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- W3214014837 abstract "Clonidine is an antihypertensive medication, that has analgesic and sedative effects. Several properties associated with this agent favored the expansion of its use during the anesthesia and perioperative period. However, the unique pharmacodynamic profile demands care in clinical handling to achieve the desired therapy. Furthermore, the therapeutic effect is maximum within a narrow range of plasma concentration. This requires that clonidine therapy be individualized and carefully monitored, to avoid and correct possible failures and possible adverse effects. The purpose of this chapter was to describe the pharmacological characteristics and clinical applications of clonidine in the perioperative period, aiming to guide its best use, based on scientific evidences." @default.
- W3214014837 created "2021-11-22" @default.
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- W3214014837 date "2022-01-01" @default.
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- W3214014837 title "Clonidine: Features and applications" @default.
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- W3214014837 doi "https://doi.org/10.1016/b978-0-12-820237-1.00009-0" @default.
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