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• W3213850907 abstract "Mitochondrial dysfunction is a hallmark of aging. Mitochondrial genome (mtDNA) instability contributes to mitochondrial dysfunction, and mtDNA mutagenesis may contribute to aging. However, the origin of mtDNA mutations remains somewhat controversial. The goals of this review are to introduce and review recent literature on mtDNA mutagenesis and aging, address recent animal and epidemiological evidence for the effects of chemicals on mtDNA damage and mutagenesis, propose hypotheses regarding the contribution of environmental toxicant exposure to mtDNA mutagenesis in the context of aging, and suggest future directions and approaches for environmental health researchers. Stressors such as pollutants, pharmaceuticals, and ultraviolet radiation can damage the mitochondrial genome or disrupt mtDNA replication, repair, and organelle homeostatic processes, potentially influencing the rate of accumulation of mtDNA mutations. Accelerated mtDNA mutagenesis could contribute to aging, diseases of aging, and sensitize individuals with pathogenic mtDNA variants to stressors. We propose three potential mechanisms of toxicant-induced effects on mtDNA mutagenesis over lifespan: (1) increased de novo mtDNA mutations, (2) altered frequencies of mtDNA mutations, or (3) both. There are remarkably few studies that have investigated the impact of environmental chemical exposures on mtDNA instability and mutagenesis, and even fewer in the context of aging. More studies are warranted because people are exposed to tens of thousands of chemicals, and are living longer. Finally, we suggest that toxicant-induced mtDNA damage and mutational signatures may be a sensitive biomarker for some exposures." @default.
• W3213850907 created "2021-11-22" @default.
• W3213850907 creator A5015141183 @default.
• W3213850907 creator A5082289426 @default.
• W3213850907 date "2021-11-11" @default.
• W3213850907 modified "2023-10-10" @default.
• W3213850907 title "Mitochondrial DNA Mutagenesis: Feature of and Biomarker for Environmental Exposures and Aging" @default.
• W3213850907 cites W1518704304 @default.
• W3213850907 cites W1819623049 @default.
• W3213850907 cites W1968791049 @default.
• W3213850907 cites W1968952472 @default.
• W3213850907 cites W1979276801 @default.
• W3213850907 cites W1996813968 @default.
• W3213850907 cites W1997617471 @default.
• W3213850907 cites W2000730064 @default.
• W3213850907 cites W2001161771 @default.
• W3213850907 cites W2003712218 @default.
• W3213850907 cites W2004807060 @default.
• W3213850907 cites W2009448390 @default.
• W3213850907 cites W2017363253 @default.
• W3213850907 cites W2018204941 @default.
• W3213850907 cites W2020485198 @default.
• W3213850907 cites W2026609135 @default.
• W3213850907 cites W2026779731 @default.
• W3213850907 cites W2028335500 @default.
• W3213850907 cites W2033829899 @default.
• W3213850907 cites W2033832481 @default.
• W3213850907 cites W2044897807 @default.
• W3213850907 cites W2052439110 @default.
• W3213850907 cites W2053779702 @default.
• W3213850907 cites W2056563036 @default.
• W3213850907 cites W2056886321 @default.
• W3213850907 cites W2057695252 @default.
• W3213850907 cites W2066235091 @default.
• W3213850907 cites W2069392233 @default.
• W3213850907 cites W2069555799 @default.
• W3213850907 cites W2069736060 @default.
• W3213850907 cites W2072328142 @default.
• W3213850907 cites W2073693479 @default.
• W3213850907 cites W2076693703 @default.
• W3213850907 cites W2079683785 @default.
• W3213850907 cites W2080272457 @default.
• W3213850907 cites W2081500201 @default.
• W3213850907 cites W2087121074 @default.
• W3213850907 cites W2088995367 @default.
• W3213850907 cites W2091151750 @default.
• W3213850907 cites W2099142102 @default.
• W3213850907 cites W2103562463 @default.
• W3213850907 cites W2117795149 @default.
• W3213850907 cites W2120694986 @default.
• W3213850907 cites W2123696055 @default.
• W3213850907 cites W2127380523 @default.
• W3213850907 cites W2131415852 @default.
• W3213850907 cites W2143197030 @default.
• W3213850907 cites W2148071420 @default.
• W3213850907 cites W2149551151 @default.
• W3213850907 cites W2153029275 @default.
• W3213850907 cites W2155949689 @default.
• W3213850907 cites W2156603613 @default.
• W3213850907 cites W2158030172 @default.
• W3213850907 cites W2162006879 @default.
• W3213850907 cites W2162288115 @default.
• W3213850907 cites W2164728918 @default.
• W3213850907 cites W2165245853 @default.
• W3213850907 cites W2166664098 @default.
• W3213850907 cites W2191690548 @default.
• W3213850907 cites W2215582843 @default.
• W3213850907 cites W2238713843 @default.
• W3213850907 cites W2289876562 @default.
• W3213850907 cites W2290989326 @default.
• W3213850907 cites W2300592006 @default.
• W3213850907 cites W2309624102 @default.
• W3213850907 cites W2311013422 @default.
• W3213850907 cites W2315512556 @default.
• W3213850907 cites W2315712516 @default.
• W3213850907 cites W2332787986 @default.
• W3213850907 cites W2336416528 @default.
• W3213850907 cites W2340042352 @default.
• W3213850907 cites W2340822561 @default.
• W3213850907 cites W2344148285 @default.
• W3213850907 cites W2344482801 @default.
• W3213850907 cites W2401291964 @default.
• W3213850907 cites W2433744397 @default.
• W3213850907 cites W2472325629 @default.
• W3213850907 cites W2511456620 @default.
• W3213850907 cites W2511725062 @default.
• W3213850907 cites W2548408750 @default.
• W3213850907 cites W2557858237 @default.
• W3213850907 cites W2570063207 @default.
• W3213850907 cites W2575430673 @default.
• W3213850907 cites W2591797841 @default.
• W3213850907 cites W2593008820 @default.
• W3213850907 cites W2598503628 @default.
• W3213850907 cites W2607644287 @default.
• W3213850907 cites W2609318150 @default.
• W3213850907 cites W2609453211 @default.
• W3213850907 cites W2622547526 @default.
• W3213850907 cites W2732596166 @default.

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