FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3213929596> ?p ?o ?g. }

• W3213929596 endingPage "3116" @default.
• W3213929596 startingPage "3116" @default.
• W3213929596 abstract "Cladribine (CLAD) is a deoxyadenosine analogue prodrug which is given in multiple sclerosis (MS) as two short oral treatment courses 12 months apart. Reconstitution of adaptive immune function following selective immune cell depletion is the presumed mode of action. In this exploratory study, we investigated the impact of CLAD tablets on immune cell surface molecules for adhesion (CAMs) and costimulation (CoSs) in people with MS (pwMS). We studied 18 pwMS who started treatment with CLAD and 10 healthy controls (HCs). Peripheral blood mononuclear cells were collected at baseline and every 3 months throughout a 24-month period. We analysed ICAM-1, LFA-1, CD28, HLADR, CD154, CD44, VLA-4 (CD49d/CD29), PSGL-1 and PD-1 with regard to their expression on B and T cells (T helper (Th) and cytotoxic T cells (cT)) and surface density (mean fluorescence intensity, MFI) by flow cytometry. The targeted analysis of CAM and CoS on the surface of immune cells in pwMS revealed a higher percentage of ICAM-1 (B cells, Th, cT), LFA-1 (B cells, cT), HLADR (B cells, cT), CD28 (cT) and CD154 (Th). In pwMS, we found lower frequencies of Th and cT cells expressing PSGL-1 and B cells for the inhibitory signal PD-1, whereas the surface expression of LFA-1 on cT and of HLADR on B cells was denser. Twenty-four months after the first CLAD cycle, the frequencies of B cells expressing CD44, CD29 and CD49d were lower compared with the baseline, together with decreased densities of ICAM-1, CD44 and HLADR. The rate of CD154 expressing Th cells dropped at 12 months. For cT, no changes were seen for frequency or density. Immune reconstitution by oral CLAD was associated with modification of the pro-migratory and -inflammatory surface patterns of CAMs and CoSs in immune cell subsets. This observation pertains primarily to B cells, which are key cells underlying MS pathogenesis." @default.
• W3213929596 created "2021-11-22" @default.
• W3213929596 creator A5003586612 @default.
• W3213929596 creator A5015280776 @default.
• W3213929596 creator A5044375884 @default.
• W3213929596 creator A5053256015 @default.
• W3213929596 creator A5066234732 @default.
• W3213929596 creator A5068366638 @default.
• W3213929596 creator A5077531224 @default.
• W3213929596 creator A5089131482 @default.
• W3213929596 creator A5090491021 @default.
• W3213929596 date "2021-11-10" @default.
• W3213929596 modified "2023-10-16" @default.
• W3213929596 title "Cladribine Alters Immune Cell Surface Molecules for Adhesion and Costimulation: Further Insights to the Mode of Action in Multiple Sclerosis" @default.
• W3213929596 cites W1510398720 @default.
• W3213929596 cites W1514064771 @default.
• W3213929596 cites W1566384842 @default.
• W3213929596 cites W1579666322 @default.
• W3213929596 cites W1598569216 @default.
• W3213929596 cites W1816311090 @default.
• W3213929596 cites W1978683506 @default.
• W3213929596 cites W1981265882 @default.
• W3213929596 cites W1996325159 @default.
• W3213929596 cites W2005540893 @default.
• W3213929596 cites W2005701667 @default.
• W3213929596 cites W2007217012 @default.
• W3213929596 cites W2018456133 @default.
• W3213929596 cites W2020956642 @default.
• W3213929596 cites W2024524532 @default.
• W3213929596 cites W2026339937 @default.
• W3213929596 cites W2029344316 @default.
• W3213929596 cites W2031254657 @default.
• W3213929596 cites W2046369009 @default.
• W3213929596 cites W2053993475 @default.
• W3213929596 cites W2064017800 @default.
• W3213929596 cites W2076465777 @default.
• W3213929596 cites W2076515299 @default.
• W3213929596 cites W2091601326 @default.
• W3213929596 cites W2096234619 @default.
• W3213929596 cites W2100640696 @default.
• W3213929596 cites W2104195747 @default.
• W3213929596 cites W2108005154 @default.
• W3213929596 cites W2109044040 @default.
• W3213929596 cites W2109737182 @default.
• W3213929596 cites W2111021842 @default.
• W3213929596 cites W2123434491 @default.
• W3213929596 cites W2127424425 @default.
• W3213929596 cites W2135403800 @default.
• W3213929596 cites W2136395412 @default.
• W3213929596 cites W2145744908 @default.
• W3213929596 cites W2163280031 @default.
• W3213929596 cites W2465133659 @default.
• W3213929596 cites W2588687399 @default.
• W3213929596 cites W2756864941 @default.
• W3213929596 cites W2783468163 @default.
• W3213929596 cites W2791760987 @default.
• W3213929596 cites W2796223745 @default.
• W3213929596 cites W2800921577 @default.
• W3213929596 cites W2805243014 @default.
• W3213929596 cites W2889190248 @default.
• W3213929596 cites W2900596677 @default.
• W3213929596 cites W2914770914 @default.
• W3213929596 cites W2925159601 @default.
• W3213929596 cites W2949139014 @default.
• W3213929596 cites W3003957694 @default.
• W3213929596 cites W3005795963 @default.
• W3213929596 cites W3016526220 @default.
• W3213929596 cites W3048887029 @default.
• W3213929596 cites W3080556761 @default.
• W3213929596 cites W3091444236 @default.
• W3213929596 cites W3153504824 @default.
• W3213929596 doi "https://doi.org/10.3390/cells10113116" @default.
• W3213929596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8618022" @default.
• W3213929596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34831335" @default.
• W3213929596 hasPublicationYear "2021" @default.
• W3213929596 type Work @default.
• W3213929596 sameAs 3213929596 @default.
• W3213929596 citedByCount "9" @default.
• W3213929596 countsByYear W32139295962022 @default.
• W3213929596 countsByYear W32139295962023 @default.
• W3213929596 crossrefType "journal-article" @default.
• W3213929596 hasAuthorship W3213929596A5003586612 @default.
• W3213929596 hasAuthorship W3213929596A5015280776 @default.
• W3213929596 hasAuthorship W3213929596A5044375884 @default.
• W3213929596 hasAuthorship W3213929596A5053256015 @default.
• W3213929596 hasAuthorship W3213929596A5066234732 @default.
• W3213929596 hasAuthorship W3213929596A5068366638 @default.
• W3213929596 hasAuthorship W3213929596A5077531224 @default.
• W3213929596 hasAuthorship W3213929596A5089131482 @default.
• W3213929596 hasAuthorship W3213929596A5090491021 @default.
• W3213929596 hasBestOaLocation W32139295961 @default.
• W3213929596 hasConcept C10205521 @default.
• W3213929596 hasConcept C126322002 @default.
• W3213929596 hasConcept C148125776 @default.
• W3213929596 hasConcept C1491633281 @default.
• W3213929596 hasConcept C153911025 @default.
• W3213929596 hasConcept C154317977 @default.
• W3213929596 hasConcept C159912055 @default.

• next