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- W3213786118 abstract "Arrhythmias are a critical health burden, responsible for a significant proportion of sudden cardiac death. They arise from inherited or acquired abnormalities in cardiac ion channels or their associated regulatory proteins functioning within cardiomyocytes. In opposite with the classical in vitro models, human induced pluripotent stem cells–derived cardiomyocytes (hiPSC-CMs) offer a patient-specific model that recapitulates disease phenotype and mirrors the reaction to pharmacotherapy. Thus far, the hiPSC-CMs model has genuinely improved our knowledge concerning both, the pathogenicity of genetic variants in inherited arrhythmias and the toxicity of some factors implicated in acquired forms of arrhythmia. Besides, as these cells preserve patient genetic background, they enable the customization of therapies and open thereby the door for personalized medicine. In this chapter, we will outline studies that leveraged the hiPSC-CMs model to explore the mechanism underlying inherited or acquired arrhythmic phenotypes and will point out its sustained limits." @default.
- W3213786118 created "2021-11-22" @default.
- W3213786118 creator A5011662649 @default.
- W3213786118 creator A5061249762 @default.
- W3213786118 creator A5064532873 @default.
- W3213786118 creator A5090270478 @default.
- W3213786118 date "2022-01-01" @default.
- W3213786118 modified "2023-10-16" @default.
- W3213786118 title "Induced pluripotent stem cells for modeling of cardiac arrhythmias" @default.
- W3213786118 cites W1579904960 @default.
- W3213786118 cites W1730627877 @default.
- W3213786118 cites W1776280496 @default.
- W3213786118 cites W1832288164 @default.
- W3213786118 cites W1845398286 @default.
- W3213786118 cites W1951903512 @default.
- W3213786118 cites W1963984360 @default.
- W3213786118 cites W1968779484 @default.
- W3213786118 cites W1970848503 @default.
- W3213786118 cites W1971590660 @default.
- W3213786118 cites W1984153793 @default.
- W3213786118 cites W1988720159 @default.
- W3213786118 cites W1996735711 @default.
- W3213786118 cites W1998190377 @default.
- W3213786118 cites W1998419541 @default.
- W3213786118 cites W1999148174 @default.
- W3213786118 cites W2010007998 @default.
- W3213786118 cites W2023839241 @default.
- W3213786118 cites W2026404421 @default.
- W3213786118 cites W2030290211 @default.
- W3213786118 cites W2045548568 @default.
- W3213786118 cites W2052976216 @default.
- W3213786118 cites W2055295116 @default.
- W3213786118 cites W2064015155 @default.
- W3213786118 cites W2064045324 @default.
- W3213786118 cites W2064204877 @default.
- W3213786118 cites W2065194179 @default.
- W3213786118 cites W2066767635 @default.
- W3213786118 cites W2069187704 @default.
- W3213786118 cites W2078311582 @default.
- W3213786118 cites W2079023701 @default.
- W3213786118 cites W2085050235 @default.
- W3213786118 cites W2085136138 @default.
- W3213786118 cites W2102389881 @default.
- W3213786118 cites W2104996733 @default.
- W3213786118 cites W2106854002 @default.
- W3213786118 cites W2115644752 @default.
- W3213786118 cites W2119327737 @default.
- W3213786118 cites W2128085444 @default.
- W3213786118 cites W2129911237 @default.
- W3213786118 cites W2133127571 @default.
- W3213786118 cites W2133808555 @default.
- W3213786118 cites W2138977668 @default.
- W3213786118 cites W2141241503 @default.
- W3213786118 cites W2147857057 @default.
- W3213786118 cites W2152635048 @default.
- W3213786118 cites W2155235762 @default.
- W3213786118 cites W2157706373 @default.
- W3213786118 cites W2165179483 @default.
- W3213786118 cites W2177611904 @default.
- W3213786118 cites W2192043288 @default.
- W3213786118 cites W2239331045 @default.
- W3213786118 cites W2260357887 @default.
- W3213786118 cites W2269807470 @default.
- W3213786118 cites W2274031004 @default.
- W3213786118 cites W2289935708 @default.
- W3213786118 cites W2293058057 @default.
- W3213786118 cites W2341765379 @default.
- W3213786118 cites W2392489729 @default.
- W3213786118 cites W2409162829 @default.
- W3213786118 cites W2415670168 @default.
- W3213786118 cites W2460253967 @default.
- W3213786118 cites W2476187554 @default.
- W3213786118 cites W2486747697 @default.
- W3213786118 cites W2506156156 @default.
- W3213786118 cites W2515600373 @default.
- W3213786118 cites W2525209473 @default.
- W3213786118 cites W2529271395 @default.
- W3213786118 cites W2533344724 @default.
- W3213786118 cites W2538189119 @default.
- W3213786118 cites W2538466402 @default.
- W3213786118 cites W2544855682 @default.
- W3213786118 cites W2561960085 @default.
- W3213786118 cites W2581157143 @default.
- W3213786118 cites W2583216773 @default.
- W3213786118 cites W2591534501 @default.
- W3213786118 cites W2593518655 @default.
- W3213786118 cites W2596329858 @default.
- W3213786118 cites W2606947132 @default.
- W3213786118 cites W2611938973 @default.
- W3213786118 cites W2617602537 @default.
- W3213786118 cites W2620839485 @default.
- W3213786118 cites W2624758647 @default.
- W3213786118 cites W2638423511 @default.
- W3213786118 cites W2725483989 @default.
- W3213786118 cites W2735818838 @default.
- W3213786118 cites W2738118069 @default.
- W3213786118 cites W2742550673 @default.
- W3213786118 cites W2760573373 @default.