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- W3213852891 abstract "Because the Staphylococcus aureus is one of the most well-known pathogens associated with medical devices and nosocomial infections, the aim of the study was to examine antibiofilm potential of emodin against it.Antibacterial activity was examined through microdilution assay. Antibiofilm testing included crystal violet staining of biofilm biomass and morphology analysis by Atomic force microscopy (AFM). Furthermore, aerobic respiration was monitored using the Micro-Oxymax respirometer. For investigation of gene expression qRT-PCR was performed. Emodin demonstrated strong antibacterial activity and ability to inhibit biofilm formation of all tested strains. The effect on preformed biofilms was spotted in few strains. AFM revealed that emodin affects biofilm structure and roughness. Monitoring of respiration under emodin treatment in planktonic and biofilm form revealed that emodin influenced aerobic respiration. Moreover, qRT-PCR showed that emodin modulates expression of icaA, icaD, srrA and srrB genes, as well as RNAIII, and that this activity was strain-specific.The results obtained in this study indicate the novel antibiofilm activity of emodin and its multiple pathways of action.This is the first study that examined pathways through which emodin expressed its antibiofilm activity." @default.
- W3213852891 created "2021-11-22" @default.
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- W3213852891 date "2022-03-01" @default.
- W3213852891 modified "2023-10-13" @default.
- W3213852891 title "Elucidating the antibiofilm activity of Frangula emodin against Staphylococcus aureus biofilms" @default.
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- W3213852891 doi "https://doi.org/10.1111/jam.15360" @default.
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