Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213858955> ?p ?o ?g. }
- W3213858955 endingPage "110187" @default.
- W3213858955 startingPage "110187" @default.
- W3213858955 abstract "Protein Phosphatase 2A (PP2A), a main serine/threonine phosphatase, plays a profibrotic role in the development of different organs. However, the role and mechanisms of PP2Acα in fibroblast activation and kidney fibrosis are not fully known. Here we found that PP2Acα expression was upregulated in kidney tissue of chronic kidney disease (CKD) patients and unilateral ureter obstructive (UUO) mice. Ablation of fibroblast PP2Acα alleviates fibroblast activation and kidney fibrosis in mouse kidneys with UUO nephropathy compared with the control littermates. In primary cultured fibroblasts, PP2Acα deletion restrains TGFβ1-induced fibroblast activation, which is accompanied by increased phosphorylation of the extracellular regulated kinase (ERK). Blocking ERK pathway activation by PD98059 could promote fibroblast activation, indicating that PP2Acα promotes TGFβ1-induced fibroblast activation via suppressing ERK pathway. Consistently, in vivo, the activation of ERK pathway was upregulated by PP2Acα ablation in kidney fibroblasts. Together, these data uncover that PP2Acα may promote fibroblast activation and kidney fibrosis via suppressing ERK pathway, suggesting that targeting PP2Acα may provide a therapeutic effect for CKD." @default.
- W3213858955 created "2021-11-22" @default.
- W3213858955 creator A5005318671 @default.
- W3213858955 creator A5012275120 @default.
- W3213858955 creator A5017191784 @default.
- W3213858955 creator A5037936921 @default.
- W3213858955 creator A5091454967 @default.
- W3213858955 date "2022-02-01" @default.
- W3213858955 modified "2023-10-15" @default.
- W3213858955 title "PP2A Catalytic Subunit α promotes fibroblast activation and kidney fibrosis via ERK pathway" @default.
- W3213858955 cites W1804140162 @default.
- W3213858955 cites W184982843 @default.
- W3213858955 cites W1918138029 @default.
- W3213858955 cites W1963647498 @default.
- W3213858955 cites W1969715546 @default.
- W3213858955 cites W1972236331 @default.
- W3213858955 cites W1973502241 @default.
- W3213858955 cites W1974926454 @default.
- W3213858955 cites W1987474302 @default.
- W3213858955 cites W1989575334 @default.
- W3213858955 cites W1992060900 @default.
- W3213858955 cites W1998809668 @default.
- W3213858955 cites W2003060606 @default.
- W3213858955 cites W2017958579 @default.
- W3213858955 cites W2018079417 @default.
- W3213858955 cites W2033122114 @default.
- W3213858955 cites W2044982400 @default.
- W3213858955 cites W2054915804 @default.
- W3213858955 cites W2055907704 @default.
- W3213858955 cites W2056056517 @default.
- W3213858955 cites W2056123267 @default.
- W3213858955 cites W2061243113 @default.
- W3213858955 cites W2061283489 @default.
- W3213858955 cites W2068220646 @default.
- W3213858955 cites W2111742556 @default.
- W3213858955 cites W2122349103 @default.
- W3213858955 cites W2122565002 @default.
- W3213858955 cites W2126361876 @default.
- W3213858955 cites W2140475188 @default.
- W3213858955 cites W2140801345 @default.
- W3213858955 cites W2160109224 @default.
- W3213858955 cites W2164600890 @default.
- W3213858955 cites W2169981609 @default.
- W3213858955 cites W2411419987 @default.
- W3213858955 cites W2470157805 @default.
- W3213858955 cites W2519386099 @default.
- W3213858955 cites W2611898194 @default.
- W3213858955 cites W2884837669 @default.
- W3213858955 cites W2888812846 @default.
- W3213858955 cites W2896677975 @default.
- W3213858955 cites W2922278038 @default.
- W3213858955 cites W2936557403 @default.
- W3213858955 cites W2965247863 @default.
- W3213858955 cites W2978562320 @default.
- W3213858955 cites W4241668253 @default.
- W3213858955 cites W4244774747 @default.
- W3213858955 doi "https://doi.org/10.1016/j.cellsig.2021.110187" @default.
- W3213858955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34780974" @default.
- W3213858955 hasPublicationYear "2022" @default.
- W3213858955 type Work @default.
- W3213858955 sameAs 3213858955 @default.
- W3213858955 citedByCount "0" @default.
- W3213858955 crossrefType "journal-article" @default.
- W3213858955 hasAuthorship W3213858955A5005318671 @default.
- W3213858955 hasAuthorship W3213858955A5012275120 @default.
- W3213858955 hasAuthorship W3213858955A5017191784 @default.
- W3213858955 hasAuthorship W3213858955A5037936921 @default.
- W3213858955 hasAuthorship W3213858955A5091454967 @default.
- W3213858955 hasConcept C11960822 @default.
- W3213858955 hasConcept C126322002 @default.
- W3213858955 hasConcept C134018914 @default.
- W3213858955 hasConcept C178666793 @default.
- W3213858955 hasConcept C185592680 @default.
- W3213858955 hasConcept C202751555 @default.
- W3213858955 hasConcept C2780091579 @default.
- W3213858955 hasConcept C2780381497 @default.
- W3213858955 hasConcept C2780559512 @default.
- W3213858955 hasConcept C389152 @default.
- W3213858955 hasConcept C502942594 @default.
- W3213858955 hasConcept C55493867 @default.
- W3213858955 hasConcept C57074206 @default.
- W3213858955 hasConcept C62478195 @default.
- W3213858955 hasConcept C71924100 @default.
- W3213858955 hasConcept C86803240 @default.
- W3213858955 hasConcept C95444343 @default.
- W3213858955 hasConceptScore W3213858955C11960822 @default.
- W3213858955 hasConceptScore W3213858955C126322002 @default.
- W3213858955 hasConceptScore W3213858955C134018914 @default.
- W3213858955 hasConceptScore W3213858955C178666793 @default.
- W3213858955 hasConceptScore W3213858955C185592680 @default.
- W3213858955 hasConceptScore W3213858955C202751555 @default.
- W3213858955 hasConceptScore W3213858955C2780091579 @default.
- W3213858955 hasConceptScore W3213858955C2780381497 @default.
- W3213858955 hasConceptScore W3213858955C2780559512 @default.
- W3213858955 hasConceptScore W3213858955C389152 @default.
- W3213858955 hasConceptScore W3213858955C502942594 @default.
- W3213858955 hasConceptScore W3213858955C55493867 @default.
- W3213858955 hasConceptScore W3213858955C57074206 @default.