Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213773904> ?p ?o ?g. }
- W3213773904 abstract "Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery remodeling that may subsequently culminate in right heart failure and premature death. Although there are currently both non-pharmacological (lung transplantation, etc.) and pharmacological (Sildenafil, Bosentan, and new oral drugs on trial) therapies available, PAH remains a serious and fatal pulmonary disease. As a unique medical treatment, traditional herbal medicine (THM) treatment has gradually exerted its advantages in treating PAH worldwide through a multi-level and multi-target approach. Additionally, the potential mechanisms of THM were deciphered, including suppression of proliferation and apoptosis of pulmonary artery smooth muscle cells, controlling the processes of inflammation and oxidative stress, and regulating vasoconstriction and ion channels. In this review, the effects and mechanisms of the frequently studied compound THM, single herbal preparations, and multiple active components from THM are comprehensively summarized, as well as their related mechanisms on several classical preclinical PAH models. It is worth mentioning that sodium tanshinone IIA sulfonate sodium and tetramethylpyrazine are under clinical trials and are considered the most promoting medicines for PAH treatment. Last, reverse pharmacology, a strategy to discover THM or THM-derived components, has also been proposed here for PAH. This review discusses the current state of THM, their working mechanisms against PAH, and prospects of reverse pharmacology, which are expected to facilitate the natural anti-PAH medicine discovery and development and its bench-to-bedside transformation." @default.
- W3213773904 created "2021-11-22" @default.
- W3213773904 creator A5029363724 @default.
- W3213773904 creator A5037660639 @default.
- W3213773904 creator A5044788727 @default.
- W3213773904 creator A5050106867 @default.
- W3213773904 creator A5074559466 @default.
- W3213773904 creator A5078018786 @default.
- W3213773904 creator A5078613274 @default.
- W3213773904 creator A5087877618 @default.
- W3213773904 date "2021-11-09" @default.
- W3213773904 modified "2023-10-18" @default.
- W3213773904 title "Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension" @default.
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