Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213641906> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3213641906 abstract "Human populations, especially European, are polymorphic in the RHD gene. A significant fraction of their members carry no copy of the coding section of RHD gene, which results in their Rh-negative blood type. Theoretically, this polymorphism should be unstable. Carriers of the less frequent allele are penalized by reduced fertility because of the immunization of RhD-negative mothers by their RhD-positive babies, which results in hemolytic disease of the fetus and newborn in their subsequent progeny. For about 90 years, some form of balancing selection has been suspected to sustain this polymorphism. Several recent studies showed that the RhD-positive heterozygotes express higher viability than both types of homozygotes. However, the genotype of subjects in these studies was estimated only by indirect methods. Here we compared the physical and mental health of 178 women and 86 men who were directly tested for their RHD genotype. The results showed that RhD-positive homozygotic women had worse and RhD-positive homozygotic men better physical health than RhD-negative homozygotes; the difference between RhD-negative homozygotes and heterozygotes was not significant. Our results confirmed that health of RhD-positive heterozygotes and homozygotes differ. Therefore, any result of the comparison of subjects with RhD-positive and RhD-negative phenotype depends on the heterozygote-to-homozygote ratio in the RhD-positive sample. It is, therefore, crucial to analyze the effects of RHD-genotypes, not phenotypes in future studies." @default.
- W3213641906 created "2021-11-22" @default.
- W3213641906 creator A5026263661 @default.
- W3213641906 creator A5040314046 @default.
- W3213641906 creator A5053035629 @default.
- W3213641906 creator A5060783940 @default.
- W3213641906 creator A5068803166 @default.
- W3213641906 creator A5089556889 @default.
- W3213641906 date "2021-11-09" @default.
- W3213641906 modified "2023-09-27" @default.
- W3213641906 title "The importance of being heterozygote: effects of RHD-genotype-sex interaction on the physical and mental health of a non-clinical population" @default.
- W3213641906 cites W1499849192 @default.
- W3213641906 cites W1602176128 @default.
- W3213641906 cites W1981726677 @default.
- W3213641906 cites W1996349809 @default.
- W3213641906 cites W2047819730 @default.
- W3213641906 cites W2054886733 @default.
- W3213641906 cites W2061897827 @default.
- W3213641906 cites W2084594144 @default.
- W3213641906 cites W2097659338 @default.
- W3213641906 cites W2109478095 @default.
- W3213641906 cites W2110595879 @default.
- W3213641906 cites W2115595626 @default.
- W3213641906 cites W2179299871 @default.
- W3213641906 cites W2260438099 @default.
- W3213641906 cites W2332016763 @default.
- W3213641906 cites W2587472464 @default.
- W3213641906 cites W3043502620 @default.
- W3213641906 cites W3107348958 @default.
- W3213641906 cites W4238867031 @default.
- W3213641906 doi "https://doi.org/10.1038/s41598-021-00977-1" @default.
- W3213641906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8578618" @default.
- W3213641906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34753960" @default.
- W3213641906 hasPublicationYear "2021" @default.
- W3213641906 type Work @default.
- W3213641906 sameAs 3213641906 @default.
- W3213641906 citedByCount "1" @default.
- W3213641906 countsByYear W32136419062023 @default.
- W3213641906 crossrefType "journal-article" @default.
- W3213641906 hasAuthorship W3213641906A5026263661 @default.
- W3213641906 hasAuthorship W3213641906A5040314046 @default.
- W3213641906 hasAuthorship W3213641906A5053035629 @default.
- W3213641906 hasAuthorship W3213641906A5060783940 @default.
- W3213641906 hasAuthorship W3213641906A5068803166 @default.
- W3213641906 hasAuthorship W3213641906A5089556889 @default.
- W3213641906 hasBestOaLocation W32136419061 @default.
- W3213641906 hasConcept C104317684 @default.
- W3213641906 hasConcept C121857725 @default.
- W3213641906 hasConcept C135763542 @default.
- W3213641906 hasConcept C149737253 @default.
- W3213641906 hasConcept C153471976 @default.
- W3213641906 hasConcept C159654299 @default.
- W3213641906 hasConcept C180754005 @default.
- W3213641906 hasConcept C2908647359 @default.
- W3213641906 hasConcept C54355233 @default.
- W3213641906 hasConcept C71924100 @default.
- W3213641906 hasConcept C86803240 @default.
- W3213641906 hasConcept C99454951 @default.
- W3213641906 hasConceptScore W3213641906C104317684 @default.
- W3213641906 hasConceptScore W3213641906C121857725 @default.
- W3213641906 hasConceptScore W3213641906C135763542 @default.
- W3213641906 hasConceptScore W3213641906C149737253 @default.
- W3213641906 hasConceptScore W3213641906C153471976 @default.
- W3213641906 hasConceptScore W3213641906C159654299 @default.
- W3213641906 hasConceptScore W3213641906C180754005 @default.
- W3213641906 hasConceptScore W3213641906C2908647359 @default.
- W3213641906 hasConceptScore W3213641906C54355233 @default.
- W3213641906 hasConceptScore W3213641906C71924100 @default.
- W3213641906 hasConceptScore W3213641906C86803240 @default.
- W3213641906 hasConceptScore W3213641906C99454951 @default.
- W3213641906 hasFunder F4320309872 @default.
- W3213641906 hasFunder F4320321006 @default.
- W3213641906 hasIssue "1" @default.
- W3213641906 hasLocation W32136419061 @default.
- W3213641906 hasLocation W32136419062 @default.
- W3213641906 hasLocation W32136419063 @default.
- W3213641906 hasLocation W32136419064 @default.
- W3213641906 hasLocation W32136419065 @default.
- W3213641906 hasOpenAccess W3213641906 @default.
- W3213641906 hasPrimaryLocation W32136419061 @default.
- W3213641906 hasRelatedWork W1016159219 @default.
- W3213641906 hasRelatedWork W2008843816 @default.
- W3213641906 hasRelatedWork W2051418585 @default.
- W3213641906 hasRelatedWork W2365604687 @default.
- W3213641906 hasRelatedWork W2401035697 @default.
- W3213641906 hasRelatedWork W2883538728 @default.
- W3213641906 hasRelatedWork W3164138798 @default.
- W3213641906 hasRelatedWork W4240578417 @default.
- W3213641906 hasRelatedWork W4286708100 @default.
- W3213641906 hasRelatedWork W3029642785 @default.
- W3213641906 hasVolume "11" @default.
- W3213641906 isParatext "false" @default.
- W3213641906 isRetracted "false" @default.
- W3213641906 magId "3213641906" @default.
- W3213641906 workType "article" @default.