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- W3213378938 endingPage "1639" @default.
- W3213378938 startingPage "1639" @default.
- W3213378938 abstract "Despite advances in the treatment of cancers through surgical procedures and new pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as reflected by low survival rates. The PI3K/Akt/mTOR pathway is an important signaling mechanism that regulates the cell cycle, proliferation, apoptosis, and metabolism. Importantly, deregulation of the PI3K/Akt/mTOR pathway leading to activation is common in HCC and is hence the subject of intense investigation and the focus of current therapeutics. In this review article, we consider the role of this pathway in the pathogenesis of HCC, focusing on its downstream effectors such as glycogen synthase kinase-3 (GSK-3), cAMP-response element-binding protein (CREB), forkhead box O protein (FOXO), murine double minute 2 (MDM2), p53, and nuclear factor-κB (NF-κB), and the cellular processes of lipogenesis and autophagy. In addition, we provide an update on the current ongoing clinical development of agents targeting this pathway for HCC treatments." @default.
- W3213378938 created "2021-11-22" @default.
- W3213378938 creator A5006893730 @default.
- W3213378938 creator A5055402402 @default.
- W3213378938 creator A5061856077 @default.
- W3213378938 creator A5062418443 @default.
- W3213378938 creator A5065825690 @default.
- W3213378938 date "2021-11-08" @default.
- W3213378938 modified "2023-10-04" @default.
- W3213378938 title "Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma" @default.
- W3213378938 cites W1500729563 @default.
- W3213378938 cites W1617532721 @default.
- W3213378938 cites W190488077 @default.
- W3213378938 cites W1970637701 @default.
- W3213378938 cites W1971837077 @default.
- W3213378938 cites W1972618720 @default.
- W3213378938 cites W1973416343 @default.
- W3213378938 cites W1976777085 @default.
- W3213378938 cites W1978714931 @default.
- W3213378938 cites W1984621921 @default.
- W3213378938 cites W1985764146 @default.
- W3213378938 cites W1988836265 @default.
- W3213378938 cites W1994193851 @default.
- W3213378938 cites W1995958786 @default.
- W3213378938 cites W1997533142 @default.
- W3213378938 cites W1998203489 @default.
- W3213378938 cites W1998265194 @default.
- W3213378938 cites W2007308365 @default.
- W3213378938 cites W2009378591 @default.
- W3213378938 cites W2018992554 @default.
- W3213378938 cites W2019837162 @default.
- W3213378938 cites W2022812113 @default.
- W3213378938 cites W2027217537 @default.
- W3213378938 cites W2028415754 @default.
- W3213378938 cites W2030935520 @default.
- W3213378938 cites W2042073539 @default.
- W3213378938 cites W2043865307 @default.
- W3213378938 cites W2050253519 @default.
- W3213378938 cites W2051233997 @default.
- W3213378938 cites W2055832574 @default.
- W3213378938 cites W2067681932 @default.
- W3213378938 cites W2067751798 @default.
- W3213378938 cites W2068427129 @default.
- W3213378938 cites W2068912983 @default.
- W3213378938 cites W2070396671 @default.
- W3213378938 cites W2081167500 @default.
- W3213378938 cites W2083729029 @default.
- W3213378938 cites W2097830998 @default.
- W3213378938 cites W2099283141 @default.
- W3213378938 cites W2101428185 @default.
- W3213378938 cites W2101546320 @default.
- W3213378938 cites W2102776209 @default.
- W3213378938 cites W2108215899 @default.
- W3213378938 cites W2109985652 @default.
- W3213378938 cites W2114771939 @default.
- W3213378938 cites W2115820946 @default.
- W3213378938 cites W2121509250 @default.
- W3213378938 cites W2128607432 @default.
- W3213378938 cites W2128965737 @default.
- W3213378938 cites W2130396048 @default.
- W3213378938 cites W2137257146 @default.
- W3213378938 cites W2140397999 @default.
- W3213378938 cites W2144235090 @default.
- W3213378938 cites W2148009010 @default.
- W3213378938 cites W2151062731 @default.
- W3213378938 cites W2152433582 @default.
- W3213378938 cites W2155514044 @default.
- W3213378938 cites W2158318101 @default.
- W3213378938 cites W2161636433 @default.
- W3213378938 cites W2162242700 @default.
- W3213378938 cites W2163293418 @default.
- W3213378938 cites W2184871367 @default.
- W3213378938 cites W2196306129 @default.
- W3213378938 cites W2285208450 @default.
- W3213378938 cites W2535462468 @default.
- W3213378938 cites W2560388322 @default.
- W3213378938 cites W2560499218 @default.
- W3213378938 cites W2560657110 @default.
- W3213378938 cites W2561347874 @default.
- W3213378938 cites W2562372517 @default.
- W3213378938 cites W2606367731 @default.
- W3213378938 cites W2606513998 @default.
- W3213378938 cites W2607143962 @default.
- W3213378938 cites W2614986146 @default.
- W3213378938 cites W2734724639 @default.
- W3213378938 cites W2744982526 @default.
- W3213378938 cites W2761031851 @default.
- W3213378938 cites W2770225202 @default.
- W3213378938 cites W2772163503 @default.
- W3213378938 cites W2772927056 @default.
- W3213378938 cites W2773379569 @default.
- W3213378938 cites W2783973260 @default.
- W3213378938 cites W2785091318 @default.
- W3213378938 cites W2787358630 @default.
- W3213378938 cites W2789406733 @default.
- W3213378938 cites W2790264925 @default.
- W3213378938 cites W2794816422 @default.
- W3213378938 cites W2799933121 @default.