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- W3213961566 abstract "Dynamic contacts between cells within the developing neuroepithelium are poorly understood but play important roles in cell and tissue morphology and cell signalling. Here, using live-cell imaging and electron microscopy we reveal multiple distinct protrusive structures in chicken neuroepithelial apical endfeet, including sub-apical protrusions that extend laterally within the tissue, and observe similar structures in human neuroepithelium. We characterise the dynamics, shape, and cytoskeleton of these lateral protrusions and distinguish these structures from cytonemes/filopodia and tunnelling nanotubes. We demonstrate that lateral protrusions form a latticework of membrane contacts between non-adjacent cells, depend on actin but not microtubule dynamics and provide a lamellipodial-like platform for further extending fine actin-dependent filipodia. We find that lateral protrusions depend on the actin-binding protein WAVE1: mutant-WAVE1 misexpression attenuated protrusion and generated a round-ended apical endfoot morphology. However, this did not alter apico-basal cell polarity nor reduce tissue integrity. During normal neuronal delamination sub-apical protrusions were withdrawn, but mutant-WAVE1-induced precocious protrusion loss was insufficient to trigger neurogenesis. This study uncovers a new form of cell-cell contact within the developing neuroepithelium regulation of which prefigures neuronal delamination." @default.
- W3213961566 created "2021-11-22" @default.
- W3213961566 creator A5000988484 @default.
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- W3213961566 date "2021-11-04" @default.
- W3213961566 modified "2023-10-18" @default.
- W3213961566 title "A lateral protrusion latticework connects neuroepithelial cells and is regulated during neurogenesis" @default.
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- W3213961566 doi "https://doi.org/10.1101/2021.11.04.467255" @default.
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