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- W321352017 abstract "The bong latentperiodrequiredfortumorinduction with Simianvirus40(SV4O) inthe subcutis of hamsterscan be used to investigate whether host factor(s) participate in oncogeneels. Severaltreatmentswereappliedduringthis period, and the results were compared with those of the sametreatmentappliedin anotherseriesof experiments, homologous SV4Otumor grafting in hamsters. The results obtainedwere as follows:(a) the latent periodfor SV4O tumorinduction inthe femalewasshorterthanthat inthe male; tumordevelopmentwas delayed significantlyby oophorectomybut was little affected by orchiectomy. Tumordevelopment was markedlydelayedin animalsof both sexes by estrone given at birth but was accelerated by testosteronegiven in the aduftmale; (b) by each of these hormonal modifications, growth of transplanted SV4Otumors was influenced in a different way from that of tumorinduction; (C)immunosuppressive treatments,such as thymectomy,administration of antilymphocyte sera, cycbophosphamide, or cortisoneacetatedelayedandde creasedtumordevelopmentwhen appliedin the latent period, and the degree or pattern of this effect varied from one procedure to another,dependingonthe sexandage oftheanimals;(d) Incontrast,tumorgrowthwasmarkedly acceleratedin thymectomized or cortisone-treated hosts irrespective of sex. The differentand almostreverseeffect of the same procedurein the two phasesof tumorigenesis may mdi catetwodiscriminating mechanisms operatinginthe host duringthesephases.Thisdifferenteffectmaybe dueto virtual absence of any “mature†neoplastic cell in the latentperiod,exceptfor a few weeksbeforethe appear anceof a palpabletumor.Theseresultssuggestthatthe longperiodof latencymay be spentto completeSV4Oinducedneoplasticconversionof cells, receivingsome helpby hostfactors." @default.
- W321352017 created "2016-06-24" @default.
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- W321352017 date "1978-01-01" @default.
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- W321352017 title "SuppressiveEffectson SimianVirus40-inducedOncogenesisof Several Immunosuppressive Agentsand HormonalModificationsAppliedduring the Latent Period1" @default.
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