Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213500954> ?p ?o ?g. }
- W3213500954 abstract "Acute myeloid leukemia (AML) is a malignancy of immature progenitor cells. AML differentiation therapies trigger leukemia maturation and can induce remission, but relapse is prevalent and its cellular origin is unclear. Here we describe high resolution analysis of differentiation therapy response and relapse in a mouse AML model. Triggering leukemia differentiation in this model invariably produces two phenotypically distinct mature myeloid lineages in vivo. Leukemia-derived neutrophils dominate the initial wave of leukemia differentiation but clear rapidly and do not contribute to residual disease. In contrast, a therapy-induced population of mature AML-derived eosinophil-like cells persists during remission, often in extramedullary organs. Using genetic approaches we show that restricting therapy-induced leukemia maturation to the short-lived neutrophil lineage markedly reduces relapse rates and can yield cure. These results indicate that relapse can originate from therapy-resistant mature AML cells, and suggest differentiation therapy combined with targeted eradication of mature leukemia-derived lineages may improve disease outcome." @default.
- W3213500954 created "2021-11-22" @default.
- W3213500954 creator A5003275489 @default.
- W3213500954 creator A5004454968 @default.
- W3213500954 creator A5006753387 @default.
- W3213500954 creator A5018999774 @default.
- W3213500954 creator A5021901825 @default.
- W3213500954 creator A5027828146 @default.
- W3213500954 creator A5040346731 @default.
- W3213500954 creator A5046857415 @default.
- W3213500954 creator A5050235146 @default.
- W3213500954 creator A5076549063 @default.
- W3213500954 creator A5080733134 @default.
- W3213500954 creator A5084752911 @default.
- W3213500954 date "2021-11-11" @default.
- W3213500954 modified "2023-09-27" @default.
- W3213500954 title "Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy" @default.
- W3213500954 cites W127746953 @default.
- W3213500954 cites W1955652166 @default.
- W3213500954 cites W1970990212 @default.
- W3213500954 cites W1976646654 @default.
- W3213500954 cites W1982745688 @default.
- W3213500954 cites W1995675594 @default.
- W3213500954 cites W2001970353 @default.
- W3213500954 cites W2002137621 @default.
- W3213500954 cites W2006699136 @default.
- W3213500954 cites W2008297559 @default.
- W3213500954 cites W2009016013 @default.
- W3213500954 cites W2033687970 @default.
- W3213500954 cites W2053937610 @default.
- W3213500954 cites W2070503238 @default.
- W3213500954 cites W2072910248 @default.
- W3213500954 cites W2078972833 @default.
- W3213500954 cites W2098356010 @default.
- W3213500954 cites W2129338773 @default.
- W3213500954 cites W2142760199 @default.
- W3213500954 cites W2169901678 @default.
- W3213500954 cites W2253620059 @default.
- W3213500954 cites W2325223081 @default.
- W3213500954 cites W2329310651 @default.
- W3213500954 cites W2347022381 @default.
- W3213500954 cites W2417213821 @default.
- W3213500954 cites W2520159331 @default.
- W3213500954 cites W2524336716 @default.
- W3213500954 cites W2587454956 @default.
- W3213500954 cites W2588385654 @default.
- W3213500954 cites W2605757478 @default.
- W3213500954 cites W2610075594 @default.
- W3213500954 cites W2623089849 @default.
- W3213500954 cites W2624245118 @default.
- W3213500954 cites W2738259427 @default.
- W3213500954 cites W2761903029 @default.
- W3213500954 cites W2787911840 @default.
- W3213500954 cites W2788202982 @default.
- W3213500954 cites W2803179025 @default.
- W3213500954 cites W2806682325 @default.
- W3213500954 cites W2810336146 @default.
- W3213500954 cites W2884819478 @default.
- W3213500954 cites W2887948931 @default.
- W3213500954 cites W2892247627 @default.
- W3213500954 cites W2896305389 @default.
- W3213500954 cites W2897945399 @default.
- W3213500954 cites W2899605467 @default.
- W3213500954 cites W2916458303 @default.
- W3213500954 cites W2935013408 @default.
- W3213500954 cites W2945854417 @default.
- W3213500954 cites W2957813926 @default.
- W3213500954 cites W2964893790 @default.
- W3213500954 cites W2965242241 @default.
- W3213500954 cites W3001120382 @default.
- W3213500954 cites W3049084893 @default.
- W3213500954 cites W3126592607 @default.
- W3213500954 cites W4211173018 @default.
- W3213500954 doi "https://doi.org/10.1038/s41467-021-26849-w" @default.
- W3213500954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8586014" @default.
- W3213500954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34764270" @default.
- W3213500954 hasPublicationYear "2021" @default.
- W3213500954 type Work @default.
- W3213500954 sameAs 3213500954 @default.
- W3213500954 citedByCount "4" @default.
- W3213500954 countsByYear W32135009542023 @default.
- W3213500954 crossrefType "journal-article" @default.
- W3213500954 hasAuthorship W3213500954A5003275489 @default.
- W3213500954 hasAuthorship W3213500954A5004454968 @default.
- W3213500954 hasAuthorship W3213500954A5006753387 @default.
- W3213500954 hasAuthorship W3213500954A5018999774 @default.
- W3213500954 hasAuthorship W3213500954A5021901825 @default.
- W3213500954 hasAuthorship W3213500954A5027828146 @default.
- W3213500954 hasAuthorship W3213500954A5040346731 @default.
- W3213500954 hasAuthorship W3213500954A5046857415 @default.
- W3213500954 hasAuthorship W3213500954A5050235146 @default.
- W3213500954 hasAuthorship W3213500954A5076549063 @default.
- W3213500954 hasAuthorship W3213500954A5080733134 @default.
- W3213500954 hasAuthorship W3213500954A5084752911 @default.
- W3213500954 hasBestOaLocation W32135009541 @default.
- W3213500954 hasConcept C104317684 @default.
- W3213500954 hasConcept C201750760 @default.
- W3213500954 hasConcept C203014093 @default.
- W3213500954 hasConcept C2776601000 @default.
- W3213500954 hasConcept C2776817793 @default.