Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213922466> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W3213922466 abstract "<p></p><p>Antibody-antigen interaction – at antigenic local environments called B-cell epitopes – is a prominent mechanism for neutralization of infection. Effective mimicry, and display, of B-cell epitopes is key to vaccine design. Here, a physical approach is evaluated for the discovery of epitopes which evolve slowly over closely related pathogens (conserved epitopes). The approach is 1) protein flexibility-based and 2) demonstrated with clinically relevant enveloped viruses, simulated via molecular dynamics. The approach is validated against 1) seven structurally characterized enveloped virus epitopes which evolved the least (out of thirty-eight enveloped virus-antibody structures) and 2) eight preexisting epitope and peptide discovery algorithms. Rationale for a new benchmarking scheme is presented. A data-driven epitope clustering algorithm is introduced. The prediction of eleven Zika virus epitopes (for future exploration on recombinant vaccine technologies) is demonstrated. For the first time, protein flexibility is shown to outperform solvent accessible surface area as an epitope discovery metric.</p><p></p>" @default.
- W3213922466 created "2021-11-22" @default.
- W3213922466 creator A5023908831 @default.
- W3213922466 creator A5025331603 @default.
- W3213922466 creator A5055862401 @default.
- W3213922466 date "2020-12-10" @default.
- W3213922466 modified "2023-09-24" @default.
- W3213922466 title "B-Cell Epitope Discovery: The First Protein Flexibility-Based Algorithm – Zika Virus Conserved Epitope Demonstration" @default.
- W3213922466 doi "https://doi.org/10.26434/chemrxiv.12834977.v3" @default.
- W3213922466 hasPublicationYear "2020" @default.
- W3213922466 type Work @default.
- W3213922466 sameAs 3213922466 @default.
- W3213922466 citedByCount "0" @default.
- W3213922466 crossrefType "posted-content" @default.
- W3213922466 hasAuthorship W3213922466A5023908831 @default.
- W3213922466 hasAuthorship W3213922466A5025331603 @default.
- W3213922466 hasAuthorship W3213922466A5055862401 @default.
- W3213922466 hasBestOaLocation W32139224661 @default.
- W3213922466 hasConcept C159047783 @default.
- W3213922466 hasConcept C159654299 @default.
- W3213922466 hasConcept C195616568 @default.
- W3213922466 hasConcept C2522874641 @default.
- W3213922466 hasConcept C2777053367 @default.
- W3213922466 hasConcept C2781241564 @default.
- W3213922466 hasConcept C54355233 @default.
- W3213922466 hasConcept C70721500 @default.
- W3213922466 hasConcept C78598654 @default.
- W3213922466 hasConcept C86803240 @default.
- W3213922466 hasConceptScore W3213922466C159047783 @default.
- W3213922466 hasConceptScore W3213922466C159654299 @default.
- W3213922466 hasConceptScore W3213922466C195616568 @default.
- W3213922466 hasConceptScore W3213922466C2522874641 @default.
- W3213922466 hasConceptScore W3213922466C2777053367 @default.
- W3213922466 hasConceptScore W3213922466C2781241564 @default.
- W3213922466 hasConceptScore W3213922466C54355233 @default.
- W3213922466 hasConceptScore W3213922466C70721500 @default.
- W3213922466 hasConceptScore W3213922466C78598654 @default.
- W3213922466 hasConceptScore W3213922466C86803240 @default.
- W3213922466 hasLocation W32139224661 @default.
- W3213922466 hasOpenAccess W3213922466 @default.
- W3213922466 hasPrimaryLocation W32139224661 @default.
- W3213922466 hasRelatedWork W19835385 @default.
- W3213922466 hasRelatedWork W20044489 @default.
- W3213922466 hasRelatedWork W23697950 @default.
- W3213922466 hasRelatedWork W26620643 @default.
- W3213922466 hasRelatedWork W27724709 @default.
- W3213922466 hasRelatedWork W29457247 @default.
- W3213922466 hasRelatedWork W31269597 @default.
- W3213922466 hasRelatedWork W33944442 @default.
- W3213922466 hasRelatedWork W34605779 @default.
- W3213922466 hasRelatedWork W36583373 @default.
- W3213922466 isParatext "false" @default.
- W3213922466 isRetracted "false" @default.
- W3213922466 magId "3213922466" @default.
- W3213922466 workType "article" @default.