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• W3213710857 startingPage "3142" @default.
• W3213710857 abstract "Polycomb repressive complex 2 (PRC2) mediates histone H3K27me3 methylation and the stable transcriptional repression of a number of gene expression programs involved in the control of cellular identity during development and differentiation. Here, we report on the generation and on the characterization of a zebrafish line harboring a null allele of eed, a gene coding for an essential component of the PRC2. Homozygous eed-deficient mutants present a normal body plan development but display strong defects at the level of the digestive organs, such as reduced size of the pancreas, hepatic steatosis, and a loss of the intestinal structures, to die finally at around 10-12 days post fertilization. In addition, we found that PRC2 loss of function impairs neuronal differentiation in very specific and discrete areas of the brain and increases larval activity in locomotor assays. Our work highlights that zebrafish is a suited model to study human pathologies associated with PRC2 loss of function and H3K27me3 decrease." @default.
• W3213710857 created "2021-11-22" @default.
• W3213710857 creator A5010941913 @default.
• W3213710857 creator A5012666659 @default.
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• W3213710857 creator A5027911156 @default.
• W3213710857 creator A5030254838 @default.
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• W3213710857 creator A5076432438 @default.
• W3213710857 creator A5079753614 @default.
• W3213710857 creator A5082961482 @default.
• W3213710857 date "2021-11-12" @default.
• W3213710857 modified "2023-09-30" @default.
• W3213710857 title "Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish" @default.
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