tempo of their spontaneous fluctuations, their integration of prior rewards, and their discounting of future rewards. This spectrum of time scales for value computations can help achieve efficient learning and adaptive motivation for a wide range of behaviors." @default.
• W3213374906 created "2021-11-22" @default.
• W3213374906 creator A5003799076 @default.
• W3213374906 creator A5050466159 @default.
• W3213374906 creator A5068252733 @default.
• W3213374906 date "2021-11-03" @default.
• W3213374906 modified "2023-09-24" @default.
• W3213374906 title "A Spectrum of Time Horizons for Dopamine Signals" @default.
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• W3213374906 doi "https://doi.org/10.1101/2021.10.31.466705" @default.
• W3213374906 hasPublicationYear "2021" @default.
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