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• W3213771311 abstract "Abstract Fluorescent light-up aptamers (FLAPs) emerged as valuable tools to visualize RNA, but are mostly limited by poor brightness, low photostability and high fluorescence background. In this study, we combine bivalent (silicon) rhodamine fluorophores with dimeric FLAPs to yield bright and photostable complexes with low picomolar dissociation constants. Our avidity-based approach resulted in extreme binding strength and high fluorogenicity, enabling single mRNA tracking in living cells." @default.
• W3213771311 created "2021-11-22" @default.
• W3213771311 creator A5008875274 @default.
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• W3213771311 date "2021-11-02" @default.
• W3213771311 modified "2023-09-23" @default.
• W3213771311 title "Bright, fluorogenic and photostable avidity probes for RNA imaging" @default.
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• W3213771311 doi "https://doi.org/10.1101/2021.11.02.466936" @default.
• W3213771311 hasPublicationYear "2021" @default.
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