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- W3213749137 abstract "Neuropathic pain is a condition that is difficult to treat and directly impact the quality of life of many patients. Thus, it is important to find new possible targets for medications in order to create new therapeutic agents. Glial cells play a significant role in mediating neuropathic pain. Activation of glial cells in the spinal cord results in the release of pro-inflammatory cytokines such as IL-33. IL-33 is an important pronociceptive cytokine, member of the IL-1 family, that signals via the IL-1 receptor-related protein ST2. The treatment to controlling neuropathic pain can be pharmacological attenuation of glial activation and IL-33 production. Neuropathic pain control can also be achieved by decreasing IL-33 actions on glial cells by targeting the transcription factor (NFkB) and MAP kinases (ERK, p38, and JNK) resulting on reduced production of hyperalgesic cytokines TNFα and IL-1β. We reviewed the importance of mechanisms underlying the development of neuropathic pain by glial cells, which led to identifying some possible new approaches to the treatment of neuropathic pain, based on IL-33 production by glial cells after nerve injury." @default.
- W3213749137 created "2021-11-22" @default.
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- W3213749137 date "2022-01-01" @default.
- W3213749137 modified "2023-09-24" @default.
- W3213749137 title "Interlinking interleukin-33 (IL-33), neuroinflammation and neuropathic pain" @default.
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- W3213749137 doi "https://doi.org/10.1016/b978-0-12-820589-1.00016-6" @default.
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