FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213560367> ?p ?o ?g. }

• W3213560367 endingPage "3109" @default.
• W3213560367 startingPage "3109" @default.
• W3213560367 abstract "Mild hypoglycemia is common in clinical practice. Severe hypoglycemia results in heat shock protein and associate co-chaperone changes. Whether mild prolonged hypoglycemia elicits a similar response with inflammatory and oxidative-stress responses compared with a severe hypoglycemic event is unclear; therefore, this pilot exploratory study was undertaken. We performed a case-control induced hypoglycemia clamp study, maintaining blood glucose at 2.8 mmol/L (50 mg/dL) for 1 h in 17 subjects (T2D (n = 10); controls (n = 7)). Blood sampling was performed at baseline, hypoglycemia, and 24 h; slow off-rate modified aptamer (SOMA)-scan plasma protein analysis of HSP-related proteins, inflammatory stress markers, and oxidative stress markers was performed. In total, 16 HSPs were analyzed. At baseline, TLR4:MD-2 complex was elevated (p = 0.01), whilst HSPA8 was lower (p < 0.05) in T2D. At hypoglycemia, UBE2N, STIP1, and UBE2L3 increased (all p < 0.05), whilst TLR4:MD-2 and HSPA8 decreased (p < 0.05) in T2D versus baseline. In follow-up after hypoglycemia, HSPs normalized to baseline by 24 h, except UBE2L3 (p < 0.05), which was decreased in controls versus baseline. Correlation of altered inflammatory markers with HSPs revealed the following: at baseline, TLR4:MD-2 correlated with CXCL10 (p < 0.01) and SIGLEC1 (p < 0.05) in controls; HSPA8 negatively correlated with IL5 (p < 0.05) in T2D. A negative correlation between urinary isoprostane 8-iso PGF2α, a marker of oxidative stress, and HSPA1A was seen at 24 h in T2D only (p < 0.05). In conclusion, the HSP changes seen for mild prolonged hypoglycemia were similar to those previously reported for a severe event. However, mild prolonged hypoglycemia appeared to elicit an increased inflammatory response that was associated with heat shock and related proteins." @default.
• W3213560367 created "2021-11-22" @default.
• W3213560367 creator A5006910868 @default.
• W3213560367 creator A5023255400 @default.
• W3213560367 creator A5062170233 @default.
• W3213560367 creator A5064495299 @default.
• W3213560367 creator A5066169402 @default.
• W3213560367 creator A5072249083 @default.
• W3213560367 date "2021-11-10" @default.
• W3213560367 modified "2023-10-03" @default.
• W3213560367 title "Heat Shock-Related Protein Responses and Inflammatory Protein Changes Are Associated with Mild Prolonged Hypoglycemia" @default.
• W3213560367 cites W1595575404 @default.
• W3213560367 cites W1976041483 @default.
• W3213560367 cites W1976333070 @default.
• W3213560367 cites W1976531401 @default.
• W3213560367 cites W1982721738 @default.
• W3213560367 cites W1992489519 @default.
• W3213560367 cites W1999804954 @default.
• W3213560367 cites W2003965937 @default.
• W3213560367 cites W2006333520 @default.
• W3213560367 cites W2036767516 @default.
• W3213560367 cites W2047812715 @default.
• W3213560367 cites W2049287094 @default.
• W3213560367 cites W2055959752 @default.
• W3213560367 cites W2064985419 @default.
• W3213560367 cites W2067747345 @default.
• W3213560367 cites W2068105302 @default.
• W3213560367 cites W2073938056 @default.
• W3213560367 cites W2089400513 @default.
• W3213560367 cites W2116486723 @default.
• W3213560367 cites W2120511656 @default.
• W3213560367 cites W2126798009 @default.
• W3213560367 cites W2138238729 @default.
• W3213560367 cites W2142137984 @default.
• W3213560367 cites W2145025818 @default.
• W3213560367 cites W2146512944 @default.
• W3213560367 cites W2149411404 @default.
• W3213560367 cites W2411414038 @default.
• W3213560367 cites W2465534016 @default.
• W3213560367 cites W2531309672 @default.
• W3213560367 cites W2566116513 @default.
• W3213560367 cites W2585808900 @default.
• W3213560367 cites W2765766036 @default.
• W3213560367 cites W2767726506 @default.
• W3213560367 cites W2801375217 @default.
• W3213560367 cites W2802499980 @default.
• W3213560367 cites W2889115887 @default.
• W3213560367 cites W2898641344 @default.
• W3213560367 cites W2899009117 @default.
• W3213560367 cites W2904722408 @default.
• W3213560367 cites W2969570232 @default.
• W3213560367 cites W3004803684 @default.
• W3213560367 cites W3006168985 @default.
• W3213560367 cites W3009739189 @default.
• W3213560367 cites W3010856774 @default.
• W3213560367 cites W3034078364 @default.
• W3213560367 cites W3035327196 @default.
• W3213560367 cites W3091779415 @default.
• W3213560367 cites W3153906485 @default.
• W3213560367 cites W3194403836 @default.
• W3213560367 cites W4313366006 @default.
• W3213560367 doi "https://doi.org/10.3390/cells10113109" @default.
• W3213560367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8618421" @default.
• W3213560367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34831332" @default.
• W3213560367 hasPublicationYear "2021" @default.
• W3213560367 type Work @default.
• W3213560367 sameAs 3213560367 @default.
• W3213560367 citedByCount "4" @default.
• W3213560367 countsByYear W32135603672023 @default.
• W3213560367 crossrefType "journal-article" @default.
• W3213560367 hasAuthorship W3213560367A5006910868 @default.
• W3213560367 hasAuthorship W3213560367A5023255400 @default.
• W3213560367 hasAuthorship W3213560367A5062170233 @default.
• W3213560367 hasAuthorship W3213560367A5064495299 @default.
• W3213560367 hasAuthorship W3213560367A5066169402 @default.
• W3213560367 hasAuthorship W3213560367A5072249083 @default.
• W3213560367 hasBestOaLocation W32135603671 @default.
• W3213560367 hasConcept C104317684 @default.
• W3213560367 hasConcept C126322002 @default.
• W3213560367 hasConcept C134018914 @default.
• W3213560367 hasConcept C205260736 @default.
• W3213560367 hasConcept C2776151105 @default.
• W3213560367 hasConcept C2779306644 @default.
• W3213560367 hasConcept C2780668416 @default.
• W3213560367 hasConcept C55493867 @default.
• W3213560367 hasConcept C68991219 @default.
• W3213560367 hasConcept C71924100 @default.
• W3213560367 hasConcept C86803240 @default.
• W3213560367 hasConceptScore W3213560367C104317684 @default.
• W3213560367 hasConceptScore W3213560367C126322002 @default.
• W3213560367 hasConceptScore W3213560367C134018914 @default.
• W3213560367 hasConceptScore W3213560367C205260736 @default.
• W3213560367 hasConceptScore W3213560367C2776151105 @default.
• W3213560367 hasConceptScore W3213560367C2779306644 @default.
• W3213560367 hasConceptScore W3213560367C2780668416 @default.
• W3213560367 hasConceptScore W3213560367C55493867 @default.
• W3213560367 hasConceptScore W3213560367C68991219 @default.
• W3213560367 hasConceptScore W3213560367C71924100 @default.

• next