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- W3213462059 abstract "Metal-based compounds with excellent photo-physical properties show good photochemotherapeutic performance. But, low in-depth tissue penetration of light limits their effectivity for deeply buried tumors. Encouraged by the sonosensitizing ability of the traditional organic photosensitizers, here, we developed [email protected] as a sonosensitizer by hybridizing an organometallic Ir(III) complex (Ir1) with ultrasmall gold nanoparticles (AuNPs) for efficient tumor sonodynamic therapy (SDT) for the first time. [email protected] rapidly entered the cancer cells, produced 1O2, and catalytically oxidized NADH to NAD+ under ultrasound (US) irradiation, thus resulted in cancer cells oncosis. Because of efficient passive retention in tumors post intravenous injection, [email protected] further efficiently inhibited the growth of tumors in-vivo under US stimulation without long-term toxicity to other organs. Overall, this work presents the excellent US triggered in-vitro and in-vivo anticancer profile of the novel [email protected] It is expected to increase the scope of SDT for metal-based anticancer drugs." @default.
- W3213462059 created "2021-11-22" @default.
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- W3213462059 date "2022-04-01" @default.
- W3213462059 modified "2023-10-15" @default.
- W3213462059 title "Sonodynamic cancer therapy by novel iridium-gold nanoassemblies" @default.
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- W3213462059 doi "https://doi.org/10.1016/j.cclet.2021.11.017" @default.
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