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- W3213508721 abstract "The global COVID-19 pandemic has shone a light on the rates and dangers of alcohol misuse in adults and adolescents in the US and globally. Alcohol exposure during adolescence causes persistent molecular, cellular, and behavioral changes that increase the risk of alcohol use disorder (AUD) into adulthood. It is established that alcohol abuse in adulthood increases the likelihood of pain hypersensitivity and the genesis of chronic pain, and humans report drinking alcohol to relieve pain symptoms. However, the longitudinal effects of alcohol exposure on pain and the underlying CNS signaling that mediates it are understudied. Specific brain regions mediate pain effects, alcohol effects, and pain-alcohol interactions, and neural signaling in those brain regions is modulated by neuropeptides. The CNS melanocortin system is sensitive to alcohol and modulates pain sensitivity, but this system is understudied in the context of pain-alcohol interactions. In this review, we focus on the role of melanocortin signaling in brain regions sensitive to alcohol and pain, in particular the amygdala. We also discuss interactions of melanocortins with other peptide systems, including the opioid system, as potential mediators of pain-alcohol interactions. Therapeutic strategies that target the melanocortin system may mitigate the negative consequences of alcohol misuse during adolescence and/or adulthood, including effects on pain-related outcomes." @default.
- W3213508721 created "2021-11-22" @default.
- W3213508721 creator A5024162682 @default.
- W3213508721 creator A5043734937 @default.
- W3213508721 date "2021-11-04" @default.
- W3213508721 modified "2023-10-04" @default.
- W3213508721 title "The Role of Melanocortin Plasticity in Pain-Related Outcomes After Alcohol Exposure" @default.
- W3213508721 cites W131476417 @default.
- W3213508721 cites W1602243712 @default.
- W3213508721 cites W1644726454 @default.
- W3213508721 cites W1663035787 @default.
- W3213508721 cites W1747456758 @default.
- W3213508721 cites W1798179180 @default.
- W3213508721 cites W1898940440 @default.
- W3213508721 cites W1921667799 @default.
- W3213508721 cites W1951588231 @default.
- W3213508721 cites W1965504359 @default.
- W3213508721 cites W1968742682 @default.
- W3213508721 cites W1969063633 @default.
- W3213508721 cites W1970953621 @default.
- W3213508721 cites W1971951650 @default.
- W3213508721 cites W1972000079 @default.
- W3213508721 cites W1972406958 @default.
- W3213508721 cites W1972827372 @default.
- W3213508721 cites W1975327913 @default.
- W3213508721 cites W1979914335 @default.
- W3213508721 cites W1980013360 @default.
- W3213508721 cites W1981025527 @default.
- W3213508721 cites W1982615438 @default.
- W3213508721 cites W1983257841 @default.
- W3213508721 cites W1986469863 @default.
- W3213508721 cites W1986594520 @default.
- W3213508721 cites W1988650551 @default.
- W3213508721 cites W1989084391 @default.
- W3213508721 cites W1989363579 @default.
- W3213508721 cites W1990618841 @default.
- W3213508721 cites W1991116440 @default.
- W3213508721 cites W1995584991 @default.
- W3213508721 cites W1996880759 @default.
- W3213508721 cites W1997917365 @default.
- W3213508721 cites W1998206451 @default.
- W3213508721 cites W2001063140 @default.
- W3213508721 cites W2001470706 @default.
- W3213508721 cites W2002945535 @default.
- W3213508721 cites W2003175808 @default.
- W3213508721 cites W2003412110 @default.
- W3213508721 cites W2004000099 @default.
- W3213508721 cites W2006102894 @default.
- W3213508721 cites W2006206437 @default.
- W3213508721 cites W2007180342 @default.
- W3213508721 cites W2012502420 @default.
- W3213508721 cites W2013144407 @default.
- W3213508721 cites W2013885507 @default.
- W3213508721 cites W2014705712 @default.
- W3213508721 cites W2015451996 @default.
- W3213508721 cites W2016559016 @default.
- W3213508721 cites W2017228134 @default.
- W3213508721 cites W2021637956 @default.
- W3213508721 cites W2021974870 @default.
- W3213508721 cites W2023058003 @default.
- W3213508721 cites W2027839067 @default.
- W3213508721 cites W2028478130 @default.
- W3213508721 cites W2030064090 @default.
- W3213508721 cites W2036178921 @default.
- W3213508721 cites W2037447899 @default.
- W3213508721 cites W2040393764 @default.
- W3213508721 cites W2040416366 @default.
- W3213508721 cites W2040982044 @default.
- W3213508721 cites W2041997662 @default.
- W3213508721 cites W2042318783 @default.
- W3213508721 cites W2044655068 @default.
- W3213508721 cites W2047043849 @default.
- W3213508721 cites W2048236085 @default.
- W3213508721 cites W2049593710 @default.
- W3213508721 cites W2052238407 @default.
- W3213508721 cites W2053376332 @default.
- W3213508721 cites W2056955842 @default.
- W3213508721 cites W2057093903 @default.
- W3213508721 cites W2057821456 @default.
- W3213508721 cites W2057832460 @default.
- W3213508721 cites W2058441536 @default.
- W3213508721 cites W2058815815 @default.
- W3213508721 cites W2059553252 @default.
- W3213508721 cites W2063008609 @default.
- W3213508721 cites W2064342896 @default.
- W3213508721 cites W2065389660 @default.
- W3213508721 cites W2066848874 @default.
- W3213508721 cites W2067639934 @default.
- W3213508721 cites W2068287526 @default.
- W3213508721 cites W2070448790 @default.
- W3213508721 cites W2070820116 @default.
- W3213508721 cites W2071930329 @default.
- W3213508721 cites W2074303577 @default.
- W3213508721 cites W2075343941 @default.
- W3213508721 cites W2077133955 @default.
- W3213508721 cites W2077266139 @default.
- W3213508721 cites W2078489916 @default.
- W3213508721 cites W2079336703 @default.
- W3213508721 cites W2081974832 @default.
- W3213508721 cites W2082022556 @default.