FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213662018> ?p ?o ?g. }

• W3213662018 abstract "Abstract We developed an integrin αvβ3-specific liposomes, TR-conjugated liposomes (TR-LPs), loading IR783 for NIR imaging-guided both PTT and PDT. The TR-LPs was composed of soyabeanphosphatidylcholine, cholesterol, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine- N- [methoxy(polyethylene glycol)-2000] (DSPE-PEG) and TR-functionalized DSPE-PEG. IR783, NIR PTT/PDT diagnostic agents, were encapsulated in the hydrophilic core of the TR-LPs. DSPE-PEG had ability of reducing the absorption of TR-LPs by the reticuloendothelial system and increase the cycle time in body. RGD fragment on the TR peptide (TR = c(RGD)-AGYLLGHINLHHLAHL(Aib)HHIL-cys) enhanced the tumor selectivity of liposomes by specifically targeting integrin αvβ3-overexpressing cancer cells. Simultaneously, the rest of fragment on the TR peptide can be changed to the positive charge in the tumor microenvironment (pH 6.5), improving cellular uptake of photoagents at tumor site. We executed a set of in vitro and in vivo experiments to verify if, by functionalizing liposomes with an integrin αvβ3-specific and pH responding peptide, it is possible to achieve NIR imaging guided PTT/PDT for tumor treatment. TR-conjugated liposomes exhibited favorable physical and chemical stability, loading capacity, biocompatibility and tumor targeting. TR-LPs can safely and efficiently delivery IR783 to tumor sites to achieve their therapeutic function. IR783-TR-LPs is promising as a potentially safe and effective phototherapeutic agents for NIR fluorescence-guided tumor therapy applications." @default.
• W3213662018 created "2021-11-22" @default.
• W3213662018 creator A5014816105 @default.
• W3213662018 creator A5019971062 @default.
• W3213662018 creator A5032112116 @default.
• W3213662018 creator A5050232205 @default.
• W3213662018 creator A5066565410 @default.
• W3213662018 creator A5069522797 @default.
• W3213662018 date "2021-11-09" @default.
• W3213662018 modified "2023-09-25" @default.
• W3213662018 title "IR783 Encapsulated in TR-conjugated Liposomes for Enhancing NIR Imaging-guided Photothermal and Photodynamic Therapy" @default.
• W3213662018 cites W2569658671 @default.
• W3213662018 cites W2782710815 @default.
• W3213662018 cites W2474447669 @default.
• W3213662018 doi "https://doi.org/10.21203/rs.3.rs-1033993/v1" @default.
• W3213662018 hasPublicationYear "2021" @default.
• W3213662018 type Work @default.
• W3213662018 sameAs 3213662018 @default.
• W3213662018 citedByCount "0" @default.
• W3213662018 crossrefType "posted-content" @default.
• W3213662018 hasAuthorship W3213662018A5014816105 @default.
• W3213662018 hasAuthorship W3213662018A5019971062 @default.
• W3213662018 hasAuthorship W3213662018A5032112116 @default.
• W3213662018 hasAuthorship W3213662018A5050232205 @default.
• W3213662018 hasAuthorship W3213662018A5066565410 @default.
• W3213662018 hasAuthorship W3213662018A5069522797 @default.
• W3213662018 hasBestOaLocation W32136620181 @default.
• W3213662018 hasConcept C10138342 @default.
• W3213662018 hasConcept C112613896 @default.
• W3213662018 hasConcept C121332964 @default.
• W3213662018 hasConcept C12554922 @default.
• W3213662018 hasConcept C150903083 @default.
• W3213662018 hasConcept C162324750 @default.
• W3213662018 hasConcept C170493617 @default.
• W3213662018 hasConcept C171250308 @default.
• W3213662018 hasConcept C178790620 @default.
• W3213662018 hasConcept C182606246 @default.
• W3213662018 hasConcept C185154212 @default.
• W3213662018 hasConcept C185592680 @default.
• W3213662018 hasConcept C192562407 @default.
• W3213662018 hasConcept C195687474 @default.
• W3213662018 hasConcept C207001950 @default.
• W3213662018 hasConcept C2776964284 @default.
• W3213662018 hasConcept C2777230088 @default.
• W3213662018 hasConcept C2779281246 @default.
• W3213662018 hasConcept C2779820397 @default.
• W3213662018 hasConcept C2781323092 @default.
• W3213662018 hasConcept C502942594 @default.
• W3213662018 hasConcept C521977710 @default.
• W3213662018 hasConcept C54400483 @default.
• W3213662018 hasConcept C55493867 @default.
• W3213662018 hasConcept C57477423 @default.
• W3213662018 hasConcept C62520636 @default.
• W3213662018 hasConcept C71924100 @default.
• W3213662018 hasConcept C86803240 @default.
• W3213662018 hasConcept C91881484 @default.
• W3213662018 hasConceptScore W3213662018C10138342 @default.
• W3213662018 hasConceptScore W3213662018C112613896 @default.
• W3213662018 hasConceptScore W3213662018C121332964 @default.
• W3213662018 hasConceptScore W3213662018C12554922 @default.
• W3213662018 hasConceptScore W3213662018C150903083 @default.
• W3213662018 hasConceptScore W3213662018C162324750 @default.
• W3213662018 hasConceptScore W3213662018C170493617 @default.
• W3213662018 hasConceptScore W3213662018C171250308 @default.
• W3213662018 hasConceptScore W3213662018C178790620 @default.
• W3213662018 hasConceptScore W3213662018C182606246 @default.
• W3213662018 hasConceptScore W3213662018C185154212 @default.
• W3213662018 hasConceptScore W3213662018C185592680 @default.
• W3213662018 hasConceptScore W3213662018C192562407 @default.
• W3213662018 hasConceptScore W3213662018C195687474 @default.
• W3213662018 hasConceptScore W3213662018C207001950 @default.
• W3213662018 hasConceptScore W3213662018C2776964284 @default.
• W3213662018 hasConceptScore W3213662018C2777230088 @default.
• W3213662018 hasConceptScore W3213662018C2779281246 @default.
• W3213662018 hasConceptScore W3213662018C2779820397 @default.
• W3213662018 hasConceptScore W3213662018C2781323092 @default.
• W3213662018 hasConceptScore W3213662018C502942594 @default.
• W3213662018 hasConceptScore W3213662018C521977710 @default.
• W3213662018 hasConceptScore W3213662018C54400483 @default.
• W3213662018 hasConceptScore W3213662018C55493867 @default.
• W3213662018 hasConceptScore W3213662018C57477423 @default.
• W3213662018 hasConceptScore W3213662018C62520636 @default.
• W3213662018 hasConceptScore W3213662018C71924100 @default.
• W3213662018 hasConceptScore W3213662018C86803240 @default.
• W3213662018 hasConceptScore W3213662018C91881484 @default.
• W3213662018 hasLocation W32136620181 @default.
• W3213662018 hasOpenAccess W3213662018 @default.
• W3213662018 hasPrimaryLocation W32136620181 @default.
• W3213662018 hasRelatedWork W1967762287 @default.
• W3213662018 hasRelatedWork W1977594457 @default.
• W3213662018 hasRelatedWork W1992682676 @default.
• W3213662018 hasRelatedWork W2022512773 @default.
• W3213662018 hasRelatedWork W2022672213 @default.
• W3213662018 hasRelatedWork W2073599039 @default.
• W3213662018 hasRelatedWork W2884673227 @default.
• W3213662018 hasRelatedWork W3014765625 @default.
• W3213662018 hasRelatedWork W4318473831 @default.
• W3213662018 hasRelatedWork W4361282636 @default.
• W3213662018 isParatext "false" @default.
• W3213662018 isRetracted "false" @default.

• next