FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214014783> ?p ?o ?g. }

• W3214014783 endingPage "10782" @default.
• W3214014783 startingPage "10782" @default.
• W3214014783 abstract "For cells and tissues, cell–cell and cell–extracellular matrix adhesion is important for proliferation, differentiation, and response to mechanical stimuli. This adhesion is provided by various cell adhesion molecules (CAMs). However, in breast cancer, depending upon the type and stage, this adherence is dysregulated where the expression of these cell adhesion molecules is either overregulated or unregulated, triggering essential oncogenic pathways. Thus, to control the invasiveness of tumor cells, and reduce metastasis, regulating the homophilic and heterophilic interaction of these molecules and controlling the essential cell pathways is important. In this study, we targeted critical CAMs- integrins to regulate their aberrated behavior via siRNAs delivery. However, as due to charge repulsion and propensity to be degraded by nucleases prior to reaching the target site, naked siRNAs are unable to cross plasma membrane, use of a suitable carrier vehicle is essential. Thus, we employed carbonate apatite (CA), to deliver the selected siRNAs targeting integrin αv, α6, β1, β3, β4, β5, and β6 subunits to various breast cancer cell lines and 4T1-breast cancer induced murine model. Delivery of individual integrin siRNAs complexed with CA nanoparticles (NPs) reduced cell viability and caused decrease in tumor burden. To check the gene knockdown effects on phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) and extracellular signal–regulated kinases/mitogen-activated protein kinase (ERK/MAPK) pathways, Western blot analysis was performed, revealing downregulation of the signaling molecules. Thus, CA-facilitated gene therapy targeting various integrins could poise potential therapeutic modality against breast cancer." @default.
• W3214014783 created "2021-11-22" @default.
• W3214014783 creator A5040641974 @default.
• W3214014783 creator A5090107841 @default.
• W3214014783 date "2021-11-15" @default.
• W3214014783 modified "2023-09-26" @default.
• W3214014783 title "Nanoparticles-Facilitated Intracellular Transport of siRNAs against Individual Integrin Subunits Inhibits Growth of Breast Cancer Cells" @default.
• W3214014783 cites W142805830 @default.
• W3214014783 cites W1494085200 @default.
• W3214014783 cites W1548499384 @default.
• W3214014783 cites W1587875952 @default.
• W3214014783 cites W1835561921 @default.
• W3214014783 cites W1908125378 @default.
• W3214014783 cites W1969550859 @default.
• W3214014783 cites W1974777081 @default.
• W3214014783 cites W1979522770 @default.
• W3214014783 cites W1979988883 @default.
• W3214014783 cites W1982473933 @default.
• W3214014783 cites W1983628734 @default.
• W3214014783 cites W2001349369 @default.
• W3214014783 cites W2002219680 @default.
• W3214014783 cites W2004666525 @default.
• W3214014783 cites W2011438251 @default.
• W3214014783 cites W2022520845 @default.
• W3214014783 cites W2026435290 @default.
• W3214014783 cites W2029696463 @default.
• W3214014783 cites W2034278840 @default.
• W3214014783 cites W2035538867 @default.
• W3214014783 cites W2043757927 @default.
• W3214014783 cites W2047302166 @default.
• W3214014783 cites W2050400041 @default.
• W3214014783 cites W2076679216 @default.
• W3214014783 cites W2079323372 @default.
• W3214014783 cites W2083466846 @default.
• W3214014783 cites W2084243350 @default.
• W3214014783 cites W2101225190 @default.
• W3214014783 cites W2108713158 @default.
• W3214014783 cites W2108861663 @default.
• W3214014783 cites W2124728103 @default.
• W3214014783 cites W2127905380 @default.
• W3214014783 cites W2128178837 @default.
• W3214014783 cites W2134212894 @default.
• W3214014783 cites W2138164563 @default.
• W3214014783 cites W2147000598 @default.
• W3214014783 cites W2148885171 @default.
• W3214014783 cites W2149076446 @default.
• W3214014783 cites W2152776641 @default.
• W3214014783 cites W2159184270 @default.
• W3214014783 cites W2160352413 @default.
• W3214014783 cites W2161397941 @default.
• W3214014783 cites W2175953601 @default.
• W3214014783 cites W2201926879 @default.
• W3214014783 cites W2231721598 @default.
• W3214014783 cites W2235060896 @default.
• W3214014783 cites W2254930408 @default.
• W3214014783 cites W2328235677 @default.
• W3214014783 cites W2398347307 @default.
• W3214014783 cites W2408464094 @default.
• W3214014783 cites W2417740873 @default.
• W3214014783 cites W2519598273 @default.
• W3214014783 cites W2530131374 @default.
• W3214014783 cites W2593940162 @default.
• W3214014783 cites W2594683399 @default.
• W3214014783 cites W2621472325 @default.
• W3214014783 cites W308364951 @default.
• W3214014783 cites W185134482 @default.
• W3214014783 doi "https://doi.org/10.3390/app112210782" @default.
• W3214014783 hasPublicationYear "2021" @default.
• W3214014783 type Work @default.
• W3214014783 sameAs 3214014783 @default.
• W3214014783 citedByCount "0" @default.
• W3214014783 crossrefType "journal-article" @default.
• W3214014783 hasAuthorship W3214014783A5040641974 @default.
• W3214014783 hasAuthorship W3214014783A5090107841 @default.
• W3214014783 hasBestOaLocation W32140147831 @default.
• W3214014783 hasConcept C121608353 @default.
• W3214014783 hasConcept C1491633281 @default.
• W3214014783 hasConcept C16224149 @default.
• W3214014783 hasConcept C184235292 @default.
• W3214014783 hasConcept C185592680 @default.
• W3214014783 hasConcept C195687474 @default.
• W3214014783 hasConcept C22615655 @default.
• W3214014783 hasConcept C502942594 @default.
• W3214014783 hasConcept C54009773 @default.
• W3214014783 hasConcept C54355233 @default.
• W3214014783 hasConcept C55493867 @default.
• W3214014783 hasConcept C57074206 @default.
• W3214014783 hasConcept C62478195 @default.
• W3214014783 hasConcept C75217442 @default.
• W3214014783 hasConcept C81885089 @default.
• W3214014783 hasConcept C85789140 @default.
• W3214014783 hasConcept C86554907 @default.
• W3214014783 hasConcept C86803240 @default.
• W3214014783 hasConcept C95444343 @default.
• W3214014783 hasConcept C96232424 @default.
• W3214014783 hasConceptScore W3214014783C121608353 @default.
• W3214014783 hasConceptScore W3214014783C1491633281 @default.
• W3214014783 hasConceptScore W3214014783C16224149 @default.

• next