FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213881488> ?p ?o ?g. }

• W3213881488 abstract "The porcine respiratory disease complex (PRDC) is responsible for significant economic losses in the pig industry worldwide. Porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus are major viral contributors to PRDC. Vaccines are cost-effective measures for controlling PRRS, however, their efficacy in the context of co-infections has been poorly investigated. In this study, we aimed to determine the effect of PRRSV-2 and swine influenza H3N2 virus co-infection on the efficacy of PRRSV modified live virus (MLV) vaccination, which is widely used in the field. Following simultaneous challenge with contemporary PRRSV-2 and H3N2 field isolates, we found that the protective effect of PRRS MLV vaccination on clinical disease and pathology was abrogated, although viral load was unaffected and antibody responses were enhanced. In contrast, co-infection in non-immunized animals reduced PRRSV-2 viremia and H3N2 virus load in the upper respiratory tract and potentiated T cell responses against both PRRSV-2 and H3N2 in the lung. Further analysis suggested that an upregulation of inhibitory cytokines gene expression in the lungs of vaccinated pigs may have influenced responses to H3N2 and PRRSV-2. These findings provide important insights into the effect of viral co-infections on PRRS vaccine efficacy that may help identify more effective vaccination strategies against PRDC in the field." @default.
• W3213881488 created "2021-11-22" @default.
• W3213881488 creator A5001566251 @default.
• W3213881488 creator A5003079660 @default.
• W3213881488 creator A5006169378 @default.
• W3213881488 creator A5011190153 @default.
• W3213881488 creator A5015145300 @default.
• W3213881488 creator A5016982349 @default.
• W3213881488 creator A5041390547 @default.
• W3213881488 creator A5061558411 @default.
• W3213881488 creator A5064040548 @default.
• W3213881488 creator A5070293514 @default.
• W3213881488 creator A5086250562 @default.
• W3213881488 creator A5090821047 @default.
• W3213881488 creator A5091169979 @default.
• W3213881488 date "2021-11-11" @default.
• W3213881488 modified "2023-09-27" @default.
• W3213881488 title "Simultaneous Infection With Porcine Reproductive and Respiratory Syndrome and Influenza Viruses Abrogates Clinical Protection Induced by Live Attenuated Porcine Reproductive and Respiratory Syndrome Vaccination" @default.
• W3213881488 cites W1502260800 @default.
• W3213881488 cites W1577577364 @default.
• W3213881488 cites W1893499718 @default.
• W3213881488 cites W1976334259 @default.
• W3213881488 cites W1988186335 @default.
• W3213881488 cites W2017607845 @default.
• W3213881488 cites W2020316997 @default.
• W3213881488 cites W2029598269 @default.
• W3213881488 cites W2033116698 @default.
• W3213881488 cites W2051931274 @default.
• W3213881488 cites W2074613929 @default.
• W3213881488 cites W2078533322 @default.
• W3213881488 cites W2079278536 @default.
• W3213881488 cites W2080308041 @default.
• W3213881488 cites W2081771153 @default.
• W3213881488 cites W2082158671 @default.
• W3213881488 cites W2088990970 @default.
• W3213881488 cites W2092471236 @default.
• W3213881488 cites W2106908706 @default.
• W3213881488 cites W2107696055 @default.
• W3213881488 cites W2119819215 @default.
• W3213881488 cites W2138124359 @default.
• W3213881488 cites W2140296277 @default.
• W3213881488 cites W2146278938 @default.
• W3213881488 cites W2153733982 @default.
• W3213881488 cites W2154508796 @default.
• W3213881488 cites W2158372391 @default.
• W3213881488 cites W2162819574 @default.
• W3213881488 cites W2346826388 @default.
• W3213881488 cites W2407648086 @default.
• W3213881488 cites W2605606775 @default.
• W3213881488 cites W2614681664 @default.
• W3213881488 cites W2627077408 @default.
• W3213881488 cites W2746352180 @default.
• W3213881488 cites W2788283216 @default.
• W3213881488 cites W2788445858 @default.
• W3213881488 cites W2790221875 @default.
• W3213881488 cites W2790608336 @default.
• W3213881488 cites W2804625537 @default.
• W3213881488 cites W2891140752 @default.
• W3213881488 cites W2892820092 @default.
• W3213881488 cites W2899580676 @default.
• W3213881488 cites W2918013093 @default.
• W3213881488 cites W2937230536 @default.
• W3213881488 cites W2942161022 @default.
• W3213881488 cites W2970833931 @default.
• W3213881488 cites W2980878090 @default.
• W3213881488 cites W2985116520 @default.
• W3213881488 cites W2989404448 @default.
• W3213881488 cites W2989804497 @default.
• W3213881488 cites W2991094040 @default.
• W3213881488 cites W3022799675 @default.
• W3213881488 cites W3026037054 @default.
• W3213881488 cites W3035564235 @default.
• W3213881488 cites W3037575219 @default.
• W3213881488 cites W3039735051 @default.
• W3213881488 cites W3088691199 @default.
• W3213881488 cites W3104502569 @default.
• W3213881488 cites W3112978058 @default.
• W3213881488 cites W3128502421 @default.
• W3213881488 cites W3130193275 @default.
• W3213881488 cites W3134455259 @default.
• W3213881488 cites W3152715442 @default.
• W3213881488 cites W3156301705 @default.
• W3213881488 cites W3173323933 @default.
• W3213881488 cites W4211099578 @default.
• W3213881488 cites W4211107894 @default.
• W3213881488 doi "https://doi.org/10.3389/fimmu.2021.758368" @default.
• W3213881488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8632230" @default.
• W3213881488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34858411" @default.
• W3213881488 hasPublicationYear "2021" @default.
• W3213881488 type Work @default.
• W3213881488 sameAs 3213881488 @default.
• W3213881488 citedByCount "10" @default.
• W3213881488 countsByYear W32138814882022 @default.
• W3213881488 countsByYear W32138814882023 @default.
• W3213881488 crossrefType "journal-article" @default.
• W3213881488 hasAuthorship W3213881488A5001566251 @default.
• W3213881488 hasAuthorship W3213881488A5003079660 @default.
• W3213881488 hasAuthorship W3213881488A5006169378 @default.
• W3213881488 hasAuthorship W3213881488A5011190153 @default.
• W3213881488 hasAuthorship W3213881488A5015145300 @default.

• next