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- W3213567165 abstract "Phytochemicals have recently received a lot of recognition for their pharmacological activities such as anticancer, chemopreventive, and cardioprotective properties. In traditional Indian and Chinese medicine, parts of lotus (Nelumbo nucifera) such as lotus seeds, fruits, stamens, and leaves are used for treating various diseases. Neferine is a bisbenzylisoquinoline alkaloid, a major component from the seed embryos of N. nucifera. Neferine is effective in the treatment of high fevers and hyposomnia, as well as arrhythmia, platelet aggregation, occlusion, and obesity. Neferine has been found to have a variety of therapeutic effects such as anti-inflammatory, anti-oxidant, anti-hypertensive, anti-arrhythmic, anti-platelet, anti-thrombotic, anti-amnesic, and negative inotropic. Neferine also exhibited anti-anxiety effects, anti-cancerous, and chemosensitize to other anticancer drugs like doxorubicin, cisplatin, and taxol. Induction of apoptosis, autophagy, and cell cycle arrest are the key pathways that underlying the anticancer activity of neferine. Therefore, the present review summarizes the neferine biosynthesis, pharmacokinetics, and its effects in myocardium, cancer, chemosensitizing to cancer drug, central nervous system, diabetes, inflammation, and kidney diseases. PRACTICAL APPLICATIONS: Natural phytochemical is gaining medicinal importance for a variety of diseases like including cancer, neurodegenerative disorder, diabetes, and inflammation. Alkaloids and flavonoids, which are abundantly present in Nelumbo nucifera have many therapeutic applications. Neferine, a bisbenzylisoquinoline alkaloid from N. nucifera has many pharmacological properties. This present review was an attempt to compile an updated pharmacological action of neferine in different disease models in vitro and in vivo, as well as to summarize all the collective evidence on the therapeutic potential of neferine." @default.
- W3213567165 created "2021-11-22" @default.
- W3213567165 creator A5025617602 @default.
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- W3213567165 creator A5043459440 @default.
- W3213567165 creator A5056489118 @default.
- W3213567165 creator A5066663819 @default.
- W3213567165 date "2021-11-14" @default.
- W3213567165 modified "2023-10-12" @default.
- W3213567165 title "An updated review on pharmacological properties of neferine—A bisbenzylisoquinoline alkaloid from <i>Nelumbo nucifera</i>" @default.
- W3213567165 cites W1697086437 @default.
- W3213567165 cites W1847627398 @default.
- W3213567165 cites W1914349466 @default.
- W3213567165 cites W1973151428 @default.
- W3213567165 cites W1974904794 @default.
- W3213567165 cites W1978919526 @default.
- W3213567165 cites W1979157547 @default.
- W3213567165 cites W1979378419 @default.
- W3213567165 cites W1985184412 @default.
- W3213567165 cites W1985321236 @default.
- W3213567165 cites W1991830196 @default.
- W3213567165 cites W1994051836 @default.
- W3213567165 cites W1996175714 @default.
- W3213567165 cites W1998671183 @default.
- W3213567165 cites W1998748634 @default.
- W3213567165 cites W2001800037 @default.
- W3213567165 cites W2004249391 @default.
- W3213567165 cites W2005331291 @default.
- W3213567165 cites W2007865382 @default.
- W3213567165 cites W2013226691 @default.
- W3213567165 cites W2021273457 @default.
- W3213567165 cites W2025236490 @default.
- W3213567165 cites W2026994377 @default.
- W3213567165 cites W2028572100 @default.
- W3213567165 cites W2037710416 @default.
- W3213567165 cites W2038735800 @default.
- W3213567165 cites W2038771381 @default.
- W3213567165 cites W2040701698 @default.
- W3213567165 cites W2040981870 @default.
- W3213567165 cites W2042769296 @default.
- W3213567165 cites W2043616151 @default.
- W3213567165 cites W2051032848 @default.
- W3213567165 cites W2051339264 @default.
- W3213567165 cites W2054182657 @default.
- W3213567165 cites W2061447269 @default.
- W3213567165 cites W2063035156 @default.
- W3213567165 cites W2067342321 @default.
- W3213567165 cites W2068346686 @default.
- W3213567165 cites W2082625505 @default.
- W3213567165 cites W2083477822 @default.
- W3213567165 cites W2083481472 @default.
- W3213567165 cites W2127800696 @default.
- W3213567165 cites W2132619854 @default.
- W3213567165 cites W2135927648 @default.
- W3213567165 cites W2147166114 @default.
- W3213567165 cites W2164405341 @default.
- W3213567165 cites W2164441165 @default.
- W3213567165 cites W2218290242 @default.
- W3213567165 cites W2269205783 @default.
- W3213567165 cites W2322351747 @default.
- W3213567165 cites W2414108046 @default.
- W3213567165 cites W2509971113 @default.
- W3213567165 cites W2585150725 @default.
- W3213567165 cites W2588855252 @default.
- W3213567165 cites W2618798752 @default.
- W3213567165 cites W2731469669 @default.
- W3213567165 cites W2739172015 @default.
- W3213567165 cites W2755290410 @default.
- W3213567165 cites W2791846263 @default.
- W3213567165 cites W2898419528 @default.
- W3213567165 cites W2899887857 @default.
- W3213567165 cites W2902743750 @default.
- W3213567165 cites W2903549397 @default.
- W3213567165 cites W2945620438 @default.
- W3213567165 cites W2949825325 @default.
- W3213567165 cites W2951098074 @default.
- W3213567165 cites W2955205791 @default.
- W3213567165 cites W2964687064 @default.
- W3213567165 cites W2980912034 @default.
- W3213567165 cites W2995212439 @default.
- W3213567165 cites W2995491317 @default.
- W3213567165 cites W2997952322 @default.
- W3213567165 cites W3008447206 @default.
- W3213567165 cites W3013010543 @default.
- W3213567165 cites W3021424133 @default.
- W3213567165 cites W3026001663 @default.
- W3213567165 cites W3029814337 @default.
- W3213567165 cites W3030253196 @default.
- W3213567165 cites W3032813646 @default.
- W3213567165 cites W3038775812 @default.
- W3213567165 cites W3120366548 @default.
- W3213567165 cites W3162314501 @default.
- W3213567165 cites W3186767777 @default.
- W3213567165 cites W3190612834 @default.
- W3213567165 cites W4234381551 @default.
- W3213567165 cites W4255947301 @default.
- W3213567165 cites W2104155767 @default.
- W3213567165 doi "https://doi.org/10.1111/jfbc.13986" @default.
- W3213567165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34779018" @default.
- W3213567165 hasPublicationYear "2021" @default.