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• W3213633504 endingPage "3204" @default.
• W3213633504 startingPage "3204" @default.
• W3213633504 abstract "Increased metabolism that occurs during pregnancy can result in oxidative stress which is harmful to cells and, consequently, for the proper functioning of the whole organism. Plasma and recently also saliva are important resources for evaluating physiological and pathological conditions in animals. The study aimed to investigate the influence of the metabolic state on the effectiveness of the antioxidant profile of plasma and saliva during the pregnancy of cows. Seventy-six healthy pregnant and twelve non-pregnant control cows were included in the study. Blood and saliva samples were collected each month of the pregnancy course. Examined body fluids were used to evaluate both the total antioxidant capacity (TAC) and the oxidative parameters related to protein and lipid peroxidative processes. TAC, the content of hydroperoxides, and SH groups were determined spectrophotometrically while formylokinurenine and bityrosine contents were measured spectrofluorimetrically. The results showed dynamic changes depending on the period of pregnancy course. The highest antioxidant activity in plasma was mostly noted in early pregnancy and advanced pregnant cows. All tested parameters except SH groups expressed higher values in saliva compared to plasma. Obtained results reveal that the increase in oxidative intensity induced appropriate answers of cells reflected in the increase in antioxidative activity of the organism. Moreover, some examined parameters can indicate the intensity of oxidative stress and therefore could be used in a panel of markers of the physiological course of pregnancy. However, with regards to antioxidant/oxidative parameters, saliva reflects the content of plasma only in part, due to the local metabolism of the salivary gland. Further studies are necessary to establish physiological ranges of antioxidative/oxidative profiles in cows and to define the usefulness of saliva as biological material in oxidative stress diagnostics." @default.
• W3213633504 created "2021-11-22" @default.
• W3213633504 creator A5019826178 @default.
• W3213633504 creator A5037386496 @default.
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• W3213633504 date "2021-11-10" @default.
• W3213633504 modified "2023-10-03" @default.
• W3213633504 title "Antioxidative and Oxidative Profiles in Plasma and Saliva in Dairy Cows during Pregnancy" @default.
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• W3213633504 doi "https://doi.org/10.3390/ani11113204" @default.
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• W3213633504 hasPublicationYear "2021" @default.
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