Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213544832> ?p ?o ?g. }
- W3213544832 abstract "The blood brain barrier (BBB) is an obstacle for the delivery of potential molecular therapies for neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). Although there has been a proliferation of potential disease modifying therapies for these progressive conditions, strategies to deliver these large agents remain limited. High intensity MRI guided focused ultrasound has already been FDA approved to lesion brain targets to treat movement disorders, while lower intensity pulsed ultrasound coupled with microbubbles commonly used as contrast agents can create transient safe opening of the BBB. Pre-clinical studies have successfully delivered growth factors, antibodies, genes, viral vectors, and nanoparticles in rodent models of AD and PD. Recent small clinical trials support the safety and feasibility of this strategy in these vulnerable patients. Further study is needed to establish safety as MRI guided BBB opening is used to enhance the delivery of newly developed molecular therapies." @default.
- W3213544832 created "2021-11-22" @default.
- W3213544832 creator A5044237308 @default.
- W3213544832 creator A5089832995 @default.
- W3213544832 date "2021-11-04" @default.
- W3213544832 modified "2023-10-13" @default.
- W3213544832 title "Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases" @default.
- W3213544832 cites W133175338 @default.
- W3213544832 cites W1494864007 @default.
- W3213544832 cites W166900241 @default.
- W3213544832 cites W1970683344 @default.
- W3213544832 cites W1994462973 @default.
- W3213544832 cites W2001829400 @default.
- W3213544832 cites W2002998413 @default.
- W3213544832 cites W2003736464 @default.
- W3213544832 cites W2008871739 @default.
- W3213544832 cites W2040042139 @default.
- W3213544832 cites W2040789205 @default.
- W3213544832 cites W2042895504 @default.
- W3213544832 cites W2054714985 @default.
- W3213544832 cites W2062620218 @default.
- W3213544832 cites W2067444098 @default.
- W3213544832 cites W2078602675 @default.
- W3213544832 cites W2091723502 @default.
- W3213544832 cites W2092920458 @default.
- W3213544832 cites W2094514360 @default.
- W3213544832 cites W2098741244 @default.
- W3213544832 cites W2104607370 @default.
- W3213544832 cites W2108277337 @default.
- W3213544832 cites W2109794373 @default.
- W3213544832 cites W2111348099 @default.
- W3213544832 cites W2131358222 @default.
- W3213544832 cites W2180223963 @default.
- W3213544832 cites W2400311982 @default.
- W3213544832 cites W2402661655 @default.
- W3213544832 cites W2415670156 @default.
- W3213544832 cites W2510806376 @default.
- W3213544832 cites W2564088374 @default.
- W3213544832 cites W2614291262 @default.
- W3213544832 cites W2724650382 @default.
- W3213544832 cites W2735438407 @default.
- W3213544832 cites W2754634131 @default.
- W3213544832 cites W2790961340 @default.
- W3213544832 cites W2792189823 @default.
- W3213544832 cites W2807207060 @default.
- W3213544832 cites W2830135676 @default.
- W3213544832 cites W2897068047 @default.
- W3213544832 cites W2921121152 @default.
- W3213544832 cites W2931561204 @default.
- W3213544832 cites W2936990364 @default.
- W3213544832 cites W2959296638 @default.
- W3213544832 cites W2970727786 @default.
- W3213544832 cites W2976433890 @default.
- W3213544832 cites W2994735642 @default.
- W3213544832 cites W3015813913 @default.
- W3213544832 cites W3025813656 @default.
- W3213544832 cites W3036913958 @default.
- W3213544832 cites W3090766726 @default.
- W3213544832 cites W3092195828 @default.
- W3213544832 cites W3110785280 @default.
- W3213544832 cites W3111007101 @default.
- W3213544832 cites W3127037572 @default.
- W3213544832 cites W3142848788 @default.
- W3213544832 cites W3146410983 @default.
- W3213544832 cites W3160428681 @default.
- W3213544832 cites W3164345316 @default.
- W3213544832 cites W3174260172 @default.
- W3213544832 cites W3181899489 @default.
- W3213544832 cites W4236697 @default.
- W3213544832 doi "https://doi.org/10.3389/fneur.2021.749047" @default.
- W3213544832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8599441" @default.
- W3213544832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34803886" @default.
- W3213544832 hasPublicationYear "2021" @default.
- W3213544832 type Work @default.
- W3213544832 sameAs 3213544832 @default.
- W3213544832 citedByCount "14" @default.
- W3213544832 countsByYear W32135448322022 @default.
- W3213544832 countsByYear W32135448322023 @default.
- W3213544832 crossrefType "journal-article" @default.
- W3213544832 hasAuthorship W3213544832A5044237308 @default.
- W3213544832 hasAuthorship W3213544832A5089832995 @default.
- W3213544832 hasBestOaLocation W32135448321 @default.
- W3213544832 hasConcept C126322002 @default.
- W3213544832 hasConcept C126838900 @default.
- W3213544832 hasConcept C142724271 @default.
- W3213544832 hasConcept C143753070 @default.
- W3213544832 hasConcept C15744967 @default.
- W3213544832 hasConcept C169760540 @default.
- W3213544832 hasConcept C203014093 @default.
- W3213544832 hasConcept C2778402981 @default.
- W3213544832 hasConcept C2779134260 @default.
- W3213544832 hasConcept C2780596555 @default.
- W3213544832 hasConcept C2780640218 @default.
- W3213544832 hasConcept C2985948822 @default.
- W3213544832 hasConcept C529278444 @default.
- W3213544832 hasConcept C535046627 @default.
- W3213544832 hasConcept C64012434 @default.
- W3213544832 hasConcept C71924100 @default.
- W3213544832 hasConceptScore W3213544832C126322002 @default.
- W3213544832 hasConceptScore W3213544832C126838900 @default.