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- W3213850859 abstract "Introduction: The United Kingdom (UK) was one of the first countries in the world providing mRNA (Pfizer-BioNTech) and adenovirus-based (Oxford-AstraZeneca) vaccines against SARSCoV- 2 for its population. By mid-May 2021, over 36 million British citizens had received at least one dose of COVID-19 vaccine. Aim: We described clinical, MRI, laboratory features, therapy, and outcomes of five COVID-19 vaccine-related cases of acute demyelinating events with onset between February and May 2021. Case 1: A 57-year-old man presented paraparesis, instability and bladder dysfunction 2 weeks after AstraZeneca vaccine jab. MRI showed lesions in the brainstem, cerebellum and cerebral hemispheres and a C3-C6 lesion. Myelin-oligodendrocyte-glycoprotein IgG (MOG-IgG) were positive. Incomplete recovery after 1 month. Case 2: A 36-year-old lady developed traverse myelitis (TM) and left optic neuritis (ON) after 2 weeks from Pfizer vaccine jab. MRI showed enhancement of left optic nerve and T10-T11 and T12-conus lesions. Oligoclonal bands (OCBs) restricted in cerebrospinal fluid (CSF) were found. MOG-IgG, aquaporin-4-IgG (AQP4-IgG) were negative. Incomplete recovery after 1 month . Case 3: A 50-year-old lady presented bilateral facial weakness and visual loss after 10 days from AstraZeneca vaccine jab. Visual acuity was reduced in both eyes. MRI showed enhancement along the facial nerves. MOG-IgG, AQP4-IgG and OCBs were negative. Incomplete recovery after 1 month. Case 4: A 44-year-old man, 2 weeks following AstraZeneca vaccine, developed progressive dyspnoea, chest pain and diplopia with rapid deterioration to quadriplegia and respiratory failure requiring mechanical ventilation. MRI showed bilateral multiple lesions involving cerebral hemispheres, thalami, brainstem and spinal cord. MOG-IgG, AQP-4 IgG and OCBs were negative. The patient died. Case 5: A 57-year-old lady with seronegative relapsing TM since 2009 and fulfilling neither multiple sclerosis nor NMOSD diagnostic criteria. After 1 week from AstraZeneca vaccine jab, she presented TM symptoms and a new active T9-T10 lesion. Poor recovery after 2 months. Conclusions: It is currently unclear whether the association is greater than chance or whether the Oxford-AstraZeneca vaccine has a greater incidence because used more frequently in the UK than the Pfizer vaccine. However, viral illnesses and vaccinations have been reported to trigger demyelinating events, including MOG-IgG disease, associated with ADEM." @default.
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- W3213850859 date "2021-01-01" @default.
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- W3213850859 title "Acute demyelinating events triggered by COVID-19 vaccines: Case series" @default.
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