FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213754902> ?p ?o ?g. }

• W3213754902 endingPage "3072" @default.
• W3213754902 startingPage "3072" @default.
• W3213754902 abstract "Human cytomegalovirus (HCMV) infection is an important cause of morbidity and mortality in immunocompromised patients and a major etiological factor for congenital birth defects in newborns. Ganciclovir and its pro-drug valganciclovir are the preferred drugs in use today for prophylaxis and treatment of viremic patients. Due to long treatment times, patients are at risk for developing viral resistance to ganciclovir and to other drugs with a similar mechanism of action. We earlier found that the endothelin receptor B (ETBR) is upregulated during HCMV infection and that it plays an important role in the life cycle of this virus. Here, we tested the hypothesis that ETBR blockade could be used in the treatment of HCMV infection. As HCMV infection is specific to humans, we tested our hypothesis in human cell types that are relevant for HCMV pathogenesis; i.e., endothelial cells, epithelial cells and fibroblasts. We infected these cells with HCMV and treated them with the ETBR specific antagonist BQ788 or ETR antagonists that are approved by the FDA for treatment of pulmonary hypertension; macitentan, its metabolite ACT-132577, bosentan and ambrisentan, and as an anti-viral control, we used ganciclovir or letermovir. At concentrations expected to be relevant in vivo, macitentan, ACT-132577 and BQ788 effectively inhibited productive infection of HCMV. Of importance, macitentan also inhibited productive infection of a ganciclovir-resistant HCMV isolate. Our results suggest that binding or signaling through ETBR is crucial for viral replication, and that selected ETBR blockers inhibit HCMV infection." @default.
• W3213754902 created "2021-11-22" @default.
• W3213754902 creator A5011041014 @default.
• W3213754902 creator A5015258819 @default.
• W3213754902 creator A5033722717 @default.
• W3213754902 creator A5037879945 @default.
• W3213754902 creator A5073684893 @default.
• W3213754902 creator A5074662776 @default.
• W3213754902 creator A5084210628 @default.
• W3213754902 date "2021-11-08" @default.
• W3213754902 modified "2023-10-03" @default.
• W3213754902 title "The Endothelin Receptor Antagonist Macitentan Inhibits Human Cytomegalovirus Infection" @default.
• W3213754902 cites W1538422715 @default.
• W3213754902 cites W1783822653 @default.
• W3213754902 cites W1966894379 @default.
• W3213754902 cites W1977818394 @default.
• W3213754902 cites W1983963541 @default.
• W3213754902 cites W1984176331 @default.
• W3213754902 cites W1993678833 @default.
• W3213754902 cites W1996688582 @default.
• W3213754902 cites W1996817385 @default.
• W3213754902 cites W1999722506 @default.
• W3213754902 cites W2005017965 @default.
• W3213754902 cites W2007134676 @default.
• W3213754902 cites W2011471982 @default.
• W3213754902 cites W2012427126 @default.
• W3213754902 cites W2020358700 @default.
• W3213754902 cites W2024354287 @default.
• W3213754902 cites W2025252445 @default.
• W3213754902 cites W2031679468 @default.
• W3213754902 cites W2034075280 @default.
• W3213754902 cites W2046346267 @default.
• W3213754902 cites W2064975687 @default.
• W3213754902 cites W2065197515 @default.
• W3213754902 cites W2065505211 @default.
• W3213754902 cites W2071772149 @default.
• W3213754902 cites W2074109820 @default.
• W3213754902 cites W2091478221 @default.
• W3213754902 cites W2103683952 @default.
• W3213754902 cites W2104124112 @default.
• W3213754902 cites W2111796279 @default.
• W3213754902 cites W2124152342 @default.
• W3213754902 cites W2126489948 @default.
• W3213754902 cites W2129677994 @default.
• W3213754902 cites W2132124783 @default.
• W3213754902 cites W2150247173 @default.
• W3213754902 cites W2151624219 @default.
• W3213754902 cites W2152488221 @default.
• W3213754902 cites W2161156906 @default.
• W3213754902 cites W2167207109 @default.
• W3213754902 cites W2167351117 @default.
• W3213754902 cites W2171240223 @default.
• W3213754902 cites W2228518579 @default.
• W3213754902 cites W2256756668 @default.
• W3213754902 cites W2336726944 @default.
• W3213754902 cites W2465813018 @default.
• W3213754902 cites W2564574122 @default.
• W3213754902 cites W2581100233 @default.
• W3213754902 cites W2618380098 @default.
• W3213754902 cites W2800421806 @default.
• W3213754902 cites W2883530068 @default.
• W3213754902 cites W2924038702 @default.
• W3213754902 cites W3012183683 @default.
• W3213754902 cites W3043526999 @default.
• W3213754902 cites W3098358472 @default.
• W3213754902 cites W3165150661 @default.
• W3213754902 cites W4210978086 @default.
• W3213754902 doi "https://doi.org/10.3390/cells10113072" @default.
• W3213754902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8619441" @default.
• W3213754902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34831300" @default.
• W3213754902 hasPublicationYear "2021" @default.
• W3213754902 type Work @default.
• W3213754902 sameAs 3213754902 @default.
• W3213754902 citedByCount "2" @default.
• W3213754902 countsByYear W32137549022022 @default.
• W3213754902 crossrefType "journal-article" @default.
• W3213754902 hasAuthorship W3213754902A5011041014 @default.
• W3213754902 hasAuthorship W3213754902A5015258819 @default.
• W3213754902 hasAuthorship W3213754902A5033722717 @default.
• W3213754902 hasAuthorship W3213754902A5037879945 @default.
• W3213754902 hasAuthorship W3213754902A5073684893 @default.
• W3213754902 hasAuthorship W3213754902A5074662776 @default.
• W3213754902 hasAuthorship W3213754902A5084210628 @default.
• W3213754902 hasBestOaLocation W32137549021 @default.
• W3213754902 hasConcept C126322002 @default.
• W3213754902 hasConcept C144980905 @default.
• W3213754902 hasConcept C159047783 @default.
• W3213754902 hasConcept C170493617 @default.
• W3213754902 hasConcept C203014093 @default.
• W3213754902 hasConcept C2522874641 @default.
• W3213754902 hasConcept C2776317777 @default.
• W3213754902 hasConcept C2776345702 @default.
• W3213754902 hasConcept C2776409557 @default.
• W3213754902 hasConcept C2776724271 @default.
• W3213754902 hasConcept C2777732132 @default.
• W3213754902 hasConcept C2777965375 @default.
• W3213754902 hasConcept C2779820661 @default.
• W3213754902 hasConcept C2780727368 @default.

• next