Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213549985> ?p ?o ?g. }
- W3213549985 abstract "Understanding viral rebound in pediatric HIV-1 infection may inform the development of alternatives to lifelong antiretroviral therapy (ART) to achieve viral remission. We thus investigated viral rebound after analytical treatment interruption (ATI) in 10 infant macaques orally infected with SHIV.C.CH505 and treated with long-term ART. Rebound viremia was detected within 7 to 35 days of ATI in 9 of 10 animals, with posttreatment control of viremia seen in 5 of 5 Mamu-A*01+ macaques. Single-genome sequencing revealed that initial rebound virus was similar to viral DNA present in CD4+ T cells from blood, rectum, and lymph nodes before ATI. We assessed the earliest sites of viral reactivation immediately following ATI using ImmunoPET imaging. The largest increase in signal that preceded detectable viral RNA in plasma was found in the gastrointestinal (GI) tract, a site with relatively high SHIV RNA/DNA ratios in CD4+ T cells before ATI. Thus, the GI tract may be an initial source of rebound virus, but as ATI progresses, viral reactivation in other tissues likely contributes to the composition of plasma virus. Our study provides potentially novel insight into the features of viral rebound in pediatric infection and highlights the application of a noninvasive technique to monitor areas of HIV-1 expression in children." @default.
- W3213549985 created "2021-11-22" @default.
- W3213549985 creator A5003631541 @default.
- W3213549985 creator A5007208452 @default.
- W3213549985 creator A5009267693 @default.
- W3213549985 creator A5010618682 @default.
- W3213549985 creator A5014091726 @default.
- W3213549985 creator A5014869075 @default.
- W3213549985 creator A5020621663 @default.
- W3213549985 creator A5021955501 @default.
- W3213549985 creator A5023829607 @default.
- W3213549985 creator A5027138031 @default.
- W3213549985 creator A5028122601 @default.
- W3213549985 creator A5028955260 @default.
- W3213549985 creator A5036848675 @default.
- W3213549985 creator A5040331142 @default.
- W3213549985 creator A5044021380 @default.
- W3213549985 creator A5047594920 @default.
- W3213549985 creator A5047833207 @default.
- W3213549985 creator A5051438853 @default.
- W3213549985 creator A5056778092 @default.
- W3213549985 creator A5075577675 @default.
- W3213549985 creator A5086828730 @default.
- W3213549985 creator A5087170372 @default.
- W3213549985 date "2021-12-08" @default.
- W3213549985 modified "2023-09-25" @default.
- W3213549985 title "Dynamics and origin of rebound viremia in SHIV-infected infant macaques following interruption of long-term ART" @default.
- W3213549985 cites W1978863320 @default.
- W3213549985 cites W1987979462 @default.
- W3213549985 cites W2025373690 @default.
- W3213549985 cites W2036468349 @default.
- W3213549985 cites W2041559190 @default.
- W3213549985 cites W2045361762 @default.
- W3213549985 cites W2046159404 @default.
- W3213549985 cites W2113236498 @default.
- W3213549985 cites W2126515754 @default.
- W3213549985 cites W2130560337 @default.
- W3213549985 cites W2135390958 @default.
- W3213549985 cites W2144467667 @default.
- W3213549985 cites W2149531726 @default.
- W3213549985 cites W2151758275 @default.
- W3213549985 cites W2152207030 @default.
- W3213549985 cites W2163515030 @default.
- W3213549985 cites W2168795464 @default.
- W3213549985 cites W2194273732 @default.
- W3213549985 cites W2264411206 @default.
- W3213549985 cites W2284414405 @default.
- W3213549985 cites W2298006045 @default.
- W3213549985 cites W2515870255 @default.
- W3213549985 cites W2522854796 @default.
- W3213549985 cites W2557191642 @default.
- W3213549985 cites W2608733788 @default.
- W3213549985 cites W2611282009 @default.
- W3213549985 cites W2762486448 @default.
- W3213549985 cites W2767962609 @default.
- W3213549985 cites W2772928192 @default.
- W3213549985 cites W2836819686 @default.
- W3213549985 cites W2886939453 @default.
- W3213549985 cites W2914326997 @default.
- W3213549985 cites W2949650899 @default.
- W3213549985 cites W2950744231 @default.
- W3213549985 cites W2956334145 @default.
- W3213549985 cites W2970368853 @default.
- W3213549985 cites W2995968083 @default.
- W3213549985 cites W2999054912 @default.
- W3213549985 cites W3093564455 @default.
- W3213549985 cites W3094041259 @default.
- W3213549985 cites W3097740685 @default.
- W3213549985 cites W3135456565 @default.
- W3213549985 cites W4237040044 @default.
- W3213549985 doi "https://doi.org/10.1172/jci.insight.152526" @default.
- W3213549985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34699383" @default.
- W3213549985 hasPublicationYear "2021" @default.
- W3213549985 type Work @default.
- W3213549985 sameAs 3213549985 @default.
- W3213549985 citedByCount "4" @default.
- W3213549985 countsByYear W32135499852022 @default.
- W3213549985 countsByYear W32135499852023 @default.
- W3213549985 crossrefType "journal-article" @default.
- W3213549985 hasAuthorship W3213549985A5003631541 @default.
- W3213549985 hasAuthorship W3213549985A5007208452 @default.
- W3213549985 hasAuthorship W3213549985A5009267693 @default.
- W3213549985 hasAuthorship W3213549985A5010618682 @default.
- W3213549985 hasAuthorship W3213549985A5014091726 @default.
- W3213549985 hasAuthorship W3213549985A5014869075 @default.
- W3213549985 hasAuthorship W3213549985A5020621663 @default.
- W3213549985 hasAuthorship W3213549985A5021955501 @default.
- W3213549985 hasAuthorship W3213549985A5023829607 @default.
- W3213549985 hasAuthorship W3213549985A5027138031 @default.
- W3213549985 hasAuthorship W3213549985A5028122601 @default.
- W3213549985 hasAuthorship W3213549985A5028955260 @default.
- W3213549985 hasAuthorship W3213549985A5036848675 @default.
- W3213549985 hasAuthorship W3213549985A5040331142 @default.
- W3213549985 hasAuthorship W3213549985A5044021380 @default.
- W3213549985 hasAuthorship W3213549985A5047594920 @default.
- W3213549985 hasAuthorship W3213549985A5047833207 @default.
- W3213549985 hasAuthorship W3213549985A5051438853 @default.
- W3213549985 hasAuthorship W3213549985A5056778092 @default.
- W3213549985 hasAuthorship W3213549985A5075577675 @default.
- W3213549985 hasAuthorship W3213549985A5086828730 @default.